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201. Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis.
作者: Mohamed G Shiha.;Francesca Manza.;Oscar G Figueroa-Salcido.;Noé Ontiveros.;Giacomo Caio.;Claire L Jansson-Knodell.;Alberto Rubio-Tapia.;Imran Aziz.;David S Sanders.
来源: Gut. 2025年
Non-coeliac gluten/wheat sensitivity (NCGWS) is characterised by gastrointestinal and extraintestinal symptoms related to gluten or wheat ingestion in individuals without coeliac disease or wheat allergy.
202. Profiles of quantitative hepatitis B surface antigen in patients with chronic hepatitis B.
作者: Jian Wang.;Tao Fan.;Li Zhu.;Shaoqiu Zhang.;Ye Xiong.;Chao Jiang.;Juan Xia.;Renling Yao.;Xiaomin Yan.;Xingxiang Liu.;Chuanwu Zhu.;Chao Wu.;Rui Huang.
来源: Gut. 2025年 203. Characteristics of an antibody profile associated with protection against hepatitis C virus reinfection in a high-risk cohort.
作者: Ana Luz Chumbe.;Suzanne M D van den Aardweg.;Anders Boyd.;Marloes Grobben.;Sylvie M Koekkoek.;Ian Zon.;Maria Prins.;Kwinten Sliepen.;Marit J van Gils.;Janke Schinkel.
来源: Gut. 2025年
Without a vaccine, HCV (re)infections continue to afflict individuals at high risk, for example, men who have sex with men (MSM).
204. First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia.
作者: Sandeep Grover.;Ines Gockel.;Anna Latiano.;Anna Mokrowiecka.;Pouria Dasmeh.;Mira M Wouters.;Zuzana Vackova.;Stephan L Haas.;Tania Triantafyllou.;Nicole Kreuser.;Jessica Trautmann.;Stefan Niebisch.;Timo Hess.;Rene Thieme.;Jessica Bigge.;Hubert Louis.;Eric Quertinmont.;Aline Meirhaeghe.;Manon Muntaner.;Philippe Amouyel.;Guillaume Gourcerol.;Stanislas Bruley des Varannes.;Francois Mion.;Michael Vieth.;Nikolaos Scarmeas.;Orazio Palmieri.;Francesca Tavano.;Roberto De Giorgio.;Daniela Galimberti.;Andrea Arighi.;Beatrice Arosio.;Marco Bruno.;Justyna Wasielica-Berger.;Magdalena Gawron-Kiszka.;Maria Janiak.;Magdalena Siepsiak.;Krystian Adrych.;Tomasz Marek.;Andrzej Dabrowski.;Marek Majewski.;Piotr Gietka.;Maciej Gonciarz.;Julio Pérez de la Serna.;Laisy Zacarías Martínez.;Vilmantas Giedraitis.;Lena Kilander.;Laura Fratiglioni.;Luis Miguel Real.;Julius Spicak.;Jan Tack.;Stefanie Heilmann-Heimbach.;Markus Nöthen.;Martin Ingelsson.;Caroline Graff.;Agustín Ruiz.;Jean-Charles Lambert.;Alfredo Ramirez.;Alexander J Eckardt.;Michaela Müller.;Michael Knapp.;Thaddäus T Wissinowski.;Jutta Keller.;Christiane Josephine Bruns.;Christian Gerges.;Horst Neuhaus.;Thomas Rösch.;Britta Siegmund.;Brigitte Schumacher.;Marino Venerito.;Antonio Ruiz de León.;Riccardo Rosati.;Vito Annese.;Uberto Fumagalli.;Luigi Laghi.;Elena Urcelay.;Fabienne Vavasseur.;Sabine Roman.;Pinghong Zhou.;Quanlin Li.;Zuqiang Liu.;Burkhard H A von Rahden.;Dimitris Theodorou.;Ewa Malecka-Wojciesko.;Carlo Maj.;Ana G Vigo.;Jan Martinek.;Guy Boeckxstaens.;Johannes Schumacher.
来源: Gut. 2025年75卷3期
Idiopathic achalasia (IA) is characterised by the degeneration of neurons in the myenteric plexus leading to an irreversible impaired oesophageal function. Although immune-mediated mechanisms have been proposed, the underlying aetiopathology of IA remains poorly understood.
205. SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL.
作者: Mi Zhang.;Chanyuan Chen.;Haifeng Zhang.;Tanqing Long.;Tingjie Wang.;Nanjin Ding.;Ruitao Long.;Hua Wu.;Zhilu Ma.;Zhongyu Cheng.;Junyan Tao.;Dong Kuang.;Lei Li.;Chuanrui Xu.
来源: Gut. 2025年
SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear.
208. iPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation.
作者: Fan Liu.;Tianxu Liu.;Xi Wu.;Zihao Yu.;Jincheng Tong.;Lili Wang.;Chenyan Zhao.;Jianhui Nie.;Youchun Wang.;Kai Wang.;Lin Bai.;Pengyan Xia.;Kai Wang.;Guochao Wei.;Zi-Zheng Zheng.;Di Wu.;Weijin Huang.;Lin Wang.
来源: Gut. 2026年75卷4期787-800页
Hepatitis E virus (HEV), the leading global cause of acute viral hepatitis, lacks robust in vitro models for virology and pathogenesis research.
210. PDE5A+ cancer-associated fibroblasts enhance immune suppression in gastric cancer.
作者: Kewei Wang.;Chen-Jun Xie.;Zheng Ding.;Ting Shan.;Zhangfeng Zhong.;Feng-Lai Yuan.;Jun-Jie Wu.;Zheng-Dong Yuan.;Chengjia Qian.;Lihua Yu.;Yankui Liu.;Jianqing Cheng.;Qing-Lin Zhang.;Wei Liu.;Yong Zhao.;Jianfeng Huang.;Wen-Zhe Zhang.;Qian Yin.;Bo-Yu Gao.;Jie-Qing Hou.;Ji-Chao Wang.;Jie Mei.;Chao Deng.
来源: Gut. 2025年
Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) in GC.
211. SMYD2-mediated methylation of STAT1 protects against hepatic ischaemia/reperfusion injury by blocking JAK-STAT1 signalling pathways.
作者: Zhiyong Yang.;Yufeng Hu.;Chunyong Yang.;Yujie Li.;Xueyuan Zhong.;Zhenfu Wu.;Yingjie Zuo.;Shanyu Gan.;Lin Chen.;Ziyang Zeng.;Guiheng Qi.;Yuanbao Chen.;Junjie Zhou.;Xiao-Jing Zhang.;Hongliang Li.;Bin Yi.
来源: Gut. 2026年75卷2期326-340页
The JAK/STAT pathway plays a pivotal role in hepatic ischaemia/reperfusion (I/R) injury, a serious perioperative complication. Although signal transducers and activators of transcription 1 (STAT1) activation is known to drive I/R-induced injury, the specific post-translational modifications (PTMs) governing its activity in hepatic I/R remain poorly understood.
213. Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts.
作者: Zhenyu Huo.;Yijun Chen.;Yating Huang.;Zhirong Yang.;Yujun Long.;Qian Zhang.;Shuohua Chen.;Guodong Wang.;Shengtao Zhu.;Dianjianyi Sun.;Canqing Yu.;Jun Lv.;Liming Li.;Ming-Hua Zheng.;Shouling Wu.;Yuanjie Pang.;Shanshan Wu.
来源: Gut. 2026年75卷4期772-785页
Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) are at increased risk of both hepatic and extrahepatic adverse outcomes. However, the evidence regarding lean MASLD and its prognosis remains controversial.
214. Response to: 'Lumen-apposing metal stents for pancreatic fluid collections: has advancing technology encouraged overreach?' by Besim Fazil et al.
作者: Tsuyoshi Hamada.;Tomotaka Saito.;Nobuaki Michihata.;Hideo Yasunaga.;Yousuke Nakai.; .; .
来源: Gut. 2025年 215. KIF1Bβ suppresses hepatocellular carcinoma by transporting and secreting FBLN5 to attenuate the integrin pathway.
作者: Chengming Gao.;Yahui Wang.;Guangming Zhou.;Peipei Shi.;Ji-Ao Wang.;Junjie Wu.;Song Liao.;Han Yan.;Yifei Qiu.;Hongbo Yan.;Tao Zeng.;Ruofan Li.;Ying Zhang.;Pengbo Cao.;Chenning Yang.;Jiazhou Ye.;Rong Liang.;Yuting Wang.;Furong Cheng.;Kaina Hao.;Jinwen Zhang.;Xiaoyu Hu.;Rui Guo.;Qiming Wang.;Fuchu He.;Yuanfeng Li.;Gangqiao Zhou.
来源: Gut. 2026年75卷5期1030-1042页
Our previous genome-wide association study (GWAS) identified that chromosome 1p36.22 locus contributes to the risk of hepatocellular carcinoma (HCC).
217. Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data.
作者: Veronique Van der Voort.;Marion Schaefer.;Timothee Wallenhorst.;Vincent Lepilliez.;Thibault Degand.;Yann Le Baleur.;Philippe Leclercq.;Arthur Berger.;Edouard Chabrun.;Bertrand Brieau.;Maximilien Barret.;Gabriel Rahmi.;Romain Legros.;Jérôme Rivory.;Sarah Leblanc.;Geoffroy Vanbiervliet.;Ludovico Alfarone.;Julien Magne.;Jean-Baptiste Zeevaert.;Jérémie Albouys.;Guillaume Perrod.;Clara Yzet.;Hugo Lepetit.;Arthur Belle.;Stanislas Chaussade.;Florian Rostain.;Martin Dahan.;Alexandru Lupu.;Jean-Baptiste Chevaux.;Mathieu Pioche.;Jérémie Jacques.; .
来源: Gut. 2025年
For large non-pedunculated rectal polyps, en bloc resection via endoscopic submucosal dissection (ESD) is typically recommended due to presumed higher risk of submucosal invasive cancer (SMIC) compared with the colon; however, data on cancer risk by location remain controversial.
219. Crosstalk between liver sinusoidal endothelial cells and hepatocytes via IL-1α-IL1R1 axis exacerbates ischaemia/reperfusion injury in aged livers.
作者: Yasong Liu.;Tingting Wang.;Feng Zhang.;Xuying Liu.;Zhongying Hu.;Jiebin Zhang.;Haitian Chen.;Jiaqi Xiao.;Qiang You.;Zhengqi Wu.;Jia Yao.;Yingcai Zhang.;Shuhong Yi.;Hua Li.;Qi Zhang.;Yang Yang.;Rong Li.;Jun Zheng.
来源: Gut. 2025年
With population ageing, elderly patients account for a growing proportion of hepatic surgery recipients. Hepatic ischaemia-reperfusion injury (HIRI) is a major cause of postoperative liver dysfunction, particularly in aged livers, yet its mechanisms remain poorly understood.
220. Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma.
作者: Jun Zhong.;Aidan O'Brien.;Minal B Patel.;Daina Eiser.;Michael Mobaraki.;Irene Collins.;Li Wang.;Konnie Guo.;ThucNhi TruongVo.;Ashley Jermusyk.;Sudipto Das.;Maura O'Neill.;Courtney D Dill.;Andrew D Wells.;Michelle E Leonard.;James A Pippin.;Struan F A Grant.;Tongwu Zhang.;Thorkell Andresson.;Katelyn E Connelly.;Jianxin Shi.;H Efsun Arda.;Jason W Hoskins.;Laufey T Amundadottir.
来源: Gut. 2025年
The identification and characterisation of somatic cancer driver mutations in the non-coding genome remains challenging.
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