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5902. Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
作者: Michele Bortolomeazzi.;Mohamed Reda Keddar.;Lucia Montorsi.;Amelia Acha-Sagredo.;Lorena Benedetti.;Damjan Temelkovski.;Subin Choi.;Nedyalko Petrov.;Katrina Todd.;Patty Wai.;Johannes Kohl.;Tamara Denner.;Emma Nye.;Robert Goldstone.;Sophia Ward.;Gareth A Wilson.;Maise Al Bakir.;Charles Swanton.;Susan John.;James Miles.;Banafshe Larijani.;Victoria Kunene.;Elisa Fontana.;Hendrik-Tobias Arkenau.;Peter J Parker.;Manuel Rodriguez-Justo.;Kai-Keen Shiu.;Jo Spencer.;Francesca D Ciccarelli.
来源: Gastroenterology. 2021年161卷4期1179-1193页
Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer tissue and associated tumor microenvironment (TME) from patients treated with pembrolizumab (KEYNOTE 177 clinical trial) or nivolumab to dissect the cellular and molecular determinants of response to anti- programmed cell death 1 (PD1) immunotherapy.
5906. Increased Vδ1γδT cells predominantly contributed to IL-17 production in the development of adult human post-infectious irritable bowel syndrome.
作者: L W Dong.;X N Sun.;Z C Ma.;J Fu.;F J Liu.;B L Huang.;D C Liang.;D M Sun.;Cheng Lan.
来源: BMC Gastroenterol. 2021年21卷1期271页
γδT cells play an important role in the mucosa inflammation and immunity-associated disorders. Our previous study reported that γδ T cells producing IL-17 were involved in the pathogenesis of post-infectious irritable bowel syndrome (PI-IBS). However, their subset characteristic profile in this kind of disease remains unclear. Thus the current study's aim is to investigate the functionally predominant subset and its role in PI-IBS.
5907. Tumor-to-tumor metastasis of diffuse large B cell lymphoma to gastric adenocarcinoma via CXCL12 (SDF-1)/CXCR4 axis: a case report.
作者: Yusuke Kamihara.;Sayaka Murai.;Shohei Kikuchi.;Akinori Wada.;Jun Murakami.;Nam H Dang.;Tsutomu Sato.
来源: BMC Gastroenterol. 2021年21卷1期270页
Tumor-to-tumor metastasis is the rare phenomenon in which one tumor exhibits metastatic deposits from another. To the best of our knowledge, there has been no prior reported case of tumor-to-tumor metastasis of a diffuse large B cell lymphoma (DLBCL) to a primary gastric adenocarcinoma.
5908. The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study.
作者: Kalliopi Foteinogiannopoulou.;Konstantinos Karmiris.;Georgios Axiaris.;Magdalini Velegraki.;Antonios Gklavas.;Christina Kapizioni.;Charalabos Karageorgos.;Christina Kateri.;Anastasia Katsoula.;Georgios Kokkotis.;Evgenia Koureta.;Charikleia Lamouri.;Panagiotis Markopoulos.;Maria Palatianou.;Ploutarchos Pastras.;Konstantinos Fasoulas.;Olga Giouleme.;Evanthia Zampeli.;Aggeliki Theodoropoulou.;Georgios Theocharis.;Konstantinos Thomopoulos.;Pantelis Karatzas.;Konstantinos H Katsanos.;Andreas Kapsoritakis.;Anastasia Kourikou.;Nikoleta Mathou.;Spilios Manolakopoulos.;Georgios Michalopoulos.;Spyridon Michopoulos.;Alexandros Boubonaris.;Giorgos Bamias.;Vasileios Papadopoulos.;George Papatheodoridis.;Ioannis Papaconstantinou.;Ioannis Pachiadakis.;Konstantinos Soufleris.;Maria Tzouvala.;Christos Triantos.;Eftychia Tsironi.;Dimitrios K Christodoulou.;Ioannis E Koutroubakis.; .
来源: BMC Gastroenterol. 2021年21卷1期269页
Anemia is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD) affecting negatively the patients' quality of life. The aim of this study was to determine the frequency and real-life management of anemia in IBD patients in Greece.
5912. Rare Hypomorphic Sucrase Isomaltase Variants in Relation to Irritable Bowel Syndrome Risk in UK Biobank.
作者: Tenghao Zheng.;Leticia Camargo-Tavares.;Ferdinando Bonfiglio.;Francine Z Marques.;Hassan Y Naim.;Mauro D'Amato.
来源: Gastroenterology. 2021年161卷5期1712-1714页 5914. The Enhanced Liver Fibrosis test maintains its diagnostic and prognostic performance in alcohol-related liver disease: a cohort study.
作者: Declan Connoley.;Preya Janubhai Patel.;Brian Hogan.;Sudeep Tanwar.;Freya Rhodes.;Julie Parkes.;Alastair Burt.;Jennifer Watkins.;William Sievert.;William Rosenberg.
来源: BMC Gastroenterol. 2021年21卷1期268页
Alcohol is the main cause of chronic liver disease. The Enhanced Liver Fibrosis (ELF) test is a serological biomarker for fibrosis staging in chronic liver disease, however its utility in alcohol-related liver disease warrants further validation. We assessed the diagnostic and prognostic performance of ELF in alcohol-related liver disease.
5915. Endoscopic Submucosal Dissection in Europe: Results of 1000 Neoplastic Lesions From the German Endoscopic Submucosal Dissection Registry.
作者: Carola Fleischmann.;Andreas Probst.;Alanna Ebigbo.;Siegbert Faiss.;Brigitte Schumacher.;H-P Allgaier.;F L Dumoulin.;Ingo Steinbrueck.;Michael Anzinger.;Joerg Marienhagen.;Anna Muzalyova.;Helmut Messmann.
来源: Gastroenterology. 2021年161卷4期1168-1178页
Endoscopic submucosal dissection (ESD) enables the curative resection of early malignant lesions and is associated with reduced recurrence risk. Due to the lack of comprehensive ESD data in the West, the German ESD registry was set up to evaluate relevant outcomes of ESD.
5917. Prospective Assessment for Prediabetes and New-Onset Diabetes in High-Risk Individuals Undergoing Pancreatic Cancer Screening.
作者: Ishani Shah.;Vaibhav Wadhwa.;Mohammad Bilal.;Katharine A Germansky.;Mandeep S Sawhney.; .
来源: Gastroenterology. 2021年161卷5期1689-1691.e1页 |