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2461. After DES implantation, DAPT for 1 y vs. ≤6 mo increased major bleeding in patients with high baseline bleeding risk.
Palmerini T, Bruno AG, Redfors B, et al. Risk-benefit of 1-year DAPT after DES implantation in patients stratified by bleeding and ischemic risk. J Am Coll Cardiol. 2021;78:1968-86. 34763774.
2462. PICC vs. midline catheter use for short-term indications was linked to major complications at ≤30 d.
Swaminathan L, Flanders S, Horowitz J, et al. Safety and outcomes of midline catheters vs peripherally inserted central catheters for patients with short-term indications: a multicenter study. JAMA Intern Med. 2022;182:50-8. 34842905.
2463. In osteoporosis or osteopenia, exercise interventions improve BMD; effects vary by exercise type and BMD site.
Zhang S, Huang X, Zhao X, et al. Effect of exercise on bone mineral density among patients with osteoporosis and osteopenia: a systematic review and network meta-analysis. J Clin Nurs. 2021. [Epub ahead of print]. 34725872.
2464. In nonhospitalized, unvaccinated adults with COVID-19, molnupiravir reduced hospitalization or death at 29 d.
Jayk Bernal A, Gomes da Silva MM, Musungaie DB, et al. Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients. N Engl J Med. 2022;386:509-20. 34914868.
2465. In acute ischemic stroke, EVT alone vs. IV alteplase plus EVT did not differ for functional outcome at 90 d.
LeCouffe NE, Kappelhof M, Treurniet KM, et al. A randomized trial of intravenous alteplase before endovascular treatment for stroke. N Engl J Med. 2021;385:1833-44. 34758251.
2466. In inpatients with COVID-19 who need supplemental oxygen, lenzilumab increased ventilation-free survival.
Temesgen Z, Burger CD, Baker J, et al. Lenzilumab in hospitalised patients with COVID-19 pneumonia (LIVE-AIR): a phase 3, randomised, placebo-controlled trial. Lancet Respir Med. 2022;10:237-46. 34863332.
2467. Antihypertensive drugs reduced risk for new-onset type 2 diabetes; effect varies by antihypertensive class.
Nazarzadeh M, Bidel Z, Canoy D, et al. Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis. Lancet. 2021;398:1803-10. 34774144.
2468. Homicide Deaths Among Adult Cohabitants of Handgun Owners in California, 2004 to 2016 : A Cohort Study.
作者: David M Studdert.;Yifan Zhang.;Erin E Holsinger.;Lea Prince.;Alexander F Holsinger.;Jonathan A Rodden.;Garen J Wintemute.;Matthew Miller.
来源: Ann Intern Med. 2022年175卷6期804-811页
Although personal protection is a major motivation for purchasing firearms, existing studies suggest that people living in homes with firearms have higher risks for dying by homicide. Distribution of those risks among household members is poorly understood.
2470. Changes in Health Care Spending, Use, and Clinical Outcomes After Nonfatal Firearm Injuries Among Survivors and Family Members : A Cohort Study.
作者: Zirui Song.;José R Zubizarreta.;Mia Giuriato.;Erica Paulos.;Katherine A Koh.
来源: Ann Intern Med. 2022年175卷6期795-803页
Despite increasing awareness of firearm-related deaths, evidence on the clinical and economic implications of nonfatal firearm injuries is limited.
2474. Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring : A Nationwide Cohort Study.
作者: Maarten J Wensink.;Ying Lu.;Lu Tian.;Gary M Shaw.;Silvia Rizzi.;Tina Kold Jensen.;Elisabeth R Mathiesen.;Niels E Skakkebæk.;Rune Lindahl-Jacobsen.;Michael L Eisenberg.
来源: Ann Intern Med. 2022年175卷5期665-673页
Diabetes reduces semen quality and increasingly occurs during reproductive years. Diabetes medications, such as metformin, have glucose-independent effects on the male reproductive system. Associations with birth defects in offspring are unknown.
2475. Effectiveness of Motivational Interviewing in Managing Overweight and Obesity : A Systematic Review and Meta-analysis.
作者: Moscho Michalopoulou.;Anne E Ferrey.;Georgina Harmer.;Lucy Goddard.;Maryam Kebbe.;Annika Theodoulou.;Susan A Jebb.;Paul Aveyard.
来源: Ann Intern Med. 2022年175卷6期838-850页
Motivational interviewing (MI) is potentially useful in management of overweight and obesity, but staff training and increased delivery time are barriers, and its effectiveness independent of other behavioral components is unclear.
2476. Risks for Anaphylaxis With Intravenous Iron Formulations : A Retrospective Cohort Study.
作者: Chintan V Dave.;Gary M Brittenham.;Jeffrey L Carson.;Soko Setoguchi.
来源: Ann Intern Med. 2022年175卷5期656-664页
The risks for anaphylaxis among intravenous (IV) iron products currently in use have not been assessed.
2480. Implementation of a SARS-CoV-2 Genotyping Panel for Prompt Omicron Variant Identification: A Pragmatic Tool for Clinical Laboratories.
作者: Eliezer Zachary Nussbaum.;Vamsi Thiriveedhi.;Rockib Uddin.;Ha Eun Cho.;Seamus Carroll.;Eric S Rosenberg.;Jacob E Lemieux.;Sarah E Turbett.
来源: Ann Intern Med. 2022年175卷6期906-908页 |