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6241. Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.
作者: Yong Chen.;Zi-Long Wang.;Michele Yeo.;Qiao-Juan Zhang.;Ana E López-Romero.;Hui-Ping Ding.;Xin Zhang.;Qian Zeng.;Sara L Morales-Lázaro.;Carlene Moore.;Ying-Ai Jin.;Huang-He Yang.;Johannes Morstein.;Andrey Bortsov.;Marcin Krawczyk.;Frank Lammert.;Manal Abdelmalek.;Anna Mae Diehl.;Piotr Milkiewicz.;Andreas E Kremer.;Jennifer Y Zhang.;Andrea Nackley.;Tony E Reeves.;Mei-Chuan Ko.;Ru-Rong Ji.;Tamara Rosenbaum.;Wolfgang Liedtke.
来源: Gastroenterology. 2021年161卷1期301-317.e16页
Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus.
6242. A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer.
作者: Yuma Wada.;Mitsuo Shimada.;Tatsuro Murano.;Hiroyuki Takamaru.;Yuji Morine.;Tetsuya Ikemoto.;Yu Saito.;Francesc Balaguer.;Luis Bujanda.;Maria Pellise.;Ken Kato.;Yutaka Saito.;Hiroaki Ikematsu.;Ajay Goel.
来源: Gastroenterology. 2021年161卷1期151-162.e1页
We recently reported use of tissue-based transcriptomic biomarkers (microRNA [miRNA] or messenger RNA [mRNA]) for identification of lymph node metastasis (LNM) in patients with invasive submucosal colorectal cancers (T1 CRC). In this study, we translated our tissue-based biomarkers into a blood-based liquid biopsy assay for noninvasive detection of LNM in patients with high-risk T1 CRC.
6243. Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
作者: Pengfei Xu.;Yue Xi.;Junjie Zhu.;Min Zhang.;Zigmund Luka.;Donna B Stolz.;Xinran Cai.;Yang Xie.;Meishu Xu.;Songrong Ren.;Zhiying Huang.;Da Yang.;John D York.;Xiaochao Ma.;Wen Xie.
来源: Gastroenterology. 2021年161卷1期271-286.e11页
Sulfation is a conjugation reaction essential for numerous biochemical and cellular functions in mammals. The 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the key enzyme to generate PAPS, which is the universal sulfonate donor for all sulfation reactions. The goal of this study was to determine whether and how PAPSS2 plays a role in colitis and colonic carcinogenesis.
6244. Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
作者: Jiaoyu Ai.;Sonja M Wörmann.;Kıvanç Görgülü.;Mireia Vallespinos.;Sladjana Zagorac.;Sonia Alcala.;Nan Wu.;Derya Kabacaoglu.;Alexandra Berninger.;Diego Navarro.;Ezgi Kaya-Aksoy.;Dietrich A Ruess.;Katrin J Ciecielski.;Marlena Kowalska.;Ihsan Ekin Demir.;Güralp O Ceyhan.;Irina Heid.;Rickmer Braren.;Marc Riemann.;Sabrina Schreiner.;Samuel Hofmann.;Maria Kutschke.;Martin Jastroch.;Julia Slotta-Huspenina.;Alexander Muckenhuber.;Anna Melissa Schlitter.;Roland M Schmid.;Katja Steiger.;Kalliope N Diakopoulos.;Marina Lesina.;Bruno Sainz.;Hana Algül.
来源: Gastroenterology. 2021年161卷1期318-332.e9页
The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms and personalized therapy. The contribution of mechanisms regulating the cancer stem cell (CSC) population in different subtypes remains unknown.
6252. Elevated Liver Enzymes, Ferritin, C-reactive Protein, D-dimer, and Age Are Predictive Markers of Outcomes Among African American and Hispanic Patients With Coronavirus Disease 2019.
作者: Hassan Ashktorab.;Antonio Pizuorno.;Farshad Aduli.;Adeyinka O Laiyemo.;Gholamreza Oskrochi.;Hassan Brim.
来源: Gastroenterology. 2021年161卷1期345-349页 6257. Outcomes of Thermal Ablation of the Mucosal Defect Margin After Endoscopic Mucosal Resection: A Prospective, International, Multicenter Trial of 1000 Large Nonpedunculated Colorectal Polyps.
作者: Mayenaaz Sidhu.;Neal Shahidi.;Sunil Gupta.;Lobke Desomer.;Sergei Vosko.;W Arnout van Hattem.;Luke F Hourigan.;Eric Y T Lee.;Alan Moss.;Spiro Raftopoulos.;Steven J Heitman.;Stephen J Williams.;Simon Zanati.;David J Tate.;Nicholas Burgess.;Michael J Bourke.
来源: Gastroenterology. 2021年161卷1期163-170.e3页
Thermal ablation of the defect margin after endoscopic mucosal resection (EMR-T) for treating large (≥20 mm) nonpedunculated colorectal polyps (LNPCPs) has shown efficacy in a randomized trial, with a 4-fold reduction, in residual or recurrent adenoma (RRA) at first surveillance colonoscopy (SC1). The clinical effectiveness of this treatment, in the real world, remains unknown.
6259. Targeting the Myeloid-Derived Suppressor Cell Compartment for Inducing Responsiveness to Immune Checkpoint Blockade Is Best Limited to Specific Subtypes of Gastric Cancers.6260. Gastrointestinal symptoms as the first manifestation of antiphospholipid syndrome.
作者: Xiaojuan Zou.;Zhongqi Fan.;Ling Zhao.;Weiling Xu.;Jin Zhang.;Zhenyu Jiang.
来源: BMC Gastroenterol. 2021年21卷1期148页
Antiphospholipid syndrome (APS) is an acquired pre-thrombotic autoimmune condition, which produces autoantibodies called antiphospholipid antibodies (APL) against phospholipid-binding plasma proteins. The diagnosis of APS requires at least one of Sapporo standard clinical manifestations and one laboratory criteria (persistently medium/high titer anticardiolipin antibodies, and/or medium/high titer anti-β2-glycoprotein I antibodies, and/or a positive lupus anticoagulant test). Gastrointestinal lesions are rarely reported in APS patients. APS cases with recurrent abdominal pain as the first clinical manifestation are even rarer.
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