3691. Adverse Effects of Low-Dose Methotrexate: A Randomized Trial.
作者: Daniel H Solomon.;Robert J Glynn.;Elizabeth W Karlson.;Fengxin Lu.;Cassandra Corrigan.;Josh Colls.;Chang Xu.;Jean MacFadyen.;Medha Barbhaiya.;Nancy Berliner.;Paul F Dellaripa.;Brendan M Everett.;Aruna D Pradhan.;Sarah P Hammond.;Meredith Murray.;Deepak A Rao.;Susan Y Ritter.;Anna Rutherford.;Jeffrey A Sparks.;Jackie Stratton.;Dong H Suh.;Sara K Tedeschi.;Kathleen M M Vanni.;Nina P Paynter.;Paul M Ridker.
来源: Ann Intern Med. 2020年172卷6期369-380页
Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis. Despite extensive clinical use for more than 30 years, few data on adverse event (AE) rates derive from randomized, placebo-controlled trials, where both causality and magnitude of risk can be inferred.
3692. The Management of Chronic Insomnia Disorder and Obstructive Sleep Apnea: Synopsis of the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines.
作者: Vincent Mysliwiec.;Jennifer L Martin.;Christi S Ulmer.;Susmita Chowdhuri.;Matthew S Brock.;Christopher Spevak.;James Sall.
来源: Ann Intern Med. 2020年172卷5期325-336页
In September 2019, the U.S. Department of Veterans Affairs (VA) and the U.S. Department of Defense (DoD) approved a new joint clinical practice guideline for assessing and managing patients with chronic insomnia disorder and obstructive sleep apnea (OSA). This guideline is intended to give health care teams a framework by which to screen, evaluate, treat, and manage the individual needs and preferences of VA and DoD patients with either of these conditions.
3697. Poxvirus Vectored Cytomegalovirus Vaccine to Prevent Cytomegalovirus Viremia in Transplant Recipients: A Phase 2, Randomized Clinical Trial.
作者: Ibrahim Aldoss.;Corinna La Rosa.;Lindsey R Baden.;Jeffrey Longmate.;Ella J Ariza-Heredia.;Wasima N Rida.;Chetan Raj Lingaraju.;Qiao Zhou.;Joy Martinez.;Teodora Kaltcheva.;Andy Dagis.;Nicola Hardwick.;Nicolas C Issa.;Len Farol.;Auayporn Nademanee.;Monzr M Al Malki.;Stephen Forman.;Ryotaro Nakamura.;Don J Diamond.; .
来源: Ann Intern Med. 2020年172卷5期306-316页
Triplex vaccine was developed to enhance cytomegalovirus (CMV)-specific T cells and prevent CMV reactivation early after hematopoietic stem cell transplant (HCT).
3698. Addition of Maraviroc Versus Placebo to Standard Antiretroviral Therapy for Initial Treatment of Advanced HIV Infection: A Randomized Trial.
作者: Yves Lévy.;Jean-Daniel Lelièvre.;Lambert Assoumou.;Esther Aznar.;Federico Pulido.;Giuseppe Tambussi.;Manuel Crespo.;Agnès Meybeck.;Jean-Michel Molina.;Constance Delaugerre.;Jacques Izopet.;Gilles Peytavin.;Fanny Cardon.;Alpha Diallo.;Rémi Lancar.;Lydie Béniguel.;Dominique Costagliola.
来源: Ann Intern Med. 2020年172卷5期297-305页
Patients diagnosed with advanced HIV infection have a poor prognosis despite initiation of combined antiretroviral therapy (c-ART).
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