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481. The Journey of Resistant Hypertension: From the Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure to American Heart Association/American College of Cardiology Guidelines.482. Letter by Dai et al Regarding Article, "Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction".483. Patent Foramen Ovale Closure in Patients With and Without Nickel Hypersensitivity: A Randomized Trial.
作者: Anastasios Apostolos.;Stamatios Gregoriou.;Maria Drakopoulou.;Georgios Trantalis.;Aikaterini Tsiogka.;Nikolaos Ktenopoulos.;Konstantina Aggeli.;Alexander Stratigos.;Konstantinos Tsioufis.;Konstantinos Toutouzas.
来源: Circ Cardiovasc Interv. 2025年18卷4期e015228页
Nickel-containing devices, such as the Amplatzer PFO Occluder and Gore Cardioform Septal Occluder, are used for transcatheter patent foramen ovale closure. However, the impact of nickel hypersensitivity on postprocedural outcomes remains poorly understood. This study aimed to evaluate the risk of adverse events in patients with nickel hypersensitivity undergoing patent foramen ovale closure.
484. Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry.
作者: Josef Stehlik.;Maryjane A Farr.;Mandeep R Mehra.;Jacob N Schroder.;David A D'Alessandro.;Jay D Pal.;Mauricio A Villavicencio.;Peter J Gruber.;Gregory S Couper.;Yasuhiro Shudo.;Parag C Patel.;Mani A Daneshmand.;Liviu Klein.;Ashish S Shah.;Eric R Skipper.;Fardad Esmailian.;Daniel Goldstein.;Suguru Ohira.;Lucian Lozonschi.;David J Kaczorowski.;Koji Takeda.;Rajasekhar S R Malyala.;Jonathan W Haft.;Dan M Meyer.;Benjamin C Sun.;Victor Pretorius.;Arman Kilic.;Anelechi C Anyanwu.;Celeste T Williams.;Duc T Pham.;Masashi Kai.;Nasir Z Sulemanjee.;Akinobu Itoh.;Masaki Funamoto.;Christopher T Salerno.;John S Ikonomidis.;Lucian A Durham.;Andrew Shaffer.;Xiang Zhou.;Farhan Zafar.;Sean P Pinney.;Carmelo A Milano.
来源: Circulation. 2025年151卷13期896-909页
A preservation system, the Organ Care System (OCS; TransMedics) uses normothermic pulsatile perfusion during organ transport for heart transplantation. This system has demonstrated favorable outcomes in hearts recovered from extended-criteria donors after brain death (DBD) and donors after circulatory death (DCD).
485. Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study.
作者: Eloi Gagnon.;Dipender Gill.;Dominique Chabot.;Héléne T Cronjé.;Shuai Yuan.;Stephen Brennan.;Sébastien Thériault.;Stephen Burgess.;Benoit J Arsenault.;Marie-Joe Dib.
来源: Circ Genom Precis Med. 2025年18卷2期e004933页
Therapies targeting the LPL (lipoprotein lipase) pathway are under development for cardiometabolic disease. Insights into their efficacy-both alone and in combination with existing lipid-lowering therapies-modes of action, and safety of these agents are essential to inform clinical development. Using Mendelian randomization, we aimed to (1) evaluate efficacy, (2) explore shared mechanisms, (3) assess additive effects with approved lipid-lowering drugs, and (4) identify secondary indications and potential adverse effects.
486. Harnessing the Plasma Proteome to Predict Mortality in Heart Failure Subpopulations.
作者: Jessica Chadwick.;Michael A Hinterberg.;Folkert W Asselbergs.;Hannah Biegel.;Eric Boersma.;Thomas P Cappola.;Julio A Chirinos.;Joseph Coresh.;Peter Ganz.;David A Gordon.;Natasha Kureshi.;Kelsey M Loupey.;Alena Orlenko.;Rachel Ostroff.;Laura Sampson.;Sama Shrestha.;Nancy K Sweitzer.;Stephen A Williams.;Lei Zhao.;Isabella Kardys.;David E Lanfear.
来源: Circ Heart Fail. 2025年18卷4期e011208页
We derived and validated proteomic risk scores (PRSs) for heart failure (HF) prognosis that provide absolute risk estimates for all-cause mortality within 1 year.
487. Heart Rate Reduction Is Associated With Reverse Left Ventricular Remodeling and Mechanism-Specific Molecular Phenotypes in Dilated Cardiomyopathy.
作者: Natasha L Altman.;Edward A Gill.;Rami Kahwash.;Leslie K Meyer.;Jessica A Wagner.;Anis Karimpour-Fard.;Amber A Berning.;Wayne A Minobe.;Ian A Carroll.;Eric R Jonas.;Dobromir Slavov.;Sitaramesh Emani.;William T Abraham.;Alexa R Gollah.;Samuel L Ellis.;Matthew R G Taylor.;Sharon L Graw.;Luisa Mestroni.;Timothy A McKinsey.;Peter M Buttrick.;David P Kao.;Michael R Bristow.
来源: Circ Heart Fail. 2025年18卷4期e012484页
Heart rate (HR) affects heart failure outcomes, via uncertain mechanisms that may include left ventricular remodeling. However, in human ventricular myocardium, HR change has not been associated with a particular remodeling molecular phenotype.
488. Hemodynamics of Exercise-Induced Hypertension and Relationship to Outcomes in Adults With Coarctation of the Aorta.
作者: Alexander C Egbe.;Yogesh N V Reddy.;William R Miranda.;C Charles Jain.;Heidi M Connolly.;Barry A Borlaug.
来源: Circ Heart Fail. 2025年18卷4期e012459页
Exercise-induced hypertension (EIH) is common in adults with coarctation of the aorta (COA), but there are limited data about hemodynamics and outcomes in such patients. The purpose of this study was to assess changes in arterial load during exercise in patients with COA with versus without EIH, and the relationship to clinical outcomes.
489. Transfer to Hub Hospitals and Outcomes in Cardiogenic Shock.
作者: Shubhadarshini Pawar.;Kannu Bansal.;J Dawn Abbott.;Manreet K Kanwar.;Navin K Kapur.;Van-Khue Ton.;Saraschandra Vallabhajosyula.
来源: Circ Heart Fail. 2025年18卷4期e012477页
There are limited large-scale data on the outcomes of patients with cardiogenic shock (CS) transferred to hub centers. This study aimed to compare the characteristics and outcomes of transferred patients with CS versus those who were not transferred.
491. Early Versus Delayed Invasive Management of Female Patients With Non-ST-Elevation Acute Coronary Syndrome: An Individual Patient Data Meta-Analysis.
作者: Gregory B Mills.;Christos P Kotanidis.;Shamir Mehta.;Denise Tiong.;Erik A Badings.;Thomas Engstrøm.;Arnoud W J van 't Hof.;Dan Høfsten.;Lene Holmvang.;Alexander Jobs.;Lars Køber.;Dejan Milasinovic.;Aleksandra Milosevic.;Goran Stankovic.;Holger Thiele.;Roxana Mehran.;Vijay Kunadian.
来源: Circ Cardiovasc Interv. 2025年18卷3期e014763页
Female patients are at greater risk of adverse events following non-ST-elevation acute coronary syndrome but less frequently receive guideline-recommended coronary angiography and revascularization. Routine invasive management benefits high-risk patients, but evidence informing the optimal timing of angiography specifically in female patients is lacking.
492. Recurrent Cryptogenic Ischemic Strokes in a Young Female Patient: A Case of a Bilateral Carotid Web.
作者: Erica Rocco.;Marco Ciacciarelli.;Salvino Bilancini.;Sonia Ferri.;Alessandro Polidoro.;Marco Rengo.;Beatrice Simeone.;Valentina Valenti.;Sebastiano Sciarretta.;Luigi Iuliano.
来源: Circ Cardiovasc Imaging. 2025年e017819页 494. Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema.
作者: Fabrice Gucciardo.;Alizée Lebeau.;Sébastien Pirson.;Florence Buntinx.;Elitsa Ivanova.;Silvia Blacher.;Pascal Brouillard.;Jonathan Deroye.;Louis Baudin.;Alexandra Pirnay.;Florent Morfoisse.;Claire Villette.;Christophe Nizet.;François Lallemand.;Carine Munaut.;Kari Alitalo.;Liesbet Geris.;Miikka Vikkula.;Marine Gautier-Isola.;Agnès Noel.
来源: Circulation. 2025年151卷19期1412-1429页
Lymphedema is an incurable disease associated with lymphatic dysfunction that causes tissue swelling and fibrosis. We investigated whether lymphedema could be attenuated by interfering with uPARAP (urokinase plasminogen activator receptor-associated protein; Mrc2 gene), an endocytic receptor involved in fibrosis and lymphangiogenesis.
495. Endomyocardial Fibrosis Mimicking a Heart Tumor and Dysplastic Tricuspid Valve in a Teenager: A Rare Cardiac Manifestation of Behçet Disease.
作者: Francesca Sperotto.;Pakaparn Kittichokechai.;Andrew J Powell.;Tal Geva.;Naomi Gauthier.;Joyce C Chang.;Brian D Soriano.;Nikhil Thatte.
来源: Circ Cardiovasc Imaging. 2025年e017064页 |