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2081. HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer.
作者: Chang Xu.;Wen Fong Ooi.;Aditi Qamra.;Jing Tan.;Benjamin Yan-Jiang Chua.;Shamaine Wei Ting Ho.;Kakoli Das.;Zul Fazreen Adam Isa.;Zhimei Li.;Xiaosai Yao.;Tingdong Yan.;Manjie Xing.;Kie Kyon Huang.;Joyce Suling Lin.;Tannistha Nandi.;Su Ting Tay.;Ming Hui Lee.;Angie Lay Keng Tan.;Xuewen Ong.;Hassan Ashktorab.;Duane Smoot.;Shang Li.;Shyh-Chang Ng.;Bin Tean Teh.;Patrick Tan.
来源: Gut. 2020年69卷2期231-242页
Gastric cancer (GC) is a leading cause of cancer mortality. Previous studies have shown that hepatocyte nuclear factor-4α (HNF4α) is specifically overexpressed in GC and functionally required for GC development. In this study, we investigated, on a genome-wide scale, target genes of HNF4α and oncogenic pathways driven by HNF4α and HNF4α target genes.
2084. Synthetic indicator of the impact of colorectal cancer screening programmes on incidence rates.
The impact of a screening programme on colorectal cancer (CRC) incidence in its target population depends on several variables, including coverage with invitations, participation rate, positivity rate of the screening test, compliance with an invitation to second-level assessment and endoscopists' sensitivity. We propose a synthetic indicator that may account for all the variables influencing the potential impact of a screening programme on CRC incidence.
2085. Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice.
作者: Joana Torres.;Jianzhong Hu.;Akihiro Seki.;Caroline Eisele.;Nilendra Nair.;Ruiqi Huang.;Leonid Tarassishin.;Bindia Jharap.;Justin Cote-Daigneault.;Qixing Mao.;Ilaria Mogno.;Graham J Britton.;Mathieu Uzzan.;Ching-Lynn Chen.;Asher Kornbluth.;James George.;Peter Legnani.;Elana Maser.;Holly Loudon.;Joanne Stone.;Marla Dubinsky.;Jeremiah J Faith.;Jose C Clemente.;Saurabh Mehandru.;Jean-Frederic Colombel.;Inga Peter.
来源: Gut. 2020年69卷1期42-51页
Prenatal and early life bacterial colonisation is thought to play a major role in shaping the immune system. Furthermore, accumulating evidence links early life exposures to the risk of developing IBD later in life. We aimed to assess the effect of maternal IBD on the composition of the microbiome during pregnancy and on the offspring's microbiome.
2088. Prospective colonoscopic study to investigate risk of colorectal neoplasms in first-degree relatives of patients with non-advanced adenomas.
作者: Siew C Ng.;Moe Htet Kyaw.;Bing Yee Suen.;Yee Kit Tse.;Martin C S Wong.;Aric J Hui.;Hui Yee Tak.;James Y W Lau.;Joseph J Y Sung.;Francis K L Chan.
来源: Gut. 2020年69卷2期304-310页
The risk associated with a family history of non-advanced adenoma (non-AA) is unknown. We determined the prevalence of colorectal neoplasms in subjects who have a first-degree relative (FDR) with non-AA compared with subjects who do not have an FDR with adenomas.
2089. Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response.
作者: P G Vaughan-Shaw.;L Zgaga.;L Y Ooi.;E Theodoratou.;M Timofeeva.;V Svinti.;M Walker.;F O'Sullivan.;A Ewing.;S Johnston.;F V N Din.;H Campbell.;S M Farrington.;M G Dunlop.
来源: Gut. 2020年69卷1期103-111页
We assessed the effect of surgical resection of colorectal cancer (CRC) on perioperative plasma vitamin D (25OHD) and C-reactive protein (CRP) level. We investigated the relationship between circulating vitamin D level and CRC survival.
2091. Novel p.K374E variant of CPA1 causes misfolding-induced hereditary pancreatitis with autosomal dominant inheritance.
作者: Balázs Csaba Németh.;Anna Orekhova.;Wenying Zhang.;Shannon A Nortman.;Tyler Thompson.;Péter Hegyi.;Maisam Abu-El-Haija.
来源: Gut. 2020年69卷4期790-792页 2092. Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis.
作者: Sara Lemoinne.;Astrid Kemgang.;Karima Ben Belkacem.;Marjolène Straube.;Sarah Jegou.;Christophe Corpechot.; .;Olivier Chazouillères.;Chantal Housset.;Harry Sokol.
来源: Gut. 2020年69卷1期92-102页
Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these patients. The aim of this study was to assess the fungal gut microbiota in patients with PSC.
2096. Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis.
作者: Christopher J Black.;Nicholas E Burr.;Michael Camilleri.;David L Earnest.;Eamonn Mm Quigley.;Paul Moayyedi.;Lesley A Houghton.;Alexander C Ford.
来源: Gut. 2020年69卷1期74-82页
Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of head-to-head trials. We conducted a network meta-analysis to resolve this uncertainty.
2097. Personalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study.
作者: Arne Gc Bleijenberg.;Joep Eg IJspeert.;Yasmijn J van Herwaarden.;Sabela Carballal.;María Pellisé.;Gerhard Jung.;Tanya M Bisseling.;Iris D Nagtegaal.;Monique E van Leerdam.;Niels van Lelyveld.;Xavier Bessa.;Francisco Rodríguez-Moranta.;Barbara Bastiaansen.;Willemijn de Klaver.;Liseth Rivero.;Manon Cw Spaander.;Jan Jacob Koornstra.;Luis Bujanda.;Francesc Balaguer.;Evelien Dekker.
来源: Gut. 2020年69卷1期112-121页
Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1-2 years. However, yearly surveillance likely leads to overtreatment for many. We prospectively assessed a surveillance protocol aiming to safely reduce the burden of colonoscopies.
2098. Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary.
作者: Dan Turner.;Anne M Griffiths.;David Wilson.;Diane R Mould.;Robert N Baldassano.;Richard K Russell.;Marla Dubinsky.;Melvin B Heyman.;Lissy de Ridder.;Jeffrey Hyams.;Javier Martin de Carpi.;Laurie Conklin.;William A Faubion.;Sibylle Koletzko.;Athos Bousvaros.;Frank M Ruemmele.
来源: Gut. 2020年69卷1期32-41页
The optimal trial design for assessing novel therapies in paediatric IBD (PIBD) is a subject of intense ongoing global discussions and debate among the different stakeholders. However, there is a consensus that the current situation in which most medications used in children with IBD are prescribed as off-label without sufficient paediatric data is unacceptable. Shortening the time lag between adult and paediatric approval of drugs is of the upmost importance. In this position paper we aimed to provide guidance from the global clinical research network (Pediatric Inflammatory Bowel Disease Network, PIBDnet) for designing clinical trials in PIBD in order to facilitate drug approval for children.
2099. Polyploidy spectrum: a new marker in HCC classification.
作者: Myriam Bou-Nader.;Stefano Caruso.;Romain Donne.;Séverine Celton-Morizur.;Julien Calderaro.;Géraldine Gentric.;Mathilde Cadoux.;Antoine L'Hermitte.;Christophe Klein.;Thomas Guilbert.;Miguel Albuquerque.;Gabrielle Couchy.;Valérie Paradis.;Jean-Pierre Couty.;Jessica Zucman-Rossi.;Chantal Desdouets.
来源: Gut. 2020年69卷2期355-364页
Polyploidy is a fascinating characteristic of liver parenchyma. Hepatocyte polyploidy depends on the DNA content of each nucleus (nuclear ploidy) and the number of nuclei per cell (cellular ploidy). Which role can be assigned to polyploidy during human hepatocellular carcinoma (HCC) development is still an open question. Here, we investigated whether a specific ploidy spectrum is associated with clinical and molecular features of HCC.
2100. Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures.
作者: Aatur D Singhi.;Marina N Nikiforova.;Jennifer Chennat.;Georgios I Papachristou.;Asif Khalid.;Mordechai Rabinovitz.;Rohit Das.;Savreet Sarkaria.;M Samir Ayasso.;Abigail I Wald.;Sara E Monaco.;Michael Nalesnik.;N Paul Ohori.;David Geller.;Allan Tsung.;Amer H Zureikat.;Herbert Zeh.;J Wallis Marsh.;Melissa Hogg.;Kenneth Lee.;David L Bartlett.;James F Pingpank.;Abhinav Humar.;Nathan Bahary.;Anil K Dasyam.;Randall Brand.;Kenneth E Fasanella.;Kevin McGrath.;Adam Slivka.
来源: Gut. 2020年69卷1期52-61页
Despite improvements in imaging, serum CA19-9 and pathological evaluation, differentiating between benign and malignant bile duct strictures remains a diagnostic conundrum. Recent developments in next-generation sequencing (NGS) have opened new opportunities for early detection and management of cancers but, to date, have not been rigorously applied to biliary specimens.
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