2084. Living, Rapid Reviews in a Rapidly Evolving World.
In their article, Holmer and colleagues reported the final update of a living review that examined the duration of IgG antibody response, the role of previous SARS-CoV-2 infection to prevent reinfection, and the role of antibodies in protection from reinfection. The editorialist discusses the challenge of living reviews as new evidence emerges and the relevant clinical questions evolve.
2086. Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers : A Randomized Trial.
作者: Mark Loeb.;Amy Bartholomew.;Madiha Hashmi.;Wadea Tarhuni.;Mohamed Hassany.;Ilan Youngster.;Ranjani Somayaji.;Oscar Larios.;Joseph Kim.;Bayan Missaghi.;Joseph V Vayalumkal.;Dominik Mertz.;Zain Chagla.;Maureen Cividino.;Karim Ali.;Sarah Mansour.;Lana A Castellucci.;Charles Frenette.;Leighanne Parkes.;Mark Downing.;Matthew Muller.;Verne Glavin.;Jennifer Newton.;Ravi Hookoom.;Jerome A Leis.;James Kinross.;Stephanie Smith.;Sayem Borhan.;Pardeep Singh.;Eleanor Pullenayegum.;John Conly.
来源: Ann Intern Med. 2022年175卷12期1629-1638页
It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators.
2087. Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial.
作者: Gail E Potter.;Tyler Bonnett.;Kevin Rubenstein.;David A Lindholm.;Rekha R Rapaka.;Sarah B Doernberg.;David C Lye.;Richard A Mularski.;Noreen A Hynes.;Susan Kline.;Catharine I Paules.;Cameron R Wolfe.;Maria G Frank.;Nadine G Rouphael.;Gregory A Deye.;Daniel A Sweeney.;Rhonda E Colombo.;Richard T Davey.;Aneesh K Mehta.;Jennifer A Whitaker.;Jose G Castro.;Alpesh N Amin.;Christopher J Colombo.;Corri B Levine.;Mamta K Jain.;Ryan C Maves.;Vincent C Marconi.;Robert Grossberg.;Sameh Hozayen.;Timothy H Burgess.;Robert L Atmar.;Anuradha Ganesan.;Carlos A Gomez.;Constance A Benson.;Diego Lopez de Castilla.;Neera Ahuja.;Sarah L George.;Seema U Nayak.;Stuart H Cohen.;Tahaniyat Lalani.;William R Short.;Nathaniel Erdmann.;Kay M Tomashek.;Pablo Tebas.
来源: Ann Intern Med. 2022年175卷12期1716-1727页
The COVID-19 standard of care (SOC) evolved rapidly during 2020 and 2021, but its cumulative effect over time is unclear.
2089. Outpatient Treatment of Confirmed COVID-19: Living, Rapid Practice Points From the American College of Physicians (Version 1).
作者: Amir Qaseem.;Jennifer Yost.;Matthew C Miller.;Rebecca Andrews.;Janet A Jokela.;Mary Ann Forciea.;George M Abraham.;Linda L Humphrey.; .;Rachael A Lee.;Mark P Tschanz.;Itziar Etxeandia-Ikobaltzeta.;Curtis Harrod.;Tatyana Shamliyan.;Karla Umana.
来源: Ann Intern Med. 2023年176卷1期115-124页
Strategies to manage COVID-19 in the outpatient setting continue to evolve as new data emerge on SARS-CoV-2 variants and the availability of newer treatments. The Scientific Medical Policy Committee (SMPC) of the American College of Physicians (ACP) developed these living, rapid practice points to summarize the best available evidence on the treatment of adults with confirmed COVID-19 in an outpatient setting. These practice points do not evaluate COVID-19 treatments in the inpatient setting or adjunctive COVID-19 treatments in the outpatient setting.
2091. Major Update 2: Antibody Response and Risk for Reinfection After SARS-CoV-2 Infection-Final Update of a Living, Rapid Review.
作者: Haley K Holmer.;Katherine Mackey.;Celia V Fiordalisi.;Mark Helfand.
来源: Ann Intern Med. 2023年176卷1期85-91页
The durability of the antibody response after SARS-CoV-2 infection and the role of antibodies in protection against reinfection are unclear.
2092. Ongoing Need for Clinical Trials and Contemporary End Points for Outpatient COVID-19.
The American College of Physicians presents recommendations for the outpatient treatment of COVID-19 based on Sommer and colleagues' systematic review. The editorialists commend the authors of the recommendations and review for trying to summarize the rapidly evolving literature into clear practice points and discuss the challenges of continually updating reviews and associated recommendations as new evidence emerges and relevant outcomes evolve.
2093. Comparative Effectiveness of Mask Type in Preventing SARS-CoV-2 in Health Care Workers: Uncertainty Persists.
Two and a half years after the emergence of the COVID-19 pandemic, Loeb and colleagues reported the first randomized trial of N95 respirators versus medical masks in health care workers. The editorialist discusses the findings and highlights remaining areas of uncertainty about optimal mask type.
2094. Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Review for the American College of Physicians.
作者: Isolde Sommer.;Andreea Dobrescu.;Dominic Ledinger.;Isabel Moser.;Kylie Thaler.;Emma Persad.;Martin Fangmeyer.;Robert Emprechtinger.;Irma Klerings.;Gerald Gartlehner.
来源: Ann Intern Med. 2023年176卷1期92-104页
Clinicians and patients want to know the benefits and harms of outpatient treatment options for SARS-CoV-2 infection.
2095. Participant Recruitment From Low- and Middle-Income Countries for Pivotal Trials of Drugs Approved by the U.S. Food and Drug Administration : A Cross-Sectional Analysis.
作者: Fareed A Awan.;Andrew B Becker.;Yuetong Wang.;Jonathan Kimmelman.
来源: Ann Intern Med. 2022年175卷12期1675-1684页
Many participants in clinical trials supporting U.S. Food and Drug Administration (FDA) drug approvals are recruited from outside the United States, including from low- and middle-income countries (LMICs). Where participants are recruited for pivotal trials has implications for ethical research conduct and generalizability.
2096. Health Care During Incarceration: A Policy Position Paper From the American College of Physicians.
作者: Newton E Kendig.;Renee Butkus.;Suja Mathew.;David Hilden.; .
来源: Ann Intern Med. 2022年175卷12期1742-1745页
The American College of Physicians (ACP) has a long-standing commitment to improving the health of all Americans and opposes any form of discrimination in the delivery of health care services. ACP is committed to working toward fully understanding and supporting the unique needs of the incarcerated population and eliminating health disparities for these persons. In this position paper, ACP offers recommendations to policymakers and administrators to improve the health and well-being of persons incarcerated in adult correctional facilities.
2099. Correction: Risk for Recurrent Venous Thromboembolism and Bleeding With Apixaban Compared With Rivaroxaban and Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Valvular Atrial Fibrillation.
来源: Ann Intern Med. 2022年175卷11期1627-1628页
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