2112. Monoclonal Antibodies for Treatment of SARS-CoV-2 Infection During Pregnancy : A Cohort Study.
作者: Erin K McCreary.;Lara Lemon.;Christina Megli.;Amber Oakes.;Christopher W Seymour.; .
来源: Ann Intern Med. 2022年175卷12期1707-1715页
Monoclonal antibody (mAb) treatment decreases hospitalization and death in high-risk outpatients with mild to moderate COVID-19. However, no studies have evaluated adverse events and effectiveness of mAbs in pregnant persons compared with no mAb treatment.
2115. Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis: A Randomized Controlled Trial.
作者: Andrew J Goldberg.;Kashfia Chowdhury.;Ekaterina Bordea.;Iva Hauptmannova.;James Blackstone.;Deirdre Brooking.;Elizabeth L Deane.;Stephen Bendall.;Andrew Bing.;Chris Blundell.;Sunil Dhar.;Andrew Molloy.;Steve Milner.;Mike Karski.;Steve Hepple.;Malik Siddique.;David T Loveday.;Viren Mishra.;Paul Cooke.;Paul Halliwell.;David Townshend.;Simon S Skene.;Caroline J Doré.; .;Rick Brown.;Michael Butler.;Carolyn Chadwick.;Tim Clough.;Nick Cullen.;Mark Davies.;Howard Davies.;Bill Harries.;Michael Khoo.;Nilesh Makwana.;An Murty.;Ali Najefi.;Paul O'Donnell.;Martin Raglan.;Rhys Thomas.;Paulo Torres.;Matthew Welck.;Ian Winson.;Razi Zaidi.
来源: Ann Intern Med. 2022年175卷12期1648-1657页
End-stage ankle osteoarthritis causes severe pain and disability. There are no randomized trials comparing the 2 main surgical treatments: total ankle replacement (TAR) and ankle fusion (AF).
2119. Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial.
作者: Michael Camilleri.;Thyagarajan Subramanian.;Fernando Pagan.;Stuart Isaacson.;Ramon Gil.;Robert A Hauser.;Mary Feldman.;Mark Goldstein.;Rajeev Kumar.;Daniel Truong.;Nisha Chhabria.;Benjamin L Walter.;Jonathan Eskenazi.;Robert Riesenberg.;Daniel Burdick.;Winona Tse.;Eric Molho.;Bradley Robottom.;Perminder Bhatia.;Srinath Kadimi.;Kevin Klos.;David Shprecher.;Otto Marquez-Mendoza.;Gonzalo Hidalgo.;Stephen Grill.;George Li.;Howard Mandell.;Mary Hughes.;Sharisse Stephenson.;Joel Vandersluis.;Michael Pfeffer.;Andrew Duker.;Vikram Shivkumar.;William Kinney.;James MacDougall.;Michael Zasloff.;Denise Barbut.
来源: Ann Intern Med. 2022年175卷12期1666-1674页
Parkinson disease (PD) is associated with α-synuclein (αS) aggregation within enteric neurons. ENT-01 inhibits the formation of αS aggregates and improved constipation in an open-label study in patients with PD.
2120. Contact Tracing and Exposure Investigation in Response to the First Case of Monkeypox Virus Infection in the United States During the 2022 Global Monkeypox Outbreak.
作者: Erica S Shenoy.;Sharon B Wright.;Deborah N Barbeau.;Lisa A Foster.;Aleah D King.;Patrick S Gordon.;Preeti Mehrotra.;Dana E Pepe.;Daniel A Caroff.;Lindsey R Kim.;Shannon E McGrath.;Amy Courtney.;Meredith Fahy.;David C Hooper.;Kaitlin Macdonald.;Eileen F Searle.;Jennifer A Shearer.;Kimon C Zachary.;Lindsay Bouton.;Melissa Cumming.;Brandi Hopkins.;Juliana Jacoboski.;Erin Mann.;Matthew Osborne.;Carley Perez.;Jordan Schultz.;Sarah Scotland.;Elizabeth Traphagen.;Lawrence C Madoff.;Catherine M Brown.
来源: Ann Intern Med. 2022年175卷12期1639-1647页
In May 2022, the first case of monkeypox virus (MPXV) infection in the United States in the current global outbreak was identified. As part of the public health and health care facility response, a contact tracing and exposure investigation was done.
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