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1. Bifidobacterium catenulatum boosts anti-PD-1 efficacy in microsatellite stable colorectal cancer via activating CD8+ T cells.
作者: Xiang Li.;Mingxu Xie.;Jason Xing Kang.;Yue Chen.;Jing Han.;Yinnan Chen.;Qian Chen.;Tianyu Yu.;Shuyan Liu.;Zhenlin Ouyang.;Qiong Sun.;Kai Li.;Shaoqiang Zhang.;Junjun She.;Jun Yu.
来源: Gut. 2026年
Certain gut bacteria are associated with improved responses to immunotherapy.
2. Quantifying artificial sweeteners and emulsifiers in Crohn's disease and its relationship with disease activity: the ENIGMA study - a novel and targeted approach.
作者: Jingwan Zhang.;Jielun Hu.;Xinyi Tang.;Yanjiao Ruan.;Fangjia Hao.;Wenqing Zhang.;Gina Trakman.;Amy L Hamilton.;Winnie Lin.;Yang Sun.;Jessica Y L Ching.;Jing Jie Teh.;Seungha Kang.;Amy Wilson-O' Brien.;Annalise Stanley.;Lin Zhang.;Joseph J Y Sung.;Jun Yu.;Yinglei Miao.;Francis K L Chan.;Mark Morrison.;Michael Kamm.;Siew C Ng.
来源: Gut. 2026年
Food additives have been linked to increased Crohn's disease (CD) risk and activity, but their human quantification has not been explored.
3. RNA binding protein CAPRIN1 suppresses STAT1 translation and interferon signalling to promote HBV replication.
作者: Jing Peng.;Zheng Ding.;Qu Liu.;Liwei Zhang.;Juan Chen.;Guixi Chen.;Yuebin Gao.;Siyu Wang.;Xiaomin Tian.;Yuqiu Wei.;Ourania Andrisani.;Yixuan Li.;Fazheng Ren.;Jiazeng Sun.
来源: Gut. 2026年
A G-quadruplex (rG4) structure within 5' untranslated region (5'UTR) of Signal Transducer and Activator of Transcription 1 (STAT1) messenger RNA (mRNA) functions as a translational brake modulating STAT1 translation and regulating interferon (IFN) response. We hypothesised that rG4-interacting proteins could be pivotal modulators of STAT1 expression and, consequently, IFN therapy for HBV resistance.
4. Selenoprotein P deficiency drives hepatocellular carcinoma progression via induction of neutrophil senescence and immunosuppressive microenvironment.
作者: Jiazheng Jiao.;Lele Song.;Shengjun Xu.;Yuan Xue.;Yanyan Liao.;Keying Xu.;Qian Wen.;Kai Xiang.;Rongrong Chen.;Xiaoxia Dong.;Weiwei Ji.;Yinlong Guo.;Gang Li.;Haibiao Bao.;Xiao Xu.;Lixing Zhan.
来源: Gut. 2026年
The hepatocellular carcinoma (HCC) immune microenvironment is heavily influenced by immunosuppressive neutrophils, yet the mechanisms driving their senescence-associated reprogramming remain elusive.
5. Commonly prescribed drugs as risk factors for Clostridioides difficile infections: a Swedish population-based case-control study.
作者: Annelies Boven.;Harry Vranken.;Erika Vlieghe.;Annemarie Boleij.;Katja Fall.;Lars Engstrand.;Nele Brusselaers.
来源: Gut. 2026年
Clostridioides difficile infections (CDIs) are associated with antibiotic use, although the link with other drugs remains underexplored.
6. Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes.
作者: Yuping Chen.;Bingtian Dong.;Xinrui Jin.;Chuan Liu.;Ming-Hua Zheng.;Xiao Liang.;Yameng Sun.;Hye Won Lee.;Huapeng Lin.;Emmanuel Tsochatzis.;Salvatore Petta.;Elisabetta Bugianesi.;Masato Yoneda.;Hannes Hagström.;Jérôme Boursier.;José Luis Calleja.;George Boon-Bee Goh.;Wah-Kheong Chan.;Rocio Gallego-Durán.;Arun J Sanyal.;Victor de Lédinghen.;Philip N Newsome.;Jian-Gao Fan.;Laurent Castéra.;Michelle Lai.;Céline Fournier-Poizat.;Grace Lai-Hung Wong.;Grazia Pennisi.;Angelo Armandi.;Atsushi Nakajima.;Wen-Yue Liu.;Ying Shang.;Marc de Saint-Loup.;Elba Llop.;Kevin Kim Jun Teh.;Carmen Lara-Romero.;Amon Asgharpour.;Sara Mahgoub.;Mandy Sau-Wai Chan.;Adrien Lannes.;Manuel Romero-Gomez.;Airong Hu.;Yiling Li.;Qing-Lei Zeng.;Wei Gou.;Hua Bian.;Xiao Han.;Chenlin Sun.;Seung Up Kim.;Terry Cheuk-Fung Yip.;Gao-Jun Teng.;Vincent Wai-Sun Wong.;Xiaolong Qi.; .
来源: Gut. 2026年75卷3期576-587页
Current guidelines recommend a two-step approach for risk stratification of metabolic dysfunction-associated steatotic liver disease (MASLD), starting with Fibrosis-4 index (FIB-4) followed by liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE).
8. Diagnostic endoscopic resection for assessing potential residual disease after neoadjuvant therapy for oesophageal adenocarcinoma.
作者: Aleksandra Sztogrin-Pluta.;Katarzyna Polomska.;Joanna Podgorska.;Andrzej Mroz.;Tomasz Olesinski.;Nastazja Dagny Pilonis.;Michal F Kaminski.
来源: Gut. 2026年 9. Stage-dependent gut microbiome and functional signatures across the liver disease spectrum: an integrative multicohort study.
作者: Jorge F Vázquez-Castellanos.;Sang Jun Yoon.;Sung-Min Won.;Jeroen Raes.;Hak Cheol Kwon.;Jiyeon Si.;Ki Tae Suk.
来源: Gut. 2026年
The gut-liver axis plays a critical role in liver disease progression; however, how gut microbial ecology and function vary across disease stages remains unclear.
11. Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model.
作者: Muyiwa Awoniyi.;Mohamed El Hag.;Josue Hernandez.;Qijun Yang.;Nicholas Evans.;Ina Nemet.;Billy Ngo.;Deniz Coskuner.;Julie Zhou.;Morgan Farmer.;Lianyong Su.;Huiping Zhou.;Jeffery Roach.;Thaddeus Stappenbeck.;R Balfour Sartor.
来源: Gut. 2026年
Primary sclerosing cholangitis-associated UC (PSC-UC) carries excess colorectal neoplasia despite often mild-appearing endoscopy, implicating persistent microscopic inflammation and microbiota-bile acid (BA) dysfunction.
14. Extrinsic lipids are absorbed and accumulate in colorectal cancer.
作者: Klaus Peter Janssen.;Marijana Basic.;Silvia Bolsega.;Amira Metwaly.;Florian Jokisch.;Sophia von Gamm.;Josef Scheiber.;Ralph Burkhardt.;Gerhard Liebisch.;Klaus Neuhaus.;Sarah Brunner.;Thomas Clavel.;Esther Wortmann.;Olivia I Coleman.;Dirk Haller.;Andre Bleich.;Sabrina Krautbauer.;Josef Ecker.
来源: Gut. 2026年
Colorectal cancer (CRC) exhibits increased levels of arachidonic acid-derived pro-inflammatory derivatives indicating an uptake of dietary polyunsaturated fatty acids (PUFAs).
15. Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma.
作者: Virag Gehl.;Colm J O'Rourke.;Martin Cornillet.;Orestis Nousias.;Achilleas Fardellas.;Supaporn Yangngam.;Magdalena Rogalska-Taranta.;Blanca I Aldana.;Dan Hogdall.;Jens U Marquardt.;Niklas K Björkström.;Jesper B Andersen.
来源: Gut. 2026年
High serum levels of interleukin 6 (IL-6) predict poor prognosis in intrahepatic cholangiocarcinoma (iCCA), a malignancy that often develops in a chronically inflamed milieu. Here, tumour cells are capable of autonomously producing and engaging autocrine IL-6 signalling, yet the consequences of this remain unknown.
16. Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study.
作者: Yusheng Guo.;Guilin Zhang.;Xiaona Fu.;Shanshan Jiang.;Yi Li.;Shanmei Li.;Xiaofang Guo.;Xiaolin Zhang.;Chang Zhao.;Rong Ding.;Lei Yu.;Xuegang Yang.;Kai Zhao.;Yuxin Sun.;QiuPing Liu.;YuDong Zhang.;Xuhua Duan.;Hui Zhao.;Jiahua Zou.;Bin Liang.;Lian Yang.;Chuansheng Zheng.;Xuefeng Kan.
来源: Gut. 2026年
Survival outcomes after transarterial chemoembolisation (TACE) vary in hepatocellular carcinoma (HCC) patients, and existing prognostic scores and imaging models often lack generalisability and biological interpretability.
17. CAV1-DOT1L axis in TAM-derived EVs orchestrates VM and sensitises PDAC to combined VM and VEGF targeting.
作者: Ziyu Liu.;Ying Zhang.;Haonan Wu.;Han Liu.;Tongjia Chu.;Huan Liu.;Jian Zhang.;Feng Wei.
来源: Gut. 2026年
Vasculogenic mimicry (VM) is a non-endothelial vascularisation programme sustaining pancreatic ductal adenocarcinoma (PDAC) perfusion and metastasis, yet its regulators and therapeutic vulnerabilities remain unclear.
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