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3275. SARS-CoV-2 Vaccines: Much Accomplished, Much to Learn.
作者: Mark Connors.;Barney S Graham.;H Clifford Lane.;Anthony S Fauci.
来源: Ann Intern Med. 2021年174卷5期687-690页
As COVID vaccines roll out, internists and other health care providers are being turned to as trusted sources of information for patients and communities. Here, experts from NIAID outline the current state of knowledge regarding such vaccines. They contrast vaccine platforms, summarize clinical trial data regarding efficacy and safety, and comment on key questions including the ability of current vaccines to protect against infection and to decrease the prevalence of virus in the community.
3277. Cases in Precision Medicine: Genetic Testing to Predict Future Risk for Disease in a Healthy Patient.
作者: Hila Milo Rasouly.;Vimla Aggarwal.;Louise Bier.;David B Goldstein.;Ali G Gharavi.
来源: Ann Intern Med. 2021年174卷4期540-547页
Genetic testing is performed more routinely in clinical practice, and direct-to-consumer tests are widely available. It has obvious appeal as a preventive health measure. Clinicians and their healthy patients increasingly inquire about genetic testing as a tool for predicting diseases, such as cancer, heart disease, or dementia. Despite demonstrated utility for diagnosis in the setting of many diseases, genetic testing still has many limitations as a predictive tool for healthy persons. This article uses a hypothetical case to review key considerations for predictive genetic testing.
3279. Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States.
作者: George L Anesi.;Juliane Jablonski.;Michael O Harhay.;Joshua H Atkins.;Jasmeet Bajaj.;Cameron Baston.;Patrick J Brennan.;Christina L Candeloro.;Lauren M Catalano.;Maurizio F Cereda.;John M Chandler.;Jason D Christie.;Tara Collins.;Katherine R Courtright.;Barry D Fuchs.;Emily Gordon.;John C Greenwood.;Steven Gudowski.;Asaf Hanish.;C William Hanson.;Monica Heuer.;Paul Kinniry.;Zev Noah Kornfield.;Gregory B Kruse.;Meghan Lane-Fall.;Niels D Martin.;Mark E Mikkelsen.;Dan Negoianu.;Jose L Pascual.;Maulik B Patel.;Steven C Pugliese.;Zaffer A Qasim.;John P Reilly.;John Salmon.;William D Schweickert.;Michael J Scott.;Michael G S Shashaty.;Corinna P Sicoutris.;John K Wang.;Wei Wang.;Arshad A Wani.;Brian J Anderson.;Jacob T Gutsche.
来源: Ann Intern Med. 2021年174卷5期613-621页
The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally.
3280. The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasopharyngeal Swabs : A Systematic Review and Meta-analysis.
作者: Mayara Lisboa Bastos.;Sara Perlman-Arrow.;Dick Menzies.;Jonathon R Campbell.
来源: Ann Intern Med. 2021年174卷4期501-510页
Nasopharyngeal swabs are the primary sampling method used for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but they require a trained health care professional and extensive personal protective equipment.
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