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3341. Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? : A Systematic Review.
作者: Aaron P Mitchell.;Niti U Trivedi.;Renee L Gennarelli.;Susan Chimonas.;Sara M Tabatabai.;Johanna Goldberg.;Luis A Diaz.;Deborah Korenstein.
来源: Ann Intern Med. 2021年174卷3期353-361页
Financial payments from the drug industry to U.S. physicians are common. Payments may influence physicians' clinical decision making and drug prescribing.
3344. Probability of Success and Timelines for the Development of Vaccines for Emerging and Reemerged Viral Infectious Diseases.
作者: Amanda MacPherson.;Nora Hutchinson.;Oliver Schneider.;Elisabeth Oliviero.;Emma Feldhake.;Charlotte Ouimet.;Jacky Sheng.;Fareed Awan.;Catherine Wang.;Jesse Papenburg.;Nicole E Basta.;Jonathan Kimmelman.
来源: Ann Intern Med. 2021年174卷3期326-334页
Anticipated success rates and timelines for COVID-19 vaccine development vary. Recent experience with developing and testing viral vaccine candidates can inform expectations regarding the development of safe and effective vaccines.
3345. Ethical and Scientific Considerations Regarding the Early Approval and Deployment of a COVID-19 Vaccine.
作者: Rafael Dal-Ré.;Arthur L Caplan.;Christian Gluud.;Raphaël Porcher.
来源: Ann Intern Med. 2021年174卷2期258-260页
This commentary discusses the early licensing and deployment of a COVID-19 vaccine and how accomplishing this goal could compromise ethical principles that guide clinical research.
3346. The Role of Masks in Mitigating the SARS-CoV-2 Pandemic: Another Piece of the Puzzle.
Bundgaard and colleagues report the results of a unique randomized controlled trial of mask wearing in the community to mitigate SARS-CoV-2 infection. The editorialists discuss how the findings add to what we know about mask wearing in the community and risk for SARS-CoV-2 infection.
3347. Of Masks and Methods.
In their article, Bundgaard and colleagues report the results of a unique randomized controlled trial of masks in the community to mitigate SARS-CoV-2 infection. The trial addresses the question of personal protection to mask wearers when others are not wearing masks and not the question of the effectiveness of widespread mask wearing in reducing community transmission. The editorialists discuss the findings and their concerns about the trial design.
3348. Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers : A Randomized Controlled Trial.
作者: Henning Bundgaard.;Johan Skov Bundgaard.;Daniel Emil Tadeusz Raaschou-Pedersen.;Christian von Buchwald.;Tobias Todsen.;Jakob Boesgaard Norsk.;Mia M Pries-Heje.;Christoffer Rasmus Vissing.;Pernille B Nielsen.;Ulrik C Winsløw.;Kamille Fogh.;Rasmus Hasselbalch.;Jonas H Kristensen.;Anna Ringgaard.;Mikkel Porsborg Andersen.;Nicole Bakkegård Goecke.;Ramona Trebbien.;Kerstin Skovgaard.;Thomas Benfield.;Henrik Ullum.;Christian Torp-Pedersen.;Kasper Iversen.
来源: Ann Intern Med. 2021年174卷3期335-343页
Observational evidence suggests that mask wearing mitigates transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is uncertain if this observed association arises through protection of uninfected wearers (protective effect), via reduced transmission from infected mask wearers (source control), or both.
3350. Telemedicine and Office-Based Care for Behavioral and Psychiatric Conditions During the COVID-19 Pandemic in the United States.
作者: Omar Mansour.;Matthew Tajanlangit.;James Heyward.;Ramin Mojtabai.;G Caleb Alexander.
来源: Ann Intern Med. 2021年174卷3期428-430页 3351. Long-Term Oncologic Outcomes After Laparoscopic Versus Open Resection for Colorectal Liver Metastases : A Randomized Trial.
作者: Davit L Aghayan.;Airazat M Kazaryan.;Vegar Johansen Dagenborg.;Bård I Røsok.;Morten Wang Fagerland.;Gudrun Maria Waaler Bjørnelv.;Ronny Kristiansen.;Kjersti Flatmark.;Åsmund Avdem Fretland.;Bjørn Edwin.; .
来源: Ann Intern Med. 2021年174卷2期175-182页
Despite the recent worldwide dissemination of laparoscopic liver surgery, no high-level evidence supports the oncologic safety of this approach.
3352. Insights From Rapid Deployment of a "Virtual Hospital" as Standard Care During the COVID-19 Pandemic.
作者: Kranthi Sitammagari.;Stephanie Murphy.;Marc Kowalkowski.;Shih-Hsiung Chou.;Matthew Sullivan.;Stephanie Taylor.;James Kearns.;Thomas Batchelor.;Carly Rivet.;Colleen Hole.;Tony Hinson.;Pamela McCreary.;Ryan Brown.;Todd Dunn.;Zeev Neuwirth.;Andrew McWilliams.
来源: Ann Intern Med. 2021年174卷2期192-199页
Pandemics disrupt traditional health care operations by overwhelming system resource capacity but also create opportunities for care innovation.
3355. Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate : A Cross-sectional Analysis of Pooled Data.
作者: Hans Pottel.;Jonas Björk.;Marie Courbebaisse.;Lionel Couzi.;Natalie Ebert.;Björn O Eriksen.;R Neil Dalton.;Laurence Dubourg.;François Gaillard.;Cyril Garrouste.;Anders Grubb.;Lola Jacquemont.;Magnus Hansson.;Nassim Kamar.;Edmund J Lamb.;Christophe Legendre.;Karin Littmann.;Christophe Mariat.;Toralf Melsom.;Lionel Rostaing.;Andrew D Rule.;Elke Schaeffner.;Per-Ola Sundin.;Stephen Turner.;Arend Bökenkamp.;Ulla Berg.;Kajsa Åsling-Monemi.;Luciano Selistre.;Anna Åkesson.;Anders Larsson.;Ulf Nyman.;Pierre Delanaye.
来源: Ann Intern Med. 2021年174卷2期183-191页
The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for adults are recommended serum creatinine (SCr)-based calculations for estimating glomerular filtration rate (GFR). However, these equations, as well as their combination, have limitations, notably the problem of implausible changes in GFR during the transition from adolescence to adulthood and overestimation of GFR in young adults. The full age spectrum (FAS) equation addresses these issues but overestimates GFR when SCr levels are low.
3357. Diabetes Management in Chronic Kidney Disease: Synopsis of the 2020 KDIGO Clinical Practice Guideline.
作者: Sankar D Navaneethan.;Sophia Zoungas.;M Luiza Caramori.;Juliana C N Chan.;Hiddo J L Heerspink.;Clint Hurst.;Adrian Liew.;Erin D Michos.;Wasiu A Olowu.;Tami Sadusky.;Nikhil Tandon.;Katherine R Tuttle.;Christoph Wanner.;Katy G Wilkens.;Lyubov Lytvyn.;Jonathan C Craig.;David J Tunnicliffe.;Martin Howell.;Marcello Tonelli.;Michael Cheung.;Amy Earley.;Peter Rossing.;Ian H de Boer.;Kamlesh Khunti.
来源: Ann Intern Med. 2021年174卷3期385-394页
The Kidney Disease: Improving Global Outcomes (KDIGO) organization developed a clinical practice guideline in 2020 for the management of patients with diabetes and chronic kidney disease (CKD).
3358. Emergency Approvals for COVID-19: Evolving Impact on Obligations to Patients in Clinical Care and Research.
作者: Holly Fernandez Lynch.;Alison Bateman-House.;Steven Joffe.
来源: Ann Intern Med. 2021年174卷2期256-257页
There currently is debate regarding whether U.S. institutions and clinicians may or should restrict patient access to COVID-19 drugs and vaccines that have been granted emergency use authorization by the U.S. Food and Drug Administration. The authors provide their views on the legal, ethical, and clinical ramifications of such restriction.
3359. A Health Opportunity Cost Threshold for Cost-Effectiveness Analysis in the United States.
Cost-effectiveness analysis is an important tool for informing treatment coverage and pricing decisions, yet no consensus exists about what threshold for the incremental cost-effectiveness ratio (ICER) in dollars per quality-adjusted life-year (QALY) gained indicates whether treatments are likely to be cost-effective in the United States.
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