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302. Thrombospondin-2 is a performant biomarker of at-risk MASH and advanced MASH fibrosis in a large multicentre European cohort.
作者: Vlad Ratziu.;Rambabu Surabattula.;Elisabetta Bugianesi.;Jörn M Schattenberg.;Sudha Myneni.;Chiara Rosso.;Angelo Armandi.;Raluca Pais.;Leila Kara.;Frédéric Charlotte.;Maharajah Ponnaiah.;Detlef Schuppan.
来源: Gut. 2025年
Non-invasive biomarkers with biological rationale are needed for identifying patients with progressive metabolic dysfunction-associated steatohepatitis (MASH).
303. Real-world impact of implementing lumen-apposing metal stents for pancreatic fluid collections: a nationwide Japanese study.
作者: Tsuyoshi Hamada.;Nobuaki Michihata.;Tomotaka Saito.;Yuya Kimura.;Takuji Iwashita.;Hiroki Matsui.;Hideyuki Shiomi.;Mamoru Takenaka.;Keisuke Iwata.;Akinori Maruta.;Atsuhiro Masuda.;Saburo Matsubara.;Kiyohide Fushimi.;Ichiro Yasuda.;Hiroyuki Isayama.;Hideo Yasunaga.;Yousuke Nakai.; .
来源: Gut. 2025年
Lumen-apposing metal stents (LAMSs) are increasingly used for the endoscopic management of pancreatic fluid collections (PFCs), including walled-off necrosis (WON) and pancreatic pseudocysts (PCs).
305. Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies.
作者: Jinjin Luo.;Meiqian Hu.;Tingting Feng.;Liyuan Zhang.;Yan Huang.;Yuxian Huang.;Feng Ye.;Jiang Li.;Ferran Aguilar.;Cristina Sánchez-Garrido.;Eva Usón-Raposo.;Bing Zhu.;Qian Zhou.;Xi Liang.;Jiaqi Li.;Peng Li.;Jiaojiao Xin.;Dongyan Shi.;Jianming Zheng.;Huafen Zhang.;Baoju Wang.;Wei Qiang.;Heng Yao.;Xingping Zhou.;Jiaxian Chen.;Wen Hu.;Bingqi Li.;Shiwen Ma.;Xiao Wu.;Xiao Li.;Yuheng Kong.;Feiyang Sun.;Xi Chen.;Tianzhou Wu.;Lingling Yang.;Suwan Sun.;Beibei Guo.;Lulu He.;Jinjun Chen.;Shaojie Xin.;Xue Li.;Huazhong Chen.;Paolo Angeli.;Rajiv Jalan.;Bingliang Lin.;Yu Chen.;Shaoli You.;Xin Chen.;Alberto Queiroz Farias.;Jonel Trebicka.;Jing Jiang.;Richard Moreau.;Jun Li.; .; .
来源: Gut. 2025年75卷1期131-146页
Acute-on-chronic liver failure (ACLF) of various aetiologies is a complex syndrome with high short-term mortality and significant global burden.
306. Recent advances in clinical practice endohepatology: the endoscopic liver rush.
作者: Emma Vanderschueren.;Michael Praktiknjo.;Reiner Wiest.;Andres Cardenas.;Jonel Trebicka.;Wim Laleman.
来源: Gut. 2025年74卷11期1916-1930页
The integration of advanced endoscopy within the practice of hepatology is nowadays heralded in the concept of 'endohepatology' and is dichotomised in applications intervening for disorders of the hepatic parenchyma and vasculature and for biliary tract disease. Current applications under the umbrella of endohepatology focus on advanced diagnostics and vascular, metabolic and hepatobiliary interventions. These involve, among others, endoscopic ultrasound (EUS)-guided liver biopsy, EUS-guided portal pressure gradient measurement, coil and glue embolisation of gastric varices and spontaneous portosystemic shunts, artificial-assisted cholangioscopy.In this review, we aim to focus on different applications within endohepatology which are at the benchtop (or coming close by) and attempt to prognosticate potential future techniques within this rapidly evolving field.
308. Pericyte drives the formation of circulating tumour cell-neutrophil clusters to promote colorectal cancer metastasis.
作者: Sheng Wang.;Geni Ye.;Xiaoling Xu.;Yuning Lin.;Xiaobo Li.;Zhang Zhang.;Ming Qi.;Lin Tan.;Minjing Cheng.;Haishan Zhang.;Jinghua Pan.;Changwei Lin.;Dandan Huang.;Rong Deng.;Xiaomei Li.;Guangsuo Wang.;Shenghui Qiu.;Xiaodong Chu.;Yuhong Chen.;Huhu Zeng.;Junqiu Zhang.;Chenran Wang.;Hanlin Shuai.;Changzheng Shi.;Xia Yuan.;Yihai Cao.;Minfeng Chen.;Maohua Huang.;Wencai Ye.;Dongmei Zhang.
来源: Gut. 2025年75卷1期81-93页
Circulating tumour cell (CTC)-neutrophil clusters represent a key driver and a hallmark of tumour metastasis; however, efficient approaches for their elimination are still lacking.
310. Mitochondrial dysfunction drives basal cell hyperplasia in eosinophilic oesophagitis.
作者: Masaki Morimoto.;Kento Kawasaki.;Niamh McNamee.;Samuel Flashner.;Rieko Shimonosono.;Masataka Shimonosono.;Norihiro Matsuura.;Yasuto Tomita.;Wataru Hirose.;Ryugo Teranishi.;Takefumi Itami.;Manti Guha.;Pavithra Rajagopalan.;Cecilia Martin.;Hailey Golden.;Diya Dhakal.;Benjamin J Wilkins.;Andres J Klein-Szanto.;Kirk J Wangensteen.;Julian A Abrams.;Sydney Pomenti.;David A Katzka.;Jianwen Que.;Kelly A Whelan.;Amanda B Muir.;Hirohito Kita.;Benjamin L Wright.;Alfred D Doyle.;Hiroshi Nakagawa.;Uma M Sachdeva.
来源: Gut. 2025年74卷10期1571-1588页
Eosinophilic oesophagitis (EoE) is a food allergen-induced inflammatory disorder characterised by interleukin (IL)-13-mediated oesophageal inflammation and epithelial basal cell hyperplasia (BCH). The role of mitochondria in EoE pathogenesis remains elusive.
312. How accurate is EUS-guided direct portal vein pressure measurement? A comparison with intraoperative measurements.
作者: Aniruddha Pratap Singh.;Zaheer Nabi.;Anand Kulkarni.;Shujaath Asif.;Nitin Jagtap.;Sana Fatima Memon.;Pradev Inavolu.;Priscilla Lopez.;Mithun Sharma.;Hardik Rughwani.;G V Prem.;Bala Chandran.;Kumar Swamy.;Mohan Ramchandani.;D Nageshwar Reddy.;Sundeep Lakhtakia.
来源: Gut. 2025年 313. Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea.
作者: Christopher A Bannon.;Julian R F Walters.;Tongzhi Wu.;Richard G Kay.;Austin Punnoose.;Robin C Spiller.;Jonathan Wilson.;Petra Verdino.;Peter Barker.;Keith Burling.;Michael Horowitz.;Christopher K Rayner.;Alexander C Ford.;Frank Reimann.;Fiona M Gribble.
来源: Gut. 2026年75卷2期278-288页
Insulin-like peptide 5 (INSL5) is an enteroendocrine hormone expressed in distal colonic 'L cells'. Bile acid receptor agonists are known to stimulate INSL5 secretion in primary cell culture, and administration of an INSL5 analogue in animals promotes colonic motility.
315. Targeting Treg-fibroblast interaction to enhance immunotherapy in steatotic liver disease-related hepatocellular carcinoma.
作者: Aldo Prawira.;Hang Xu.;Yu Mei.;Wei Qiang Leow.;Nurul Jannah Mohamed Nasir.;Marie Jy Reolo.;Masayuki Otsuka.;Mohammad Rahbari.;Ziyao Chen.;Madhushanee Weerasooriya.;Liyana Bte Abdullah.;Jiawei Wu.;Sharifah N Hazirah.;Martin Wasser.;Alexander Chung.;Brian Kp Goh.;Pierce Kh Chow.;Salvatore Albani.;Joycelyn Lee.;Tony Kiat Hon Lim.;Weiwei Zhai.;Yock Young Dan.;George Bb Goh.;Mathias F Heikenwälder.;Yongliang Zhang.;Ramanuj Dasgupta.;Wai Meng David Tai.;Haiyan Liu.;Jinmiao Chen.;Valerie Chew.
来源: Gut. 2025年75卷1期105-118页
Steatotic liver disease-related hepatocellular carcinoma (SLD-HCC), a rising global challenge, is characterised by unique tumour microenvironment (TME) adaptations.
316. Hybrid identity and distinct methylation profiles of incomplete intestinal metaplasia in the stomach.
作者: Hyesung Kim.;Junseong Kim.;In Ho Jeong.;Eunsun Park.;Mira Yoo.;Seokho Yoon.;Donghyun Lee.;Jaekyung Myung.;Eunyoung Choi.;James R Goldenring.;Bogun Jang.
来源: Gut. 2025年75卷1期10-23页
Gastric intestinal metaplasia (GIM), particularly the incomplete subtype (Inc IM), is strongly associated with increased gastric cancer (GC) risk. However, its role as a true precursor lesion remains uncertain.
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