Complete renal response (CRR) is a primary goal in lupus nephritis (LN) management. We examined the prevalence and predictors of sustained CRR (sCRR) and long-term outcomes.

To evaluate the efficacy of glucocorticoid-sparing management in patients with G-CSF-associated large-vessel vasculitis (LVV).

Patient education is increasingly acknowledged as an important aspect of the management of systemic lupus erythematosus (SLE). The aim of the study was to develop the SLE Knowledge Assessment score (SLAKE), a digital multilingual self-assessment tool designed to quantify essential SLE knowledge.

To assess efficacy of voclosporin (VCL) from a retrospective, observational, clinical-practice-based, nationwide multicentre study of patients with LN.

This study aimed to estimate the incidence of adverse pregnancy outcomes (APO) in patients with systemic lupus erythematosus (SLE) and to evaluate the risks associated with immunosuppressant use-including hydroxychloroquine and teratogenic agents such as mycophenolate mofetil, methotrexate and cyclophosphamide-across specific APO categories.

To assess the prevalence and factors associated with discordance between patient and physician global assessments (PaGA and PGA) of SLE disease activity over time, and explore residual patient-perceived burden during remission.

Pulmonary manifestations of CTDs are associated with morbidity and mortality. Early recognition through screening ensures appropriate monitoring and management. The aim of this audit was to define standards for pulmonary screening in CTDs and assess practice in UK tertiary paediatric rheumatology centres.

The neural mechanisms underlying salience network (SN) dysfunction in SLE remain unclear. This study applied a comprehensive multimodal approach to characterize SN abnormalities in SLE patients.

TNF is a central regulator of immune responses, inflammation and programmed cell death, and has an essential role in maintaining tissue and immune homeostasis. Abnormal TNF signalling is implicated in a broad spectrum of physiological and pathological processes, as exemplified by monogenic disorders arising from dysregulation of core components of the TNF pathway. These rare conditions encompass various autoinflammatory syndromes, immunodeficiencies, autoimmune diseases and neurodegenerative conditions, and offer unique insights into the molecular mechanisms driving pathology via TNF-mediated inflammation and cell death. Collectively, these diseases underscore the importance of tightly regulated TNF signalling for immune balance and illustrate how distinct molecular defects can produce overlapping clinical phenotypes. Variability in pathway integration and tissue-specific gene expression further shapes disease presentation, whereas disruption of post-translational modifications and cell-death regulators have emerged as central pathogenic mechanisms. Together, these insights highlight the need for precise genetic and mechanistic understanding to inform diagnosis and therapeutic strategies.

Erosive hand osteoarthritis is a painful and inflammatory disease without effective treatments. In this study we aimed to investigate the efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) compared with sham stimulation in patients with inflammatory erosive hand osteoarthritis.

Dual blockade of IL-4 and IL-13 in atopic dermatitis (AD) has been associated with activation of the IL-23/IL-17 axis, potentially leading to paradoxical psoriasis and PsA-like presentation. However, the specific cytokine responsible for these reactions remains unclear. We report a case series of PsA-like presentation following treatment with tralokinumab, an anti-IL-13 monoclonal antibody used for AD.

H syndrome is a rare autosomal recessive disorder caused by mutations in SLC29A3, encoding the nucleoside transporter hENT3. Its heterogeneous clinical presentation often includes skin hyperpigmentation, systemic inflammation, endocrinopathies and sensorineural hearing loss. However, typical cutaneous signs may be absent, leading to diagnostic challenges. The objective was to describe a patient with H syndrome misdiagnosed until adulthood as having cryopyrin-associated periodic syndrome (CAPS), due to overlapping clinical and functional features.

To assess the prevalence of aortitis and aortic dilation at diagnosis, estimate the progression of aortic diameter over time, and identify predictors of incident aortic dilation development in patients with newly diagnosed GCA.

This study evaluated the classification utility of incorporating parotid gland US for juvenile Sjögren's disease (jSjD) by testing its role in a weighted scoring (WS) model and comparing it with the standard 2016 ACR/EULAR classic model (CM).