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5661. An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer.
作者: Xiaoyan Liang.;Gina N Duronio.;Yaying Yang.;Pratyusha Bala.;Prajna Hebbar.;Sandor Spisak.;Pranshu Sahgal.;Harshabad Singh.;Yanxi Zhang.;Yingtian Xie.;Paloma Cejas.;Henry W Long.;Adam J Bass.;Nilay S Sethi.
来源: Gastroenterology. 2022年162卷1期209-222页
Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC.
5662. Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis.
作者: Jordan P Iannuzzi.;James A King.;Jessica Hope Leong.;Joshua Quan.;Joseph W Windsor.;Divine Tanyingoh.;Stephanie Coward.;Nauzer Forbes.;Steven J Heitman.;Abdel-Aziz Shaheen.;Mark Swain.;Michael Buie.;Fox E Underwood.;Gilaad G Kaplan.
来源: Gastroenterology. 2022年162卷1期122-134页
Acute pancreatitis is a common disease with significant associated morbidity and mortality. We performed a systematic review and meta-analysis of population-based studies to explore the changing temporal trends of acute pancreatitis incidence globally.
5666. Ongoing Global Impact of the COVID-19 Pandemic on Endoscopy: A Subsequent International Survey of 121 Centers From 35 Countries.
作者: Sachin Srinivasan.;Suneha Sundaram.;Fabian Emura.;Nageshwar Reddy.;Douglas O Faigel.;Alessandro Repici.;Sravanthi Parasa.;Prateek Sharma.
来源: Gastroenterology. 2022年162卷1期328-330.e3页 5668. The PSC scientific community resource: an asset for multi-omics interrogation of primary sclerosing cholangitis.
作者: Ahmad Hassan Ali.;Brian D Juran.;Erik M Schlicht.;Jackie K Bianchi.;Bryan M McCauley.;Elizabeth J Atkinson.;Konstantinos N Lazaridis.
来源: BMC Gastroenterol. 2021年21卷1期353页
Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease that often progresses to end-stage liver disease and/or the development of hepatobiliary neoplasia. Lack of prognostic tools and treatment options for PSC is driven in part by our poor understanding of its pathogenesis, which is thought to be complex, the interaction of genetic variants, environmental influences and biological response throughout the course of disease. The PSC Scientific Community Resource (PSC-SCR) seeks to overcome previous shortcomings by facilitating novel research in PSC with the ultimate goals of individualizing patient care and improving patient outcomes.
5669. A novel pN3 gastric cancer staging system with superior prognostic utility based upon the examination of over 31 lymph nodes: a propensity score-matching analysis.
Individuals with pN3 gastric cancer (GC) account for a large proportion of pN + GC, and exhibit poor survival outcomes. The pN3 stage is defined based upon the number of metastatic lymph nodes (mLNs), but the subclassification of pN3 patients based upon the number of examined LNs (eLNs) is rarely performed.
5674. Severe spruelike enteropathy and collagenous colitis caused by olmesartan.
作者: Shiho Kaneko.;Kana Matsuda.;Yasuko Mizuta.;Shoya Shiratori.;Kazuma Kishi.;Akihisa Nakamura.;Masataka Yagisawa.;Nobuyuki Ehira.;Minoru Uebayashi.;Hiroya Kobayashi.
来源: BMC Gastroenterol. 2021年21卷1期350页
Olmesartan, which is an angiotensin II receptor blocker, reportedly causes spruelike enteropathy, with intestinal villous atrophy as its typical histopathological finding. Interestingly, collagenous and/or lymphocytic gastritis and colitis occur in some patients. We report the case of a 73-year-old Japanese man with a 2-month clinical history of severe diarrhea and weight loss. There were few reports in which spruelike enteropathy and collagenous colitis were both observed and could be followed up.
5675. Physiological and histopathological effects of electroporation pulse on stomach of rats.
作者: Yuchi Zhang.;Xuan Han.;Zhuoqun Li.;Yu Zhang.;Lihong Liang.;Xiaoying Ma.;Haonan Liu.;Yihui Gao.;Qingshan Li.;Xue Chen.;Yi Lv.;Fenggang Ren.
来源: BMC Gastroenterol. 2021年21卷1期351页
Irreversible electroporation (IRE) is an emerging tissue ablation technique with widespread potential, especially for cancer treatment. Although the safety and efficacy of IRE for gastric tissue ablation have been demonstrated, there is a gap of knowledge regarding the effect of electroporation pulse (EP) on the physiology and histopathology of the stomach. This study applied EP to the stomach of healthy rats and investigated the digestive function, serum marker levels, and gastric tissue structure of EP-treated rats.
5676. Rising Early-onset Colorectal Cancer Incidence Is Not an Artifact of Increased Screening Colonoscopy Use in a Large, Diverse Healthcare System.
作者: Jeffrey K Lee.;Sophie A Merchant.;Christopher D Jensen.;Caitlin C Murphy.;Natalia Udaltsova.;Douglas A Corley.
来源: Gastroenterology. 2022年162卷1期325-327.e3页 5679. The GLU-10: a validated ten-point score to identify poorly instructed celiac patients in need of dietary interventions.
作者: Marta Vernero.;Annalisa Schiepatti.;Stiliano Maimaris.;Francesca Lusetti.;Davide Scalvini.;Fabiola Megang.;Maria L Nicolardi.;Gian M Gabrielli.;Elisa Sprio.;Paola Baiardi.;Federico Biagi.
来源: Minerva Gastroenterol (Torino). 2022年68卷1期91-97页
A standard tool to assess patients' knowledge about gluten and the gluten-free diet (GFD) is lacking.
5680. The association between irritable bowel syndrome and ischemic colitis: a systematic review and meta-analysis.
作者: Wasit Wongtrakul.;Nipith Charoenngam.;Patompong Ungprasert.
来源: Minerva Gastroenterol (Torino). 2022年68卷4期470-474页
Studies have suggested an association between ischemic colitis and irritable bowel syndrome (IBS) although the results were inconsistent. This systematic review and meta-analysis were performed to comprehensively examine the association between IBS and ischemic colitis by identifying all available cohort and case-control studies and combining their effect estimates together.
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