6380. Teclistamab, a B-cell maturation antigen × CD3 bispecific antibody, in patients with relapsed or refractory multiple myeloma (MajesTEC-1): a multicentre, open-label, single-arm, phase 1 study.
作者: Saad Z Usmani.;Alfred L Garfall.;Niels W C J van de Donk.;Hareth Nahi.;Jesus F San-Miguel.;Albert Oriol.;Laura Rosinol.;Ajai Chari.;Manisha Bhutani.;Lionel Karlin.;Lotfi Benboubker.;Lixia Pei.;Raluca Verona.;Suzette Girgis.;Tara Stephenson.;Yusri Elsayed.;Jeffrey Infante.;Jenna D Goldberg.;Arnob Banerjee.;María-Victoria Mateos.;Amrita Krishnan.
来源: Lancet. 2021年398卷10301期665-674页
There is a need for novel therapies for relapsed or refractory multiple myeloma, and B-cell maturation antigen (BCMA) is a validated target. Teclistamab is a bispecific antibody that binds BCMA and CD3 to redirect T cells to multiple myeloma cells. The aim of the MajesTEC-1 study was to evaluate the safety, tolerability, and preliminary efficacy of teclistamab in patients with relapsed or refractory multiple myeloma.
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