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2025. Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer: The ALEXANDRA/IMpassion030 Randomized Clinical Trial.
作者: Michail Ignatiadis.;Andrew Bailey.;Heather McArthur.;Sarra El-Abed.;Evandro de Azambuja.;Otto Metzger.;Stephen Y Chui.;Max Dieterich.;Thomas Perretti.;Esther Shearer-Kang.;Luciana Molinero.;Günther G Steger.;Jacek Jassem.;Soo Chin Lee.;Michaela Higgins.;Jose Zarba.;Marcus Schmidt.;Henry Gomez.;Angel Guerrero Zotano.;Luca Moscetti.;Joanne Chiu.;Elisabetta Munzone.;Noa Efrat Ben-Baruch.;Emilio Bajetta.;Shinji Ohno.;Seock-Ah Im.;Gustavo Werutsky.;Einav Nili Gal-Yam.;Xavier Gonzalez Farre.;Ling-Ming Tseng.;William Jacot.;Oleg Gluz.;Zhimin Shao.;Yaroslav Shparyk.;Anastasia Zimina.;Eric Winer.;David A Cameron.;Giuseppe Viale.;Shigehira Saji.;Richard Gelber.;Martine Piccart.
来源: JAMA. 2025年333卷13期1150-60页
Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- to 18-month life expectancy. Until recently, one strategy for treating early-stage triple-negative breast cancer was chemotherapy after surgery. However, it was not known whether the addition of immune therapy to postsurgery chemotherapy would be beneficial.
2031. Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers: The IN-PEACE Randomized Clinical Trial.
作者: Greg A Sachs.;Nina M Johnson.;Sujuan Gao.;Alexia M Torke.;Susan E Hickman.;Amy Pemberton.;Andrea Vrobel.;Minmin Pan.;Jennifer West.;Kurt Kroenke.
来源: JAMA. 2025年333卷11期962-971页
Care management benefits community-dwelling patients with dementia, but studies include few patients with moderate to severe dementia or from racial and ethnic minority populations, lack palliative care, and seldom reduce health care utilization.
2034. Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers: The D-CARE Randomized Clinical Trial.
作者: David B Reuben.;Thomas M Gill.;Alan Stevens.;Jeff Williamson.;Elena Volpi.;Maya Lichtenstein.;Lee A Jennings.;Rebecca Galloway.;Jenny Summapund.;Katy Araujo.;David Bass.;Lisa Weitzman.;Zaldy S Tan.;Leslie Evertson.;Mia Yang.;Katherine Currie.;Aval-Na'Ree S Green.;Sybila Godoy.;Sitara Abraham.;Jordan Reese.;Rafael Samper-Ternent.;Roxana M Hirst.;Pamela Borek.;Peter Charpentier.;Can Meng.;James Dziura.;Yunshan Xu.;Eleni A Skokos.;Zili He.;Sherry Aiudi.;Peter Peduzzi.;Erich J Greene.; .
来源: JAMA. 2025年333卷11期950-961页
The effectiveness of different approaches to dementia care is unknown.
2038. Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial.
作者: .;Kristy Atherton.;James Brown.;Hamish Clouston.;Pete Coe.;Rui Duarte.;Nagendra N Dudi-Venkata.;Sarah Duff.;Natasha Egoroff.;Rebecca Fish.;James Glasbey.;Natalie Ives.;Manjinder Kaur.;Laura Magill.;Samir Mehta.;Thomas Pinkney.;Peter Pockney.;Toby Richards.;Tarik Sammour.;Hema Sekhar.;Yash Sinha.;Martyn Stott.;Richard Wilkin.
来源: JAMA. 2025年333卷10期853-863页
Patients undergoing unplanned abdominal surgical procedures are at increased risk of surgical site infection (SSI). It is not known if incisional negative pressure wound therapy (iNPWT) can reduce SSI rates in this setting.
2040. Essential Thrombocythemia: A Review.
作者: Ayalew Tefferi.;Naseema Gangat.;Giuseppe Gaetano Loscocco.;Paola Guglielmelli.;Natasha Szuber.;Animesh Pardanani.;Attilio Orazi.;Tiziano Barbui.;Alessandro Maria Vannucchi.
来源: JAMA. 2025年333卷8期701-714页
Essential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. The annual incidence rate of essential thrombocythemia in the US is 1.5/100 000 persons.
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