2841. Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study.
作者: Parakkal Deepak.;Wooseob Kim.;Michael A Paley.;Monica Yang.;Alexander B Carvidi.;Emanuel G Demissie.;Alia A El-Qunni.;Alem Haile.;Katherine Huang.;Baylee Kinnett.;Mariel J Liebeskind.;Zhuoming Liu.;Lily E McMorrow.;Diana Paez.;Niti Pawar.;Dana C Perantie.;Rebecca E Schriefer.;Shannon E Sides.;Mahima Thapa.;Maté Gergely.;Suha Abushamma.;Sewuese Akuse.;Michael Klebert.;Lynne Mitchell.;Darren Nix.;Jonathan Graf.;Kimberly E Taylor.;Salim Chahin.;Matthew A Ciorba.;Patricia Katz.;Mehrdad Matloubian.;Jane A O'Halloran.;Rachel M Presti.;Gregory F Wu.;Sean P J Whelan.;William J Buchser.;Lianne S Gensler.;Mary C Nakamura.;Ali H Ellebedy.;Alfred H J Kim.
来源: Ann Intern Med. 2021年174卷11期1572-1585页
Patients with chronic inflammatory disease (CID) treated with immunosuppressive medications have increased risk for severe COVID-19. Although mRNA-based SARS-CoV-2 vaccination provides protection in immunocompetent persons, immunogenicity in immunosuppressed patients with CID is unclear.
2842. Acute Consumption of Alcohol and Discrete Atrial Fibrillation Events.
作者: Gregory M Marcus.;Eric Vittinghoff.;Isaac R Whitman.;Sean Joyce.;Vivian Yang.;Gregory Nah.;Edward P Gerstenfeld.;Joshua D Moss.;Randall J Lee.;Byron K Lee.;Zian H Tseng.;Vasanth Vedantham.;Jeffrey E Olgin.;Melvin M Scheinman.;Henry Hsia.;Rachel Gladstone.;Shannon Fan.;Emily Lee.;Christina Fang.;Kelsey Ogomori.;Robin Fatch.;Judith A Hahn.
来源: Ann Intern Med. 2021年174卷11期1503-1509页
Patients' self-reports suggest that acute alcohol consumption may trigger a discrete atrial fibrillation (AF) event.
2843. Donor HLA Class 1 Evolutionary Divergence Is a Major Predictor of Liver Allograft Rejection : A Retrospective Cohort Study.
作者: Cyrille Féray.;Jean-Luc Taupin.;Mylène Sebagh.;Vincent Allain.;Zeynep Demir.;Marc-Antoine Allard.;Christophe Desterke.;Audrey Coilly.;Faouzi Saliba.;Eric Vibert.;Daniel Azoulay.;Catherine Guettier.;Arthur Chatton.;Dominique Debray.;Sophie Caillat-Zucman.;Didier Samuel.
来源: Ann Intern Med. 2021年174卷10期1385-1394页
The HLA evolutionary divergence (HED), a continuous metric quantifying the peptidic differences between 2 homologous HLA alleles, reflects the breadth of the immunopeptidome presented to T lymphocytes.
2844. Annual Tuberculosis Preventive Therapy for Persons With HIV Infection : A Randomized Trial.
作者: Gavin Churchyard.;Vicky Cárdenas.;Violet Chihota.;Kathy Mngadi.;Modulakgotla Sebe.;William Brumskine.;Neil Martinson.;Getnet Yimer.;Shu-Hua Wang.;Alberto L Garcia-Basteiro.;Dinis Nguenha.;LeeAnne Masilela.;Zainab Waggie.;Susan van den Hof.;Salome Charalambous.;Frank Cobelens.;Richard E Chaisson.;Alison D Grant.;Katherine L Fielding.; .
来源: Ann Intern Med. 2021年174卷10期1367-1376页
Tuberculosis preventive therapy for persons with HIV infection is effective, but its durability is uncertain.
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