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5721. Hereditary hemorrhagic telangiectasia with liver cirrhosis: a case report.
Hereditary hemorrhagic telangiectasia is an autosomal dominant hereditary hemorrhagic disease. Its main feature is an abnormal structure of the blood vessel wall. Cirrhosis of the liver is a common chronic progressive disease with one or more causes in which diffuse liver damage occurs after long-term or repeated injury. Liver cirrhosis can cause dilation of gastrointestinal capillaries. Many patients with hereditary hemorrhagic telangiectasia accompanied by gastrointestinal vascular malformations and liver cirrhosis may be diagnosed only with liver cirrhosis if the clinician does not pay attention to physical examination findings and family history. Moreover, general treatment measures, such as blood transfusion, iron supplementation, and application of hemostatic drugs, are less effective for bleeding in patients with hereditary hemorrhagic telangiectasia than in those with liver cirrhosis alone.
5722. A Multilocus Blood-Based Assay Targeting Circulating Tumor DNA Methylation Enables Early Detection and Early Relapse Prediction of Colorectal Cancer.
作者: Guoxiang Cai.;Mingyan Cai.;Zhiqiang Feng.;Rui Liu.;Li Liang.;Pinghong Zhou.; .;Boqun Zhu.;Shaobo Mo.;Hui Wang.;Xiaoliang Lan.;Sanjun Cai.;Ye Xu.;Renjie Wang.;Weixin Dai.;Lingyu Han.;Wenqiang Xiang.;Beili Wang.;Wei Guo.;Lijing Zhang.;Changjiang Zhou.;Binyang Luo.;Yingfei Li.;Yuqiang Nie.;Chengcheng Ma.;Zhixi Su.
来源: Gastroenterology. 2021年161卷6期2053-2056.e2页 5723. Single-Cell DNA Sequencing Reveals Punctuated and Gradual Clonal Evolution in Hepatocellular Carcinoma.
作者: Lin Guo.;Xianfu Yi.;Lu Chen.;Ti Zhang.;Hua Guo.;Ziye Chen.;Jinghui Cheng.;Qi Cao.;Hengkang Liu.;Chunyu Hou.;Lisha Qi.;Zhiyan Zhu.;Yucun Liu.;Ruirui Kong.;Chong Zhang.;Xiaohua Zhou.;Zemin Zhang.;Tianqiang Song.;Ruidong Xue.;Ning Zhang.
来源: Gastroenterology. 2022年162卷1期238-252页
Copy number alterations (CNAs), elicited by genome instability, are a major source of intratumor heterogeneity. How CNAs evolve in hepatocellular carcinoma (HCC) remains unknown.
5724. MELD 3.0: The Model for End-Stage Liver Disease Updated for the Modern Era.
作者: W Ray Kim.;Ajitha Mannalithara.;Julie K Heimbach.;Patrick S Kamath.;Sumeet K Asrani.;Scott W Biggins.;Nicholas L Wood.;Sommer E Gentry.;Allison J Kwong.
来源: Gastroenterology. 2021年161卷6期1887-1895.e4页
The Model for End-Stage Liver Disease (MELD) has been established as a reliable indicator of short-term survival in patients with end-stage liver disease. The current version (MELDNa), consisting of the international normalized ratio and serum bilirubin, creatinine, and sodium, has been used to determine organ allocation priorities for liver transplantation in the United States. The objective was to optimize MELD further by taking into account additional variables and updating coefficients with contemporary data.
5725. Impact of dietary compositions and patterns on the prevalence of nonalcoholic fatty liver disease in Japanese men: a cross-sectional study.
作者: Chihiro Nakashita.;Lu Xi.;Yasushi Inoue.;Ryota Kabura.;Shota Masuda.;Yuko Yamano.;Takahiko Katoh.
来源: BMC Gastroenterol. 2021年21卷1期342页
This study aimed to examine the impact of dietary compositions and patterns on nonalcoholic fatty liver disease (NAFLD) morbidity in Japanese men.
5726. Elevated tumor expression of Astroprincin (FAM171A1) is an independent marker of poor prognosis in colon cancer.
作者: Tuomas Kaprio.;Alexander M Lindström.;Tiina Rasila.;Olga Saavalainen.;Ines Beilmann-Lehtonen.;Harri Mustonen.;Caj Haglund.;Leif C Andersson.
来源: BMC Gastroenterol. 2021年21卷1期341页
Colon cancer (CC) is one of the most commonly diagnosed malignancies worldwide. Several biomarkers have been suggested for improved prognostic evaluation, but few have been implemented in clinical practice. There is a need for biomarkers that predict the tumor behavior in CC and allow stratification of patients that would benefit from adjuvant therapy. We recently identified and functionally characterized a previously unknown protein that we called ASTROPRINCIN (APCN) due to its abundance in astrocytes. APCN, also annotated as FAM171A1, is found in trophoblasts of early placenta. We demonstrated that high expression levels of APCN in cancer cells induced motility and ability of invasive growth in semisolid medium.
5727. Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension.
作者: Carmen Argmann.;Minami Tokuyama.;Ryan C Ungaro.;Ruiqi Huang.;Ruixue Hou.;Sakteesh Gurunathan.;Roman Kosoy.;Antonio Di'Narzo.;Wenhui Wang.;Bojan Losic.;Haritz Irizar.;Lauren Peters.;Aleksandar Stojmirovic.;Gabrielle Wei.;Phillip H Comella.;Mark Curran.;Carrie Brodmerkel.;Joshua R Friedman.;Ke Hao.;Eric E Schadt.;Jun Zhu.;Judy Cho.;Noam Harpaz.;Marla C Dubinsky.;Bruce E Sands.;Andrew Kasarskis.;Saurabh Mehandru.;Jean-Frederic Colombel.;Mayte Suárez-Fariñas.
来源: Gastroenterology. 2021年161卷6期1953-1968.e15页
Disease extent varies in ulcerative colitis (UC) from proctitis to left-sided colitis to pancolitis and is a major prognostic factor. When the extent of UC is limited there is often a sharp demarcation between macroscopically involved and uninvolved areas and what defines this or subsequent extension is unknown. We characterized the demarcation site molecularly and determined genes associated with subsequent disease extension.
5728. Tri-modal management of primary small cell carcinoma of the pancreas (SCCP): a rare neuroendocrine carcinoma (NEC).
作者: Safa Elzein.;Fei Bao.;Ray Lin.;Gabriel Schnickel.;Andrew M Lowy.;Gregory P Botta.
来源: BMC Gastroenterol. 2021年21卷1期340页
Primary small cell carcinoma of the pancreas (SCCP) is a rare malignant neuroendocrine carcinoma (NEC). Typically, it presents with lymphovascular invasion as well as metastasis at the time of diagnosis which portends a dismal prognosis. Treatment is typically based on therapy used for other aggressive NECs such as small cell lung cancer. Although multimodal surgery, radiation and chemotherapy may improve prognosis, the outcome generally remains poor.
5729. The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.
作者: Wei-Ting Kuo.;Li Zuo.;Matthew A Odenwald.;Shariq Madha.;Gurminder Singh.;Christine B Gurniak.;Clara Abraham.;Jerrold R Turner.
来源: Gastroenterology. 2021年161卷6期1924-1939页
Increased permeability is implicated in the pathogenesis of intestinal disease. In vitro and in vivo studies have linked down-regulation of the scaffolding protein ZO-1, encoded by the TJP1 gene, to increased tight junction permeability. This has not, however, been tested in vivo. Here, we assessed the contributions of ZO-1 to in vivo epithelial barrier function and mucosal homeostasis.
5732. PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis.
作者: William J Sandborn.;Larry C Mattheakis.;Nishit B Modi.;David Pugatch.;Brian Bressler.;Scott Lee.;Raj Bhandari.;Bittoo Kanwar.;Richard Shames.;Geert D'Haens.;Stefan Schreiber.;Silvio Danese.;Brian Feagan.;Rish K Pai.;David Y Liu.;Suneel Gupta.
来源: Gastroenterology. 2021年161卷6期1853-1864.e10页
Oral therapies targeting the integrin α4β7 may offer unique advantages for the treatment of inflammatory bowel disease. We characterized the oral α4β7 antagonist peptide PTG-100 in preclinical models and established safety, pharmacokinetic/pharmacodynamic relationships, and efficacy in a phase 2a trial in patients with ulcerative colitis (UC).
5733. Mutation analysis of the ATP7B gene and genotype-phenotype correlation in Chinese patients with Wilson disease.
作者: Mingming Li.;Jing Ma.;Wenlong Wang.;Xu Yang.;Kaizhong Luo.
来源: BMC Gastroenterol. 2021年21卷1期339页
To discover the novel ATP7B mutations in 103 southern Chinese patients with Wilson disease (WD), and to determine the spectrum and frequency of mutations in the ATP7B gene and genotype-phenotype correlation in a large-scale sample of Chinese WD patients.
5739. Zenker's diverticulum in an 85-year-old Ugandan man.
Zenker's diverticulum (ZD) is an uncommon disorder due to an outpouching of tissue through the Killian triangle that is thought to be caused by dysfunction of the cricopharyngeal muscle.
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