3301. Newly prescribed canagliflozin vs. GLP-1 agonists was linked to amputation in older adults with type 2 DM and CVD.
Fralick M, Kim SC, Schneeweiss S, et al. Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study. BMJ. 2020;370:m2812. 32843476.
3303. In older patients with AF, low-dose edoxaban reduced stroke or systemic embolism without increasing major bleeding.
Okumura K, Akao M, Yoshida T, et al. Low-dose edoxaban in very elderly patients with atrial fibrillation. N Engl J Med. 2020;383:1735-45. 32865374.
3304. In patients with early AF and CV conditions, early rhythm-control therapy vs. usual care reduced CV events at 5 years.
Kirchhof P, Camm AJ, Goette A, et al. Early rhythm-control therapy in patients with atrial fibrillation. N Engl J Med. 2020;383:1305-16. 32865375.
3305. In severe COVID-19, adding lopinavir-ritonavir to usual care did not improve mortality at 28 days.
RECOVERY Collaborative Group. Lopinavir-ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2020;396:1345-52. 33031764.
3306. Daily aspirin for primary prevention increased risk for major GI bleeding in healthy older adults.
Mahady SE, Margolis KL, Chan A, et al. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut. 2020. [Epub ahead of print.] 32747412.
3307. Stepped Exercise Program for Patients With Knee Osteoarthritis : A Randomized Controlled Trial.
作者: Kelli D Allen.;Sandra Woolson.;Helen M Hoenig.;Dennis Bongiorni.;James Byrd.;Kevin Caves.;Katherine S Hall.;Bryan Heiderscheit.;Nancy Jo Hodges.;Kim M Huffman.;Miriam C Morey.;Shalini Ramasunder.;Herbert Severson.;Courtney Van Houtven.;Lauren M Abbate.;Cynthia J Coffman.
来源: Ann Intern Med. 2021年174卷3期298-307页
Evidence-based models are needed to deliver exercise-related services for knee osteoarthritis efficiently and according to patient needs.
3308. Masks and Face Coverings for the Lay Public : A Narrative Update.
作者: Thomas Czypionka.;Trisha Greenhalgh.;Dirk Bassler.;Manuel B Bryant.
来源: Ann Intern Med. 2021年174卷4期511-520页
Whether and when to mandate the wearing of facemasks in the community to prevent the spread of coronavirus disease 2019 remains controversial. Published literature across disciplines about the role of masks in mitigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is summarized. Growing evidence that SARS-CoV-2 is airborne indicates that infection control interventions must go beyond contact and droplet measures (such as handwashing and cleaning surfaces) and attend to masking and ventilation. Observational evidence suggests that masks work mainly by source control (preventing infected persons from transmitting the virus to others), but laboratory studies of mask filtration properties suggest that they could also provide some protection to wearers (protective effect). Even small reductions in individual transmission could lead to substantial reductions in population spread. To date, only 1 randomized controlled trial has examined a community mask recommendation. This trial did not identify a significant protective effect and was not designed to evaluate source control. Filtration properties and comfort vary widely across mask types. Masks may cause discomfort and communication difficulties. However, there is no evidence that masks result in significant physiologic decompensation or that risk compensation and fomite transmission are associated with mask wearing. The psychological effects of masks are culturally shaped; they may include threats to autonomy, social relatedness, and competence. Evidence suggests that the potential benefits of wearing masks likely outweigh the potential harms when SARS-CoV-2 is spreading in a community. However, mask mandates involve a tradeoff with personal freedom, so such policies should be pursued only if the threat is substantial and mitigation of spread cannot be achieved through other means.
3311. Testing for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans : A Retrospective Cohort Study.
作者: Jordana B Cohen.;Debbie L Cohen.;Daniel S Herman.;John T Leppert.;James Brian Byrd.;Vivek Bhalla.
来源: Ann Intern Med. 2021年174卷3期289-297页
Primary aldosteronism is a common cause of treatment-resistant hypertension. However, evidence from local health systems suggests low rates of testing for primary aldosteronism.
3313. Spillover Effects of Medicare's Voluntary Bundled Payments for Joint Replacement Surgery to Patients Insured by Commercial Health Plans.
作者: Amol S Navathe.;Joshua M Liao.;Kristin A Linn.;Yi Zhang.;Akriti Mishra.;Robin Wang.;Claire T Dinh.;Jingsan Zhu.;Deborah S Cousins.;Jacob Lindner.;Ezekiel J Emanuel.
来源: Ann Intern Med. 2021年174卷2期200-208页
Under the Bundled Payments for Care Improvement (BPCI) program, bundled paymtents for lower-extremity joint replacement (LEJR) are associated with 2% to 4% cost savings with stable quality among Medicare fee-for-service beneficiaries. However, BPCI may prompt practice changes that benefit all patients, not just fee-for-service beneficiaries.
3315. College Campuses and COVID-19 Mitigation: Clinical and Economic Value.
作者: Elena Losina.;Valia Leifer.;Lucia Millham.;Christopher Panella.;Emily P Hyle.;Amir M Mohareb.;Anne M Neilan.;Andrea L Ciaranello.;Pooyan Kazemian.;Kenneth A Freedberg.
来源: Ann Intern Med. 2021年174卷4期472-483页
Colleges in the United States are determining how to operate safely amid the coronavirus disease 2019 (COVID-19) pandemic.
3317. Comparison of Knowledge and Information-Seeking Behavior After General COVID-19 Public Health Messages and Messages Tailored for Black and Latinx Communities : A Randomized Controlled Trial.
作者: Marcella Alsan.;Fatima Cody Stanford.;Abhijit Banerjee.;Emily Breza.;Arun G Chandrasekhar.;Sarah Eichmeyer.;Paul Goldsmith-Pinkham.;Lucy Ogbu-Nwobodo.;Benjamin A Olken.;Carlos Torres.;Anirudh Sankar.;Pierre-Luc Vautrey.;Esther Duflo.
来源: Ann Intern Med. 2021年174卷4期484-492页
The paucity of public health messages that directly address communities of color might contribute to racial and ethnic disparities in knowledge and behavior related to coronavirus disease 2019 (COVID-19).
3318. Messages to Increase COVID-19 Knowledge in Communities of Color: What Matters Most?
In their recent study, Alsan and colleagues explored the relationship between aspects of COVID-19 messaging and African American and Latinx participants' knowledge and information-seeking behavior. The editorialists discuss the findings as well as strategies to improve the effectiveness of public health messages.
3319. Impact of Population Growth and Aging on Estimates of Excess U.S. Deaths During the COVID-19 Pandemic, March to August 2020.
作者: Meredith S Shiels.;Jonas S Almeida.;Montserrat García-Closas.;Paul S Albert.;Neal D Freedman.;Amy Berrington de González.
来源: Ann Intern Med. 2021年174卷4期437-443页
Excess death estimates quantify the full impact of the coronavirus disease 2019 (COVID-19) pandemic. Widely reported U.S. excess death estimates have not accounted for recent population changes, especially increases in the population older than 65 years.
3320. Contributions of Adenocarcinoma and Carcinoid Tumors to Early-Onset Colorectal Cancer Incidence Rates in the United States.
作者: Eric M Montminy.;Meijiao Zhou.;Lauren Maniscalco.;Wesal Abualkhair.;Michelle Kang Kim.;Rebecca L Siegel.;Xiao-Cheng Wu.;Steven H Itzkowitz.;Jordan J Karlitz.
来源: Ann Intern Med. 2021年174卷2期157-166页
Early-onset colorectal cancer (EOCRC) incidence rates (IRs) are rising, according to previous cancer registry analyses. However, analysis of histologic subtypes, including adenocarcinoma (the focus of CRC screening and diagnostic testing) and carcinoid tumors (which are classified as "colorectal cancer" in SEER [Surveillance, Epidemiology, and End Results] databases but have a distinct pathogenesis and are managed differently from adenocarcinoma), has not been reported.
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