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5301. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis.
作者: Jennyfer Wolf.;Sydney Hubbard.;Michael Brauer.;Argaw Ambelu.;Benjamin F Arnold.;Robert Bain.;Valerie Bauza.;Joe Brown.;Bethany A Caruso.;Thomas Clasen.;John M Colford.;Matthew C Freeman.;Bruce Gordon.;Richard B Johnston.;Andrew Mertens.;Annette Prüss-Ustün.;Ian Ross.;Jeffrey Stanaway.;Jeff T Zhao.;Oliver Cumming.;Sophie Boisson.
来源: Lancet. 2022年400卷10345期48-59页
Estimates of the effectiveness of water, sanitation, and hygiene (WASH) interventions that provide high levels of service on childhood diarrhoea are scarce. We aimed to provide up-to-date estimates on the burden of disease attributable to WASH and on the effects of different types of WASH interventions on childhood diarrhoea in low-income and middle-income countries (LMICs).
5303. Immobilisation of torus fractures of the wrist in children (FORCE): a randomised controlled equivalence trial in the UK.
作者: Daniel C Perry.;Juul Achten.;Ruth Knight.;Duncan Appelbe.;Susan J Dutton.;Melina Dritsaki.;James M Mason.;Damian T Roland.;Shrouk Messahel.;James Widnall.;Matthew L Costa.; .
来源: Lancet. 2022年400卷10345期39-47页
The most common fractures in children are torus (buckle) fractures of the wrist. Controversy exists over treatment, which ranges from splint immobilisation and discharge to cast immobilisation, follow-up, and repeat imaging. This study compared pain and function in affected children offered a soft bandage and immediate discharge with those receiving rigid immobilisation and follow-up as per treating centre protocol.
5316. Istanbul Protocol 2022 empowers health professionals to end torture.
作者: Vincent Iacopino.;Rohini J Haar.;Michele Heisler.;James Lin.;Şebnem Korur Fincancı.;Chris Esdaile.;Jens Modvig.;Nora Sveaass.;Vivienne H Nathanson.;Nils Melzer.;Juliet Cohen.
来源: Lancet. 2022年400卷10347期143-145页 5318. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial.
作者: Bijoy K Menon.;Brian H Buck.;Nishita Singh.;Yan Deschaintre.;Mohammed A Almekhlafi.;Shelagh B Coutts.;Sibi Thirunavukkarasu.;Houman Khosravani.;Ramana Appireddy.;Francois Moreau.;Gord Gubitz.;Aleksander Tkach.;Luciana Catanese.;Dar Dowlatshahi.;George Medvedev.;Jennifer Mandzia.;Aleksandra Pikula.;Jai Shankar.;Heather Williams.;Thalia S Field.;Alejandro Manosalva.;Muzaffar Siddiqui.;Atif Zafar.;Oje Imoukhuede.;Gary Hunter.;Andrew M Demchuk.;Sachin Mishra.;Laura C Gioia.;Shirin Jalini.;Caroline Cayer.;Stephen Phillips.;Elsadig Elamin.;Ashkan Shoamanesh.;Suresh Subramaniam.;Mahesh Kate.;Gregory Jacquin.;Marie-Christine Camden.;Faysal Benali.;Ibrahim Alhabli.;Fouzi Bala.;MacKenzie Horn.;Grant Stotts.;Michael D Hill.;David J Gladstone.;Alexandre Poppe.;Arshia Sehgal.;Qiao Zhang.;Brendan Cord Lethebe.;Craig Doram.;Ayoola Ademola.;Michel Shamy.;Carol Kenney.;Tolulope T Sajobi.;Richard H Swartz.; .
来源: Lancet. 2022年400卷10347期161-169页
Intravenous thrombolysis with alteplase bolus followed by infusion is a global standard of care for patients with acute ischaemic stroke. We aimed to determine whether tenecteplase given as a single bolus might increase reperfusion compared with this standard of care.
5319. The political and social contexts of global road safety: challenges for the next decade.
The goal of this Series paper is to show how road safety has evolved as a global public health issue over the past two decades and to discuss the political and economic dynamics that led to this change. Specifically, the key stakeholders, influences, networks, issue framing, actor power, and synergistic interactions that have contributed to how road safety has evolved as a global public health issue will be discussed. In doing so, we capture the important chronology of events and discuss a set of challenges that highlight the complexity of road safety. We posit that the global road safety community needs to re-evaluate its role and strategy for the next decade and focus more on implementation and country action to achieve reductions in road traffic injuries. We call for an open and inclusive process to ensure that such a reflection occurs before the end of the current decade.
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