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5922. Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus.
作者: Keli Yang.;Junkun Niu.;Tao Zuo.;Yang Sun.;Zhilu Xu.;Whitney Tang.;Qin Liu.;Jingwan Zhang.;Enders K W Ng.;Simon K H Wong.;Yun Kit Yeoh.;Paul K S Chan.;Francis K L Chan.;Yinglei Miao.;Siew C Ng.
来源: Gastroenterology. 2021年161卷4期1257-1269.e13页
Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM.
5929. Biliary peritonitis due to liver cyst rupture in autosomal dominant polycystic kidney disease.
作者: Hiroshi Matsuo.;Kan Katayama.;Aoi Hayasaki.;Yusuke Iizawa.;Mayumi Endo.;Tomohiro Murata.;Shugo Mizuno.;Kaoru Dohi.
来源: BMC Gastroenterol. 2021年21卷1期267页
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic kidney disease and polycystic liver disease is its major extrarenal manifestation, however biliary peritonitis due to a liver cyst rupture is extremely rare.
5930. MiR-342 inhibits proliferation and apoptosis of liver cancer cells via targeting LGR5 and via regulating Wnt/β-catenin signaling pathway.
作者: Yunquan Guo.;Huan Zhang.;Cuicui Wang.;Wenli Ji.;Yanzhen Cao.
来源: Minerva Gastroenterol (Torino). 2022年68卷2期238-239页 5931. Therapy in elderly IBD patients.
作者: Fabiana Castiglione.;Nicola Imperatore.;Fabiana Zingone.;Renata D'Incà.
来源: Minerva Gastroenterol (Torino). 2024年70卷1期89-97页
Appropriate treatment is critical in elderly inflammatory bowel disease (IBD) subjects since they are at higher risk of complications such as infections, malignancies and mortality.
5932. Esophageal Hypervigilance and Symptom-Specific Anxiety in Patients with Eosinophilic Esophagitis.
作者: Tiffany H Taft.;Dustin A Carlson.;Madison Simons.;Sonia Zavala.;Ikuo Hirano.;Nirmala Gonsalves.;John E Pandolfino.
来源: Gastroenterology. 2021年161卷4期1133-1144页
Patient symptom reporting often does not correlate with the pathophysiological markers of esophageal disease, including eosinophilic esophagitis (EoE). Esophageal hypervigilance and symptom-specific anxiety are emerging as important considerations in understanding symptom reporting. As such, we aimed to conduct the first study of these constructs in EoE.
5935. Interferon-Gamma-Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor-Colitis.
作者: Sarah C Sasson.;Stephanie M Slevin.;Vincent T F Cheung.;Isar Nassiri.;Anna Olsson-Brown.;Eve Fryer.;Ricardo C Ferreira.;Dominik Trzupek.;Tarun Gupta.;Lulia Al-Hillawi.;Mari-Lenna Issaias.;Alistair Easton.;Leticia Campo.;Michael E B FitzPatrick.;Joss Adams.;Meenali Chitnis.;Andrew Protheroe.;Mark Tuthill.;Nicholas Coupe.;Alison Simmons.;Miranda Payne.;Mark R Middleton.;Simon P L Travis.; .;Benjamin P Fairfax.;Paul Klenerman.;Oliver Brain.
来源: Gastroenterology. 2021年161卷4期1229-1244.e9页
The pathogenesis of immune checkpoint inhibitor (ICI)-colitis remains incompletely understood. We sought to identify key cellular drivers of ICI-colitis and their similarities to idiopathic ulcerative colitis, and to determine potential novel therapeutic targets.
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