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2061. Effect of Calorie-Unrestricted Low-Carbohydrate, High-Fat Diet Versus High-Carbohydrate, Low-Fat Diet on Type 2 Diabetes and Nonalcoholic Fatty Liver Disease : A Randomized Controlled Trial.
作者: Camilla Dalby Hansen.;Eva-Marie Gram-Kampmann.;Johanne Kragh Hansen.;Mie Balle Hugger.;Bjørn Stæhr Madsen.;Jane Møller Jensen.;Sara Olesen.;Nikolaj Torp.;Ditlev Nytoft Rasmussen.;Maria Kjærgaard.;Stine Johansen.;Katrine Prier Lindvig.;Peter Andersen.;Katrine Holtz Thorhauge.;Jan Christian Brønd.;Pernille Hermann.;Henning Beck-Nielsen.;Sönke Detlefsen.;Torben Hansen.;Kurt Højlund.;Maja Sofie Thiele.;Mads Israelsen.;Aleksander Krag.
来源: Ann Intern Med. 2023年176卷1期10-21页
It remains unclear if a low-carbohydrate, high-fat (LCHF) diet is a possible treatment strategy for type 2 diabetes mellitus (T2DM), and the effect on nonalcoholic fatty liver disease (NAFLD) has not been investigated.
2062. Monkeypox in Montréal: Epidemiology, Phylogenomics, and Public Health Response to a Large North American Outbreak.
作者: Luke B Harrison.;Geneviève Bergeron.;Geneviève Cadieux.;Hugues Charest.;Judith Fafard.;Inès Levade.;Antoine Cloutier Blais.;Emmanuelle Huchet.;Benoît Trottier.;Dragos Vlad.;Jason Szabo.;Réjean Thomas.;Sébastien Poulin.;Christina Greenaway.;Gerasimos J Zaharatos.;Matthew Oughton.;Arpita Chakravarti.;Robert Pilarski.;Andrew Bui-Nguyen.;Khadija Benomar.;Michael D Libman.;Donald C Vinh.;Ana T Duggan.;Morag Graham.;Marina B Klein.;Sapha Barkati.
来源: Ann Intern Med. 2023年176卷1期67-76页
Monkeypox, a viral zoonotic disease, is causing a global outbreak outside of endemic areas.
2065. In adults, risk for infective endocarditis varied for invasive dental procedures and by antibiotic prophylaxis.
Thornhill MH, Gibson TB, Yoon F, et al. Antibiotic prophylaxis against infective endocarditis before invasive dental procedures. J Am Coll Cardiol. 2022;80:1029-41. 35987887.
2067. In THA or TKA, risk for symptomatic VTE was higher with aspirin vs. enoxaparin at 90 d.
CRISTAL Study Group; Sidhu VS, Kelly TL, Pratt N, et al. Effect of aspirin vs enoxaparin on symptomatic venous thromboembolism in patients undergoing hip or knee arthroplasty: the CRISTAL randomized trial. JAMA. 2022;328:719-27. 35997730.
2068. In generally healthy adults, supplemental vitamin D3 did not reduce fractures vs. placebo at 5 y.
LeBoff MS, Chou SH, Ratliff KA, et al. Supplemental vitamin D and incident fractures in midlife and older adults. N Engl J Med. 2022;387:299-309. 35939577.
2069. In older men, an invitation for comprehensive CV screening did not reduce death at 5.6 y.
Lindholt JS, Søgaard R, Rasmussen LM, et al. Five-year outcomes of the Danish Cardiovascular Screening (DANCAVAS) trial. N Engl J Med. 2022;387:1385-94. 36027560.
2070. In ischemic left ventricular systolic dysfunction, adding PCI to medical therapy did not reduce death or HF hospitalization.
Perera D, Clayton T, O'Kane PD, et al. Percutaneous revascularization for ischemic left ventricular dysfunction. N Engl J Med. 2022;387:1351-60. 36027563.
2073. Long-Term Stability of Coverage Among Michigan Medicaid Beneficiaries : A Cohort Study.
作者: Chima D Ndumele.;Anthony Lollo.;Harlan M Krumholz.;Mark Schlesinger.;Jacob Wallace.
来源: Ann Intern Med. 2023年176卷1期22-28页
Medicaid, the primary source of insurance coverage for disadvantaged Americans, was originally designed as a temporary safety-net program. No studies have used long-run data to assess the recent use of the program by beneficiaries.
2074. In the general population, salt substitutes vs. regular salt reduce BP levels, CV outcomes, and mortality.
Yin X, Rodgers A, Perkovic A, et al. Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis. Heart. 2022;108:1608-15. 35945000.
2075. BP-lowering drugs reduced major CV events by similar amounts in patients with and without type 2 diabetes.
Nazarzadeh M, Bidel Z, Canoy D, et al. Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis. Lancet Diabetes Endocrinol. 2022;10:645-54. 35878651.
2076. In monkeypox, risk for some symptoms was greater in MSM with vs. without receptive anal contact.
Tarín-Vicente EJ, Alemany A, Agud-Dios M, et al. Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study. Lancet. 2022;400:661-9. 35952705.
2077. In acute decompensated HF, adding acetazolamide to IV loop diuretics reduced congestion at 3 d.
Mullens W, Dauw J, Martens P, et al. Acetazolamide in acute decompensated heart failure with volume overload. N Engl J Med. 2022;387:1185-95. 36027559.
2078. Comparative Effectiveness of Team-Based Care With and Without a Clinical Decision Support System for Diabetes Management : A Cluster Randomized Trial.
作者: Xiulin Shi.;Jiang He.;Mingzhu Lin.;Changqin Liu.;Bing Yan.;Haiqu Song.;Caihong Wang.;Fangsen Xiao.;Peiying Huang.;Liying Wang.;Zhibin Li.;Yinxiang Huang.;Mulin Zhang.;Chung-Shiuan Chen.;Katherine Obst.;Lizheng Shi.;Weihua Li.;Shuyu Yang.;Guanhua Yao.;Xuejun Li.
来源: Ann Intern Med. 2023年176卷1期49-58页
Uncontrolled hyperglycemia, hypercholesterolemia, and hypertension are common in persons with diabetes.
2079. Effects of Dapagliflozin on Hospitalizations in Patients With Chronic Kidney Disease : A Post Hoc Analysis of DAPA-CKD.
作者: Meir Schechter.;Niels Jongs.;Glenn M Chertow.;Ofri Mosenzon.;John J V McMurray.;Ricardo Correa-Rotter.;Peter Rossing.;Anna Maria Langkilde.;C David Sjöström.;Robert D Toto.;David C Wheeler.;Hiddo J L Heerspink.
来源: Ann Intern Med. 2023年176卷1期59-66页
Acute hospitalizations are common in patients with chronic kidney disease (CKD) and often lead to decreases in health-related quality of life and increased care costs.
2080. In CV disease, clopidogrel reduces nonfatal MI and MACE vs. aspirin but not stroke or mortality.
Tasoudis PT, Kyriakoulis IG, Sagris D, et al. Clopidogrel monotherapy versus aspirin monotherapy in patients with established cardiovascular disease: systematic review and meta-analysis. Thromb Haemost. 2022;122:1879-87. 35577054.
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