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6141. Hospitalization and surgery rates in patients with inflammatory bowel disease in Brazil: a time-trend analysis.
作者: Flávia Gonçalves Musauer Palacio.;Lucila Marieta Perrotta de Souza.;Jéssica Pronestino de Lima Moreira.;Ronir Raggio Luiz.;Heitor Siffert Pereira de Souza.;Cyrla Zaltman.
来源: BMC Gastroenterol. 2021年21卷1期192页
The prevalence of inflammatory bowel disease (IBD) is increasing globally, and the disease is frequently managed surgically. The aim of this study was to investigate the time trends and geographic distribution of IBD hospitalizations, surgeries and surgical-associated lethality.
6142. Nomogram for predicting advanced liver fibrosis and cirrhosis in patients with chronic liver disease.
作者: Rongrong Ding.;Xinlan Zhou.;Dan Huang.;Yanbing Wang.;Xiufen Li.;Li Yan.;Wei Lu.;Zongguo Yang.;Zhanqing Zhang.
来源: BMC Gastroenterol. 2021年21卷1期190页
We aimed to formulate a novel predictive nomogram to discriminate liver fibrosis stage in patients with chronic liver disease.
6143. Infliximab-induced seizures in a patient with Crohn's disease: a case report.
Infliximab-induced seizures in patients with Crohn's disease are extremely rare and the mechanism of infliximab-induced seizures is unclear.
6146. MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment.
作者: Ying Lu.;Yangyang Li.;Qi Liu.;Na Tian.;Peng Du.;Fangming Zhu.;Yichao Han.;Xinnan Liu.;Xisheng Liu.;Xiao Peng.;Xiaoxia Wang.;Yuchen Wu.;Lingfeng Tong.;Yakui Li.;Yemin Zhu.;Lifang Wu.;Ping Zhang.;Ye Xu.;Hanbei Chen.;Bin Li.;Xuemei Tong.
来源: Gastroenterology. 2021年161卷2期575-591.e16页
The metabolic features and function of intratumoral regulatory T cells (Tregs) are ambiguous in colorectal cancer. Tumor-infiltrating Tregs are reprogrammed to exhibit high glucose-depleting properties and adapt to the glucose-restricted microenvironment. The glucose-responsive transcription factor MondoA is highly expressed in Tregs. However, the role of MondoA in colorectal cancer-infiltrating Tregs in response to glucose limitation remains to be elucidated.
6148. Colonic Motility Is Improved by the Activation of 5-HT2B Receptors on Interstitial Cells of Cajal in Diabetic Mice.
作者: Byungchang Jin.;Se Eun Ha.;Lai Wei.;Rajan Singh.;Hannah Zogg.;Brooke Clemmensen.;Dante J Heredia.;Thomas W Gould.;Kenton M Sanders.;Seungil Ro.
来源: Gastroenterology. 2021年161卷2期608-622.e7页
Constipation is commonly associated with diabetes. Serotonin (5-HT), produced predominantly by enterochromaffin (EC) cells via tryptophan hydroxylase 1 (TPH1), is a key modulator of gastrointestinal (GI) motility. However, the role of serotonergic signaling in constipation associated with diabetes is unknown.
6149. Nonfood Prebiotic, Probiotic, and Synbiotic Use Has Increased in US Adults and Children From 1999 to 2018.
作者: Lauren E O'Connor.;Jaime J Gahche.;Kirsten A Herrick.;Cindy D Davis.;Nancy Potischman.;Ashley J Vargas.
来源: Gastroenterology. 2021年161卷2期476-486.e3页
Public interest in pre-, pro-, and synbiotic products is increasing because of interactions between gut microbiota and human health. Our aim was to describe nonfood (from dietary supplements or medication) pre-, pro-, and synbiotic use by US adults and children and reported reasons.
6150. Tumor-Secreted Extracellular Vesicles Regulate T-Cell Costimulation and Can Be Manipulated To Induce Tumor-Specific T-Cell Responses.
作者: Xianda Zhao.;Ce Yuan.;Dechen Wangmo.;Subbaya Subramanian.
来源: Gastroenterology. 2021年161卷2期560-574.e11页
Colorectal cancer is a major cause of cancer-related deaths worldwide. Immune checkpoint blockade therapies are effective in 30%-60% of the microsatellite instable-high subtype. Unfortunately, most patients with colorectal cancer (>85%) have microsatellite stable tumors that do not respond. In this study, we aimed to decipher the underlying tumor-intrinsic mechanisms critical for improving immunotherapy in colorectal cancer.
6151. Blood-Based Liquid Biopsies: A Noninvasive and Cost-Effective Tool for Improved Risk Assessment and Identification of Lymph Node Metastasis in Patients With Submucosal T1 Colorectal Cancer.6152. A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
作者: Cora Olpe.;Doran Khamis.;Maria Chukanova.;Nefeli Skoufou-Papoutsaki.;Richard Kemp.;Kate Marks.;Cerys Tatton.;Cecilia Lindskog.;Anna Nicholson.;Roxanne Brunton-Sim.;Shalini Malhotra.;Rogier Ten Hoopen.;Rachael Stanley.;Douglas J Winton.;Edward Morrissey.
来源: Gastroenterology. 2021年161卷2期548-559.e23页
Colorectal cancer (CRC) is thought to arise when the cumulative mutational burden within colonic crypts exceeds a certain threshold that leads to clonal expansion and ultimately neoplastic transformation. Therefore, quantification of the fixation and subsequent expansion of somatic mutations in normal epithelium is key to understanding colorectal cancer initiation. The aim of the present study was to determine how advantaged expansions can be accommodated in the human colon.
6153. Mortality rates and risk factors in 1412 Japanese patients with decompensated hepatitis C virus-related cirrhosis: a retrospective long-term cohort study.
作者: Shunichiro Fujiyama.;Norio Akuta.;Hitomi Sezaki.;Mariko Kobayashi.;Yusuke Kawamura.;Tetsuya Hosaka.;Masahiro Kobayashi.;Satoshi Saitoh.;Fumitaka Suzuki.;Yoshiyuki Suzuki.;Yasuji Arase.;Kenji Ikeda.;Hiromitsu Kumada.
来源: BMC Gastroenterol. 2021年21卷1期189页
Hepatitis C virus is the leading cause of liver cirrhosis and hepatocellular carcinoma in Japan. We aimed to examine the long-term (> 20 years) mortality and hepatocellular carcinoma rates and associated risk factors in 1412 Japanese patients with decompensated hepatitis C virus-related cirrhosis (Child-Pugh B or C).
6154. Circulating miRNA-202-3p is a potential novel biomarker for diagnosis of type 1 gastric neuroendocrine neoplasms.
作者: Dou Dou.;Xiao-Kou Li.;Qi-Sheng Xia.;Ying-Ying Chen.;Yuan-Liang Li.;Chao Wang.;Zhi-Rong Qi.;Huang-Ying Tan.
来源: BMC Gastroenterol. 2021年21卷1期188页
Currently, there are no circulating diagnostic biomarkers for gastric neuroendocrine neoplasms (g-NENs). In previous studies, we found that miRNA-202-3p is overexpressed in the tumour tissue of type 1 g-NEN. We speculated that miRNA-202-3p is also likely to be highly expressed in circulating blood.
6157. Acute surgical-like abdomen as a gastrointestinal manifestation of COVID-19 infection: a case report in Colombia.
作者: Fernando Sierra-Arango.;Cathalina Vergara-Cabra.;Mariana Vásquez-Roldan.;Erika D Pérez-Riveros.
来源: BMC Gastroenterol. 2021年21卷1期187页
The SARS-CoV-2 pandemic is a considerable public health problem, which has caused a burden on health systems in many countries. Despite the existence of multiple studies on the different digestive symptoms and their relationship with this disease, it is still vital to highlight the severity of the different symptoms, the need to diagnose it properly and quickly. Currently in Colombia there are no writings that highlight the above.
6160. Serologic Response to Messenger RNA Coronavirus Disease 2019 Vaccines in Inflammatory Bowel Disease Patients Receiving Biologic Therapies.
作者: Serre-Yu Wong.;Rebekah Dixon.;Vicky Martinez Pazos.;Sacha Gnjatic.;Jean-Frederic Colombel.;Ken Cadwell.; .
来源: Gastroenterology. 2021年161卷2期715-718.e4页 |