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361. Endoplasmic reticulum stress enhances unsaturated fatty acid-induced hepatocyte injury in human pluripotent stem cell-derived hepatic culture.
作者: Takuma Araki.;Keiko Yokoyama.;Kinuyo Ida.;Yutaka Inagaki.;Akihide Kamiya.
来源: BMC Gastroenterol. 2026年26卷1期118页
The liver is a central organ involved in lipid metabolism. Hepatocytes synthesize fatty acids and triglycerides under conditions of excess energy while decomposing fats by β-oxidation under conditions of energy deficiency. When fatty acid metabolism is impaired due to metabolic syndrome, excessive lipid accumulation in the liver increases the risk of fatty liver disease, chronic hepatitis, and liver cancer. Excessive fat accumulation causes various types of cell damage, such as oxidative stress, which causes lipotoxicity. There is a difference in lipotoxicity between saturated and unsaturated fatty acids among various fatty acids, and saturated fatty acids are more toxic. However, there are still many unknowns about the role of unsaturated fatty acids in steatohepatitis remains unclear.
362. Acute oesophageal necrosis: single centre experience.
作者: Şehmus Ölmez.;Duran Deha Çetin.;Mustafa Harı.;Abdullah İlhan.;Bünyamin Sarıtaş.
来源: BMC Gastroenterol. 2026年26卷1期115页
Acute oesophageal necrosis (AEN) is a rare but important cause of upper gastrointestinal bleeding (UGIB). The prognosis is poor and related to the presence of concomitant diseases. In this study, we aimed to evaluate the outcomes of patients with AEN.
363. An interpretable machine learning model for prediction of significant liver fibrosis in comorbid chronic hepatitis B and nonalcoholic fatty liver disease: a retrospective development and validation study.
The coexistence of chronic hepatitis B (CHB) and nonalcoholic fatty liver disease (NAFLD) accelerates liver fibrosis progression, but effective noninvasive tools for fibrosis risk assessment in this specific population are lacking. This study aimed to develop and validate an explainable machine learning (ML) model to predict significant liver fibrosis in patients with comorbid CHB and NAFLD.
364. Shared and distinct spontaneous brain activity pattern in crohn's disease and ulcerative colitis: evidence from cortical surface‑based analysis.
作者: Mengting Huang.;Qinyue Luo.;Shuo Huang.;Yuting Zheng.;Yimeng He.;Liangru Zhu.;Ping Han.;Jiawei Wu.;Heshui Shi.
来源: BMC Gastroenterol. 2026年26卷1期112页
Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease (IBD), are associated with emotional disturbances, but their shared and distinct neurobiological substrates remain unclear. This neuroimaging study aimed to characterize shared and distinct patterns of spontaneous neural activity in CD and UC patients using resting-state functional MRI (rs-fMRI).
365. Tofogliflozin attenuates liver steatosis and fibrosis in non-diabetic non-alcoholic steatohepatitis mice.
作者: Yoshinori Ozono.;Hiroshi Kawakami.;Hiroshi Hatada.;Naomi Uchiyama.;Souichiro Ogawa.;Keisuke Uchida.;Hotaka Tamura.;Yuri Komaki.;Kenichi Nakamura.;Hisayoshi Iwakiri.;Satoru Hasuike.;Kenji Nagata.
来源: BMC Gastroenterol. 2026年26卷1期108页
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with increasing global prevalence. Although diabetes is a major factor in NAFLD progression, up to 75% of the patients with NAFLD do not have diabetes. Tofogliflozin (Tofo), a sodium-glucose cotransporter type-2 inhibitor, is widely used in patients with type 2 diabetes. Several clinical trials with Tofo have shown its beneficial effects in NAFLD patients with diabetes; however, currently, there are limited data on NAFLD patients without diabetes.
366. Targeted therapies and their outcomes in monogenic very early onset inflammatory bowel disease: a systematic review.
作者: Amir Parsa Abhari.;Parastesh Rezvanian.;Elika Sohrabi.;Kaveh Hosseini.;Mohamed Attauabi.;Rashee Gupta.;Kimia Najafi.
来源: BMC Gastroenterol. 2026年26卷1期113页
Very early onset inflammatory bowel disease (VEO-IBD) is a rare, severe condition with over 80 monogenic causes. These often resist conventional therapies, necessitating targeted treatments such as biologics and hematopoietic stem cell transplantation (HSCT). This study aimed to systematically review therapeutic outcomes.
367. Comparison of diagnostic value of abdominal obesity and metabolism-related indicators for non-alcoholic fatty liver disease in lean individuals.
作者: Hailong Zhang.;Meng Guo.;Xiao Liang.;Dan Wan.;Chunli Zhang.;Fanfan Liang.;Sijia Chen.;Qian Wang.;Zongfang Li.
来源: BMC Gastroenterol. 2026年26卷1期111页
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease globally. The present study aims to investigate the diagnostic value of abdominal obesity and metabolism-related indicators for NAFLD in lean individuals.
368. A 7-cm inflection point: nonlinear association between maximum tumor diameter and capsular invasion risk after primary liver cancer resection.
作者: Ye Zhang.;Gongming Zhang.;Xin Wang.;Yingmin Ma.;Guangming Li.
来源: BMC Gastroenterol. 2026年26卷1期114页
Capsular invasion independently predicts poor prognosis after primary liver cancer (PLC). While maximum tumor diameter (MTD) informs staging systems, its potential nonlinear association with capsular invasion remains unquantified.
369. Endoscopic balloon dilation for peptic gastroduodenal stenosis with gastric outflow obstruction: effectiveness, durability and early predictors of unsatisfactory outcomes.
作者: Adam Zeyara.;Léonie Scarfone.;Martin Jeremiasen.;Dan Falkenback.;Bodil Andersson.;Bobby Tingstedt.;Jan Johansson.
来源: BMC Gastroenterol. 2026年26卷1期66页
Peptic gastroduodenal stenosis is a rare but disabling condition causing gastric outlet obstruction. This study aimed to evaluate endoscopic balloon dilation in terms of treatment effectiveness, durability, and identify potential early predictors of unsatisfactory outcomes.
370. The role of health, sociodemographic, and care delivery factors in timely completion of colonoscopy in a US-based primary care population: a retrospective analysis.
作者: Talya Salant.;Cancan Zhang.;Catherine M DesRoches.;Russell S Phillips.;Leonor Fernández.
来源: BMC Gastroenterol. 2026年26卷1期110页
Timely colonoscopy completion in primary care can prevent diagnostic delays in colorectal cancer. Factors that influence why patients experience timely or delayed colonoscopy completion are unclear. We sought to identify potentially intervenable factors associated with earlier (or later) colonoscopy test completion in primary care.
371. Effectiveness of the ABC score in predicting 30-day mortality in upper and lower gastrointestinal bleeding at Muhimbili National Hospital, Tanzania: a single-center retrospective cohort study.
作者: Fatima Salaheldin Ahmed.;Beatrice Kombole.;Mohammed Hassan.;Ali Abdelhaleem Omar Ahmed.
来源: BMC Gastroenterol. 2026年26卷1期109页
Gastrointestinal bleeding is a major cause of morbidity and mortality, this study aimed to validate the performance of the new ABC score in predicting 30-day mortality in upper gastrointestinal bleeding (UGIB) and lower gastrointestinal bleeding (LGIB) in a cohort of Tanzanian patients and compare it to existing pre-endoscopy risk scores.
372. The value of platelet-associated parameters as biomarkers in evaluating the disease activity of inflammatory bowel disease: a systematic review and meta-analysis.
作者: Haojie Wang.;Rongrong Shao.;Sa Wu.;Yichen Zhu.;Zijun Zhang.;Mengting Cui.;Manman Xiang.;Shanshan Li.;Fangtian Fan.;Xian Li.;Yu Tao.
来源: BMC Gastroenterol. 2026年26卷1期104页
Developing inflammatory bowel disease (IBD) affects platelet counts (PLT), which are involved in blood coagulation. However, the predictive or diagnostic utility of platelet characteristics in assessing IBD disease activity of inflammatory bowel disease. We conducted thisremains unknown. This meta-analysis was conducted to quantitatively evaluate changes in platelet parameters during the active phase of IBD using a large sample size.
373. Correlation between imaging features and pathological risk of gastric stromal tumors in endoscopic ultrasonography and enhanced computed tomography.
作者: Yu-Hao Wang.;Wen-Sha Huang.;Zu-Nan Wu.;Xiao-Yun Yu.;Hong-Qi Meng.;Lei Shen.;Peng Sun.
来源: BMC Gastroenterol. 2026年26卷1期106页
Endoscopic ultrasonography (EUS) and enhanced computed tomography (CT) can offer more image features of gastric stromal tumors with higher pathological risk, which is of great significance for determining the pathological risk degree of gastric stromal tumors (GSTs) before surgery.
375. Impact of preoperative triglyceride levels on hepatic encephalopathy development in TIPS patients: a retrospective cohort study.
Overt hepatic encephalopathy (OHE) is a common complication following transjugular intrahepatic portosystemic shunt (TIPS) procedures in patients with cirrhosis. However, the relationship between preoperative triglyceride (TG) levels and post-TIPS OHE risk remains unclear. This study aimed to investigate whether elevated preoperative TG levels are independently associated with increased risk of developing OHE following TIPS in patients with cirrhosis.
376. Risk factors for disease severity in hypertriglyceridemic acute pancreatitis: a single-center retrospective study.
作者: Rong-Rong Wei.;Yan Zhou.;Haifeng Yuan.;Lele Zong.;Chengchao Gao.;Donglin Yan.;Dongmei Guo.
来源: BMC Gastroenterol. 2026年26卷1期105页
Hypertriglyceridemia is an increasingly common cause of acute pancreatitis (AP). Patients with hypertriglyceridemic acute pancreatitis (HTG-AP) have higher complication and mortality rates compared to those with other etiologies. Early prediction of disease severity remains challenging due to the lack of readily available tools specifically for HTG-AP.
377. FCRL3 as a potential link between Benzo[a]pyrene exposure and primary biliary cholangitis: insights from comparative toxicogenomics and multi-omics analysis.
作者: Zongze Han.;Ying Ran.;Ruiyun Liu.;Shijing Dong.;Jiwen Li.;Xue Zhang.;Nian Chen.;Can Wang.;Bangmao Wang.;Simin Zhou.;Lu Zhou.
来源: BMC Gastroenterol. 2026年26卷1期101页
Exposure to Benzo[a]pyrene (BaP) is linked to multiple autoimmune diseases. This study aims to identify the key genes associated with BaP exposure and primary biliary cholangitis (PBC), shedding light on the underlying molecular mechanisms.
378. Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis.
作者: Anna K Sommer.;Iris B A W Te Paske.;Erik A M Jansen.;Axel Gschwind.;German Demidov.;Verena Steinke-Lange.;Isabel Spier.;Wouter Steyaert.;Burcu Yaldiz.;Marloes Steehouwer.;Oliver Hommerding.;Dimo Dietrich.;Sophia Peters.;José Garcia-Pelaez.;Andreas Laner.;Carla Oliveira.;Gabriel Capellá.;Iris D Nagtegaal.;Hendrik Bläker.;Kornelia Ellwanger.;Alexander Hoischen.;Christian Gilissen.;Rachel S van der Post.;Glen Kristiansen.;Nicoline Hoogerbrugge.;Stephan Ossowski.;Laura Valle.;Elke Holinski-Feder.;Marjolijn J L Ligtenberg.;Stefan Aretz.;Richarda M de Voer.
来源: Gastroenterology. 2026年170卷3期557-568页
Individuals with colorectal polyposis are suspected to be genetically predisposed to tumor development. However, in around half of adenomatous and the vast majority of serrated polyposis patients, no explanatory pathogenic germline variant is found in routine diagnostics. Here, we aimed to improve the characterization of the early steps of polyp formation and provide clues on the tumorigenic processes involved.
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