The safety of morphine in acute pancreatitis (AP) remains controversial due to theoretical risks of exacerbating complications. This study evaluated whether early morphine use correlates with clinical deterioration in AP.

Colorectal cancer (CRC) incidence in Ghana has increased significantly in recent years. Despite medical advances, survival rates remain low, with challenges in CRC screening implementation contributing to late-stage diagnoses and poor outcomes.

Gastrointestinal (GI) motility disorders are characterized by abnormalities in the motor functions of the GI tract. The diagnostic evaluation of these disorders frequently involves invasive and time-consuming examinations, for which access may be limited. Volatile organic compounds (VOCs) could serve as non-invasive alternative. Therefore, the aim of this study was to explore the potential of exhaled breath VOCs as biomarkers in patients with GI symptoms and potential GI motility disorders.

Deep-pelvic Fournier's gangrene (FG) spreading via supralevator abscesses is a rare yet clinically challenging condition, often requiring meticulous surgical intervention to ensure adequate drainage while avoiding critical anatomical injury. Although combined suprapubic and transsacral approaches for extraperitoneal compartment access and linked-loop drainage systems represent innovative strategies, their efficacy and outcomes remain underreported. This study aimed to analyze the clinical outcomes of patients with deep-pelvic Fournier gangrene treated using this dual-approach technique.

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are common tumors of the digestive system. Although their histological diagnosis is usually straightforward, the differential diagnosis between neuroendocrine tumors G3 (NET G3) and neuroendocrine carcinomas (NECs) may be challenging at times due to a similar immunophenotype and morphology in a small number of cases.

The vermiform appendix is prone to various diseases, with acute appendicitis (AA) being the most common. The increasing incidence in Nigeria complicates diagnosis, leading to negative appendectomies. Accurate and timely diagnosis, along with routine histopathological examination, is essential for effective patient care.

The neutrophil to high-density lipoprotein cholesterol ratio (NHR) predicts disease severity in biliary pancreatitis, yet its prognostic role in hypertriglyceridemic acute pancreatitis (HTG-AP) remains unclear.

Autoimmune liver diseases (AILD) are a heterogeneous group of chronic inflammatory conditions characterized by progressive hepatic fibrosis. While liver stiffness measurement (LSM) has emerged as a valuable non-invasive assessment tool, its clinical utility and associated factors in AILD populations remain incompletely characterized, particularly in understudied ethnic populations.

Research exploring the relationship between atrial fibrillation (AF) and acute pancreatitis (AP) is limited. This study aims to explore the association between AF and both the disease severity and in-hospital mortality in AP.

Patients' adherence is important for successful Helicobacter pylori (H. pylori) eradication, and may be improved by WeChat, a popular social networking platform. This study aimed to evaluate patients' adherence, successful H. pylori eradication, and clinical remission under the WeChat-based enhanced guidance.

Radiotherapy remains a valuable yet limited option for select colon cancer cases, with radioresistance representing a major clinical challenge. Lipidomics screening identified autotaxin (ATX), also known as ENPP2, as a key mediator of radiation-induced metabolic reprogramming. Radiation exposure upregulated ATX expression and its product lysophosphatidic acid (LPA), which activated the LPAR2-AKT signaling axis to support tumor cell survival. Pharmacological ATX inhibition with HA130 or genetic ATX knockdown enhanced radiosensitivity in vitro by suppressing proliferation and promoting apoptosis. In mouse models, both HA130 treatment and ATX knockdown significantly suppressed tumor growth and improved radiotherapy efficacy, as shown by reduced tumor volume, weight, and Ki67-positive cell counts. Clinically, elevated ATX-LPA pathway activity was associated with poor patient prognosis. These findings establish ATX as a promising therapeutic target for overcoming radioresistance in colon cancer, supporting the combination of ATX inhibition with radiotherapy to improve treatment outcomes.

Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases. We aimed to conduct a pilot study to evaluate the potential utility of ChatGPT in early diagnosis of MAFLD.

Inflammatory–immune blood indices such as the systemic immune‑inflammation index (SII) relate to outcomes in hepatocellular carcinoma (HCC). Visit‑to‑visit variability (VVV) may capture instability of host inflammatory homeostasis that is not reflected by average levels. We examined whether early VVV of these indices predicts overall survival (OS) and adds discriminatory value beyond standard prognostic factors and mean levels.

This research aimed to assess the relationship between creatinine-to-albumin ratio (CAR) and clinical outcomes among individuals with upper gastrointestinal bleeding (UGIB), with a particular focus on the association between CAR and 30-day and 90-day all-cause mortality (ACM).

Pancreatic cancer (PC) is the third most common cause of cancer-related deaths worldwide, with the 5-year survival rate for patients with PC in developed countries being only 9-10%. Gastroesophageal reflux disease (GERD) is known to be a high-risk factor for several cancers. However, the relationship between GERD and PC remains controversial. Therefore, this study aimed to investigate the causal association between GERD and the risk of PC. Additionally, we sought to validate the role of omega-6/omega-3 polyunsaturated fatty acids (n-6/n-3 PUFA) as mediators in this pathway by calculating their mediating effect.