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2663. COVID-19 Vaccination Effectiveness Against Infection or Death in a National U.S. Health Care System : A Target Trial Emulation Study.
作者: George N Ioannou.;Emily R Locke.;Ann M O'Hare.;Amy S B Bohnert.;Edward J Boyko.;Denise M Hynes.;Kristin Berry.
来源: Ann Intern Med. 2022年175卷3期352-361页
Little is known about real-world COVID-19 vaccine effectiveness (VE) in racially and ethnically diverse, elderly populations with high comorbidity burden.
2664. Firearm Purchasing During the COVID-19 Pandemic: Results From the 2021 National Firearms Survey.
The surge in background checks beginning in March 2020 suggested an acceleration in firearm purchases. Little was known about the people who bought these guns.
2665. Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.
作者: .;Jens D Lundgren.;Birgit Grund.;Christina E Barkauskas.;Thomas L Holland.;Robert L Gottlieb.;Uriel Sandkovsky.;Samuel M Brown.;Kirk U Knowlton.;Wesley H Self.;D Clark Files.;Mamta K Jain.;Thomas Benfield.;Michael E Bowdish.;Bradley G Leshnower.;Jason V Baker.;Jens-Ulrik Jensen.;Edward M Gardner.;Adit A Ginde.;Estelle S Harris.;Isik S Johansen.;Norman Markowitz.;Michael A Matthay.;Lars Østergaard.;Christina C Chang.;Anna L Goodman.;Weizhong Chang.;Robin L Dewar.;Norman P Gerry.;Elizabeth S Higgs.;Helene Highbarger.;Daniel D Murray.;Thomas A Murray.;Ven Natarajan.;Roger Paredes.;Mahesh K B Parmar.;Andrew N Phillips.;Cavan Reilly.;Adam W Rupert.;Shweta Sharma.;Kathryn Shaw-Saliba.;Brad T Sherman.;Marc Teitelbaum.;Deborah Wentworth.;Huyen Cao.;Paul Klekotka.;Abdel G Babiker.;Victoria J Davey.;Annetine C Gelijns.;Virginia L Kan.;Mark N Polizzotto.;B Taylor Thompson.;H Clifford Lane.;James D Neaton.
来源: Ann Intern Med. 2022年175卷2期234-243页
In a randomized, placebo-controlled, clinical trial, bamlanivimab, a SARS-CoV-2-neutralizing monoclonal antibody, given in combination with remdesivir, did not improve outcomes among hospitalized patients with COVID-19 based on an early futility assessment.
2669. Smoking Cessation.
作者: Manish S Patel.;Sheetal B Patel.;Michael B Steinberg.
来源: Ann Intern Med. 2021年174卷12期ITC177-ITC192页
Tobacco smoking is the leading cause of preventable death in the United States, and its harms are well established. Physicians have more evidence-based resources than ever before to effectively treat smoking, including new uses and combinations of U.S. Food and Drug Administration-approved pharmacotherapies and expanded community programs. In addition, electronic nicotine delivery systems are potential treatment tools, but their safety and efficacy need to be established. Finally, high-priority groups, such as persons with cancer diagnoses or hospitalized patients, may benefit from particular attention to their tobacco use.
2671. How Would You Treat This Patient Hospitalized With Community-Acquired Pneumonia? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
作者: Zahir Kanjee.;Joshua P Metlay.;Ari Moskowitz.;Eileen E Reynolds.
来源: Ann Intern Med. 2021年174卷12期1719-1726页
Community-acquired pneumonia is a major cause of morbidity and mortality in the United States, leading to 1.5 million hospitalizations and at least 200 000 deaths annually. The 2019 American Thoracic Society/Infectious Diseases Society of America clinical practice guideline on diagnosis and treatment of adults with community-acquired pneumonia provides an evidence-based overview of this common illness. Here, 2 experts, a general internist who served as the co-primary author of the guidelines and a pulmonary and critical care physician, debate the management of a patient hospitalized with community-acquired pneumonia. They discuss disease severity stratification methods, whether to use adjunctive corticosteroids, and when to prescribe empirical treatment for multidrug-resistant organisms such as methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
2673. Update Alert 3: Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19.
作者: Giovanna Elsa Ute Muti-Schüenemann.;Wojciech Szczeklik.;Karla Solo.;Joanne Khabsa.;Rebecca Thomas.;Ewa Borowiack.;Assem M Khamis.;Layal Hneiny.;Andrea Darzi.;Leila Harrison.;Anna Bak.;Antonio Bongnanni.;Gian Paolo Morgano.;Rosa Stalteri.;Anisa Hajizadeh.;Tamara Lotfi.;Marge Reinap.;Bram Rochwerg.;Elie A Akl.;Holger J Schünemann.
来源: Ann Intern Med. 2022年175卷1期W6-W7页 2674. Safety and Efficiency of Diagnostic Strategies for Ruling Out Pulmonary Embolism in Clinically Relevant Patient Subgroups : A Systematic Review and Individual-Patient Data Meta-analysis.
作者: Milou A M Stals.;Toshihiko Takada.;Noémie Kraaijpoel.;Nick van Es.;Harry R Büller.;D Mark Courtney.;Yonathan Freund.;Javier Galipienzo.;Grégoire Le Gal.;Waleed Ghanima.;Menno V Huisman.;Jeffrey A Kline.;Karel G M Moons.;Sameer Parpia.;Arnaud Perrier.;Marc Righini.;Helia Robert-Ebadi.;Pierre-Marie Roy.;Maarten van Smeden.;Phil S Wells.;Kerstin de Wit.;Geert-Jan Geersing.;Frederikus A Klok.
来源: Ann Intern Med. 2022年175卷2期244-255页
How diagnostic strategies for suspected pulmonary embolism (PE) perform in relevant patient subgroups defined by sex, age, cancer, and previous venous thromboembolism (VTE) is unknown.
2675. SARS-CoV-2 Vaccine Antibody Response and Breakthrough Infection in Patients Receiving Dialysis.
作者: Shuchi Anand.;Maria E Montez-Rath.;Jialin Han.;Pablo Garcia.;LinaCel Cadden.;Patti Hunsader.;Curt Morgan.;Russell Kerschmann.;Paul Beyer.;Mary Dittrich.;Geoffrey A Block.;Glenn M Chertow.;Julie Parsonnet.
来源: Ann Intern Med. 2022年175卷3期371-378页
Whether breakthrough SARS-CoV-2 infections after vaccination are related to the level of postvaccine circulating antibody is unclear.
2676. In suspected ACS, an unmasked 0/1-h vs. masked 0/3-h hs-cTnT protocol did not differ for death or MI at 1 y.
Lambrakis K, Papendick C, French JK, et al. Late outcomes of the RAPID-TnT randomized controlled trial: 0/1-hour high-sensitivity troponin T protocol in suspected ACS. Circulation. 2021;144:113-25. 33998255.
2677. In ACS, de-escalation of DAPT reduces bleeding and does not increase ischemic events vs. other DAPT strategies.
Shoji S, Kuno T, Fujisaki T, et al. De-escalation of dual antiplatelet therapy in patients with acute coronary syndromes. J Am Coll Cardiol. 2021;78:763-77. 34275697.
2680. Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study.
作者: Rahul D Pawar.;Lakshman Balaji.;Anne V Grossestreuer.;Garrett Thompson.;Mathias J Holmberg.;Mahmoud S Issa.;Parth V Patel.;Ryan Kronen.;Katherine M Berg.;Ari Moskowitz.;Michael W Donnino.
来源: Ann Intern Med. 2022年175卷2期191-197页
Thiamine supplementation is recommended for patients with alcohol use disorder (AUD). The authors hypothesize that critically ill patients with AUD are commonly not given thiamine supplementation.
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