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221. Targeting PPAR-γ Reduces Fibrosis and Arrhythmogenic Remodeling in DSG2-Linked Arrhythmogenic Cardiomyopathy.
作者: Yung-Hsin Yeh.;Yu-Shien Ko.;Yi-Hsin Chan.;Ying-Ju Lai.;Gwo-Jyh Chang.;Chi-Jen Chang.;Lung-An Hsu.
来源: Circ Genom Precis Med. 2026年e005434页
Arrhythmogenic cardiomyopathy is an inherited disorder characterized by fibro-fatty myocardial replacement and ventricular arrhythmias. Although desmosomal mutations such as desmoglein-2 (DSG2) are well-established causes, the pathogenic mechanisms of specific missense variants remain incompletely defined.
223. Yield of Postmortem Genetic Testing in Sudden Arrhythmic Death Syndrome: A Systematic Review and Meta-Analysis.
作者: Emanuele Monda.;Sabrina Montuoro.;Lia Crotti.;Cristina Basso.;Martina Caiazza.;Emanuele Bobbio.;Camillo Autore.;Elena Arbelo.;Gaetano Diana.;Perry Mark Elliott.;Eloisa Arbustini.;Giuseppe Limongelli.
来源: Circ Genom Precis Med. 2026年e005523页
Sudden arrhythmic death syndrome (SADS) refers to sudden cardiac death with structurally normal hearts at autopsy, most frequently attributed to inherited arrhythmia syndromes or concealed cardiomyopathies. Postmortem genetic testing may help identify underlying genetic causes. We aimed to investigate the yield of postmortem genetic testing in SADS cases by determining the prevalence of pathogenic or likely pathogenic variants in channelopathy- and cardiomyopathy-associated genes in autopsy-negative SADS victims.
224. FGF12 Alleviates Cardiac Hypertrophy by Inhibiting Phosphorylation of CaM/CaMKII/CREB1 Axis.
作者: Taojun Zhang.;Kunlun Yin.;Tianjiao Li.;Shuiyun Wang.;Zhou Zhou.
来源: Circ Genom Precis Med. 2026年e005362页
Hypertrophic cardiomyopathy (HCM) arises from genetic mutations in sarcomere proteins, resulting in major structural abnormalities and limited treatment options. Patients with HCM had reduced expression of the FGF12 (fibroblast growth factor 12), but its precise functional role remains unclear.
225. RACGAP1 as a Circulating Biomarker of Atrial Fibrillation in Heart Failure: A Dual-Cohort Proteomic Study.
作者: Amen Bekele Zelleke.;Joe David Azzo.;Jonathan D Moreno.;Douglas L Mann.;Thomas P Cappola.;Julio A Chirinos.;Ali Javaheri.
来源: Circ Arrhythm Electrophysiol. 2026年19卷5期e014024页 226. Automated Cardiac Arrest Detection Using Wrist-Worn Photoplethysmography: External Validation in Patients With Induced Shockable Cardiac Arrest (DETECT-1b).
作者: Roos Edgar.;Niels T B Scholte.;Kambiz Ebrahimkheil.;Catharina E Jansen.;Rypko J Beukema.;Marc A Brouwer.;Sing-Chien Yap.;Masih Mafi-Rad.;Reinoud E Knops.;Eelko Ronner.;Aysun Cetinyurek-Yavuz.;Kevin Vernooy.;Eric Boersma.;Peter C Stas.;Niels van Royen.;Judith L Bonnes.
来源: Circ Arrhythm Electrophysiol. 2026年19卷5期e014708页 227. Interventional MRI-Guided Ablation of Left Ventricular Tachycardia.
作者: Luuk H G A Hopman.;Marco J W Götte.;Jules L Nelissen.;Raschel D F van Luijk.;Marjolein F Koster.;Mika J Sybrandi.;Katherine Lindborg.;Pieter G Postema.;Steven A J Chamuleau.;Cornelis P Allaart.;Michiel J B Kemme.
来源: Circulation. 2026年 228. Correction to: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
作者: Daniel W Jones.;Keith C Ferdinand.;Sandra J Taler.;Heather M Johnson.;Daichi Shimbo.;Marwah Abdalla.;M Martine Altieri.;Nisha Bansal.;Natalie A Bello.;Adam P Bress.;Jocelyn Carter.;Jordana B Cohen.;Karen J Collins.;Yvonne Commodore-Mensah.;Leslie L Davis.;Brent Egan.;Sadiya S Khan.;Donald M Lloyd-Jones.;Bernadette Mazurek Melnyk.;Eva A Mistry.;Modele O Ogunniyi.;Stacey L Schott.;Sidney C Smith.;Amy W Talbot.;Wanpen Vongpatanasin.;Karol E Watson.;Paul K Whelton.;Jeff D Williamson.
来源: Circulation. 2026年153卷15期e1121页 229. Dysregulated Aldosterone Production in Obesity Is Associated With Adverse Cardiac Structure, Function, and Adiposity.
作者: Cheng-Hsuan Tsai.;Justin M Chan.;Julia Milks.;Arnaldo Ferrebus.;Isabelle Hanna.;Sanan Mahrokhian.;Andrew J Newman.;Stéfanie Parisien-La Salle.;Isabela Reis Marques.;Kristen Foote.;Gail K Adler.;Raymond Y Kwong.;Michael Jerosch-Herold.;Bertram Pitt.;Anand Vaidya.;Jenifer M Brown.
来源: Circulation. 2026年153卷15期1174-1177页 231. Letter by Zhuang et al Regarding Article, "Experiences of Stalking and Obtaining a Restraining Order Are Associated With Onset of Cardiovascular Events in Women: A Prospective Analysis in the Nurses' Health Study II".233. Response by Murchland et al to Letter Regarding Article, "Experiences of Stalking and Obtaining a Restraining Order Are Associated With Onset of Cardiovascular Events in Women: A Prospective Analysis in the Nurses' Health Study II".
作者: Audrey R Murchland.;Karestan C Koenen.;Rebecca B Lawn.
来源: Circulation. 2026年153卷15期e1119-e1120页 235. Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics.
作者: Lei Wang.;Maximilian Staps.;Stefan Günther.;Elie El Agha.;Saverio Bellusci.;Carsten Kuenne.;Junhua Du.;Andre Schneider.;Thomas Braun.
来源: Circulation. 2026年
The Cre/loxP recombination system is the main tool for cell type-specific lineage tracing and gene targeting. Currently available smooth muscle cell (SMC)-specific Cre mouse lines show off-target activity outside the SMC lineage and are unable to distinguish among arterial SMCs (ASMCs), venous SMCs, and nonvascular SMCs (NVSMCs). These limitations prevent ASMC- and NVSMC-specific gene targeting, which is required to characterize the role of SMCs in different organs and diseases.
236. Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis.
作者: Jan-Christian Reil.;Vasco Sequeira.;Cédric Coppée.;Karina Peters.;Jan M Federspiel.;Paul Steendijk.;Christoph Maack.;Mark T Waddingham.;Volker Rudolph.;Gert-Hinrich Reil.;Smita Scholtz.
来源: Circ Heart Fail. 2026年19卷5期e013392页
Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by left ventricular (LV) outflow tract obstruction, which increases afterload and chronically activates the Anrep response, a compensatory (afterload-driven) state of hyperdynamic systole, prolonged systolic ejection time, and increased myocardial workload. We investigated whether the myosin inhibitor mavacamten reverses this state, comparing its effects to the anatomic relief achieved by alcohol septal ablation.
237. Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis.
作者: Zachary A Patel.;Meg K Ospina.;Roxanne Mittelstaedt.;Jacob Peller.;Stephanie Samani.;Charlotte Marchell.;Kelly Ohlrich.;Brady Gunn.;Michael Varrone.;Kaylen Dodson.;Lindsey Bull.;Hajj Jennifer.;Mathew J Gregoski.;Molly Silkowski.;Michele Esposito.;Ryan J Tedford.;Jeffrey D McMurray.;Lucas Witer.;Arman Kilic.;Brian A Houston.;Anthony P Carnicelli.
来源: Circ Heart Fail. 2026年e013742页
Temporary mechanical support (tMCS) devices are often placed for cardiogenic shock (CS) at regional referral centers (RRCs) before transfer to CS hub centers (HCs). We sought to assess for differences in device-related adverse events (DRAEs) and outcomes between patients with tMCS placement for CS at an RRC before transfer to an HC compared with initial tMCS device placement at an HC.
238. Female Sex-Related Stroke Risk in Atrial Fibrillation: A Thing From the Past?
作者: Konsta Teppo.;K E Juhani Airaksinen.;Jari Haukka.;Ville L Langén.;Olli Halminen.;Jukka Putaala.;Miika Linna.;Pirjo Mustonen.;Juha Hartikainen.;Gregory Y H Lip.;Mika Lehto.
来源: Circ Arrhythm Electrophysiol. 2026年19卷4期e014728页 239. Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging.
作者: Brett W Sperry.;Evan O'Keefe.;Eric V Burgett.;Erika Hutt.;Philip G Jones.;James A Case.;Timothy M Bateman.
来源: Circ Cardiovasc Imaging. 2026年19卷5期e019371页
Technetium-labeled bone-avid tracers have been repurposed to diagnose transthyretin cardiac amyloidosis without rigorous kinetic studies. Supply shortages have necessitated the use of hydroxymethylene diphosphonate (HMDP) as an alternative to technetium-99m pyrophosphate, though comparative data remain limited. This study characterizes tracer kinetics using quantitative single-photon emission computed tomography with computed tomography.
240. Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank.
作者: Jianfeng Xu.;Zhuqing Shi.;Sumeet A Khetarpal.;Ashley J Mulford.;Osama Siddiqui.;Huy Tran.;Jun Wei.;Annabelle Ashworth.;S Lilly Zheng.;David Duggan.;Brian T Helfand.;Henry M Dunnenberger.;Peter J Hulick.;David J Davidson.;Amit V Khera.;Aniruddh P Patel.;Alan R Sanders.;Arman Qamar.
来源: Circ Genom Precis Med. 2026年e005494页
Current genetic testing for coronary artery disease (CAD) primarily targets monogenic variants in individuals with severe hypercholesterolemia. Whether supplementing monogenic testing with polygenic risk scores for CAD and Lp(a; lipoprotein[a]) levels [PRSLp(a)] improves identification of high-risk individuals in the general population remains understudied.
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