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2921. Update Alert: Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 2).
作者: Amir Qaseem.;Jennifer Yost.;Itziar Etxeandia-Ikobaltzeta.;George M Abraham.;Janet A Jokela.;Matthew C Miller.;Mary Ann Forciea.;Linda L Humphrey.; .;Andrew Dunn.;Rebecca Andrews.;Ray Haeme.;Mark P Tschanz.
来源: Ann Intern Med. 2021年174卷9期W66-W67页 2922. Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial.
作者: Andreas Barratt-Due.;Inge Christoffer Olsen.;Katerina Nezvalova-Henriksen.;Trine Kåsine.;Fridtjof Lund-Johansen.;Hedda Hoel.;Aleksander Rygh Holten.;Anders Tveita.;Alexander Mathiessen.;Mette Haugli.;Ragnhild Eiken.;Anders Benjamin Kildal.;Åse Berg.;Asgeir Johannessen.;Lars Heggelund.;Tuva Børresdatter Dahl.;Karoline Hansen Skåra.;Pawel Mielnik.;Lan Ai Kieu Le.;Lars Thoresen.;Gernot Ernst.;Dag Arne Lihaug Hoff.;Hilde Skudal.;Bård Reiakvam Kittang.;Roy Bjørkholt Olsen.;Birgitte Tholin.;Carl Magnus Ystrøm.;Nina Vibeche Skei.;Trung Tran.;Susanne Dudman.;Jan Terje Andersen.;Raisa Hannula.;Olav Dalgard.;Ane-Kristine Finbråten.;Kristian Tonby.;Bjorn Blomberg.;Saad Aballi.;Cathrine Fladeby.;Anne Steffensen.;Fredrik Müller.;Anne Ma Dyrhol-Riise.;Marius Trøseid.;Pål Aukrust.; .
来源: Ann Intern Med. 2021年174卷9期1261-1269页
New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects of these drugs are not known.
2923. Menopause.
This review focuses on the diagnosis and management of menopause, highlighting both hormonal and nonhormonal treatment options. In particular, the article focuses on recent data on the risks and benefits of hormone therapy to help clinicians better counsel their patients about decision making with regard to understanding and treating menopause symptoms.
2926. Web Exclusive. Annals Story Slam - Future I.M. Experience: Resilience During COVID-19.
作者: Carlee Fountaine.;Vivian Kalu.;Naman Upadhyay.;Lexi Frankel.;Victoria Kozar.;Christopher Valentin.;Kristy Abraham.;Amrita Mahesh.;Neha Panchagnula.;Joy Liu.;Zaw Phyo.;Jaclyn Boozalis.
来源: Ann Intern Med. 2021年174卷8期SS1页 2928. In adults and children in the ED with COVID-19 symptoms or a confirmed contact, a rapid POC antigen test had ≥72% sensitivity and ≥99% specificity vs. RT-PCR.
Möckel M, Corman VM, Stegemann MS, et al. SARS-CoV-2 antigen rapid immunoassay for diagnosis of COVID-19 in the emergency department. Biomarkers. 2021;26:213-20. 33455451.
2929. In healthy older adults, daily aspirin increased cancer mortality.
McNeil JJ, Gibbs P, Orchard SG, et al. Effect of aspirin on cancer incidence and mortality in older adults. J Natl Cancer Inst. 2021;113:258-65. 32778876.
2930. The single-dose J&J vaccine had 67% efficacy against moderate to severe-critical COVID-19 at ≥14 d.
Sadoff J, Gray G, Vandebosch A, et al. Safety and efficacy of single-dose Ad26.COV2.S vaccine against Covid-19. N Engl J Med. 2021. [Epub ahead of print.] 33882225.
2932. Colorectal cancer screening offering colonoscopy and FIT vs. colonoscopy alone improved participation.
Pilonis ND, Bugajski M, Wieszczy P, et al. Participation in competing strategies for colorectal cancer screening: a randomized health services study (PICCOLINO study). Gastroenterology. 2021;160:1097-105. 33307024.
2933. In patients with AMI and anemia, a restrictive vs. liberal blood transfusion strategy was noninferior for 30-d MACE.
Ducrocq G, Gonzalez-Juanatey JR, Puymirat E, et al. Effect of a restrictive vs liberal blood transfusion strategy on major cardiovascular events among patients with acute myocardial infarction and anemia: the REALITY randomized clinical trial. JAMA. 2021;325:552-60. 33560322.
2934. In patients having transjugular intrahepatic portosystemic shunt, rifaximin prevented overt hepatic encephalopathy.
Bureau C, Thabut D, Jezequel C, et al. The use of rifaximin in the prevention of overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a randomized controlled trial. Ann Intern Med. 2021;174:633-40. 33524293.
2935. In ANCA-associated vasculitis, avacopan was superior to prednisone taper for sustained remission.
Jayne DRW, Merkel PA, Schall TJ, et al. Avacopan for the treatment of ANCA-associated vasculitis. N Engl J Med. 2021;384:599-609. 33596356.
2936. When COVID-19 Strikes Your Hospital.
Kadri and colleagues presented findings from a nationally representative cohort of 144 116 hospitalized patients cared for in 558 hospitals to understand the effect of COVID-19 surges on patient outcomes. The editorialist discusses the findings and outlines potential strategies to prevent the deleterious effects of future surges on patients and staff.
2938. Mortality Among Persons Entering HIV Care Compared With the General U.S. Population : An Observational Study.
作者: Jessie K Edwards.;Stephen R Cole.;Tiffany L Breger.;Jacqueline E Rudolph.;Lindsey M Filiatreau.;Kate Buchacz.;Elizabeth Humes.;Peter F Rebeiro.;Gypsyamber D'Souza.;M John Gill.;Michael J Silverberg.;W Christopher Mathews.;Michael A Horberg.;Jennifer Thorne.;H Irene Hall.;Amy Justice.;Vincent C Marconi.;Viviane D Lima.;Ronald J Bosch.;Timothy R Sterling.;Keri N Althoff.;Richard D Moore.;Michael Saag.;Joseph J Eron.
来源: Ann Intern Med. 2021年174卷9期1197-1206页
Understanding advances in the care and treatment of adults with HIV as well as remaining gaps requires comparing differences in mortality between persons entering care for HIV and the general population.
2939. Treatment of Acute Pain in Adults With Sickle Cell Disease in an Infusion Center Versus the Emergency Department : A Multicenter Prospective Cohort Study.
作者: Sophie Lanzkron.;Jane Little.;Hang Wang.;Joshua J Field.;J Ryan Shows.;Carlton Haywood.;Mustapha Saheed.;Marc Proudford.;Derek Robertson.;Adrienne Kincaid.;Lorri Burgess.;Charles Green.;Rebecca Seufert.;Jasmine Brooks.;Allie Piehet.;Brandi Griffin.;Nicole Arnold.;Steven Frymark.;Marcus Wallace.;Nebras Abu Al Hamayel.;Chiung-Yu Huang.;Jodi B Segal.;Ravi Varadhan.
来源: Ann Intern Med. 2021年174卷9期1207-1213页
Patients with sickle cell disease (SCD) have vaso-occlusive crises (VOCs). Infusion centers (ICs) are alternatives to emergency department (ED) care and may improve patient outcomes.
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