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1. Screening for Syphilis Infection During Pregnancy: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
作者: Gary N Asher.;Meera Viswanathan.;Afua Takyi.;Jennifer Cook Middleton.;Claire Baker.;Leila C Kahwati.
来源: JAMA. 2025年 2. Screening for Syphilis Infection During Pregnancy: US Preventive Services Task Force Reaffirmation Recommendation Statement.
作者: .;Michael Silverstein.;John B Wong.;Esa M Davis.;David Chelmow.;Tumaini Rucker Coker.;Alicia Fernandez.;Ericka Gibson.;Carlos Roberto Jaén.;Marie Krousel-Wood.;Sei Lee.;Wanda K Nicholson.;Goutham Rao.;John M Ruiz.;James Stevermer.;Joel Tsevat.;Sandra Millon Underwood.;Sarah Wiehe.
来源: JAMA. 2025年
Untreated syphilis infection during pregnancy can be passed to the fetus, causing congenital syphilis. Congenital syphilis is associated with premature birth, low birth weight, stillbirth, neonatal death, and significant abnormalities in the infant such as deformed bones, anemia, enlarged liver and spleen, jaundice, brain and nerve problems (eg, permanent vision or hearing loss), and meningitis. In 2023, there were 3882 cases of congenital syphilis in the US, including 279 congenital syphilis-related stillbirths and neonatal/infant deaths, the highest number reported in more than 30 years.
4. The Microbiome and Cancer: A Translational Science Review.
Growing evidence suggests that microbes located within the gastrointestinal tract and other anatomical locations influence the development and progression of diseases such as cancer.
6. Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial.
作者: Scott R Garrison.;Jeffrey A Bakal.;Michael R Kolber.;Christina S Korownyk.;Lee A Green.;Jessica E M Kirkwood.;Finlay A McAlister.;Raj S Padwal.;Richard Lewanczuk.;Michael D Hill.;Alexander G Singer.;Alan Katz.;Michael D Kelmer.;Armine Gayayan.;Farah N Campbell.;Ana Vucenovic.;Nathan R Archibald.;Jack M S Yeung.;Erik R E Youngson.;Kimberlyn McGrail.;Braden G O'Neill.;Michelle Greiver.;Donna P Manca.;Roni Y Kraut.;Ting Wang.;Braden J Manns.;Dee A Mangin.;Cathy MacLean.;James McCormack.;Sabrina T Wong.;Colleen Norris.;G Michael Allan.
来源: JAMA. 2025年
Whether administration of blood pressure medications at bedtime instead of in the morning reduces cardiovascular risk is unknown, as findings from large clinical trials have not been consistent. There is also concern that bedtime antihypertensive use could induce glaucoma-related visual loss or other hypotensive/ischemic adverse effects.
14. Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults ≥50 Years: A Randomized Clinical Trial.
作者: Amanda K Rudman Spergel.;Iris Wu.;Weiping Deng.;Jose Cardona.;Kimball Johnson.;Ivette Espinosa-Fernandez.;Melissa Sinkiewicz.;Veronica Urdaneta.;Lizbeth Carmona.;Kristin Schaefers.;Bethany Girard.;Yamuna D Paila.;Darshan Mehta.;Benoit Callendret.;Lusine Kostanyan.;Jintanat Ananworanich.;Jacqueline Miller.;Rituparna Das.;Christine A Shaw.
来源: JAMA. 2025年
Uptake of recommended seasonal influenza and COVID-19 vaccines remains suboptimal.
16. Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence: The MUSA Randomized Clinical Trial.
作者: Heidi S Harvie.;Shawn A Menefee.;Holly E Richter.;Vivian W Sung.;Christopher J Chermansky.;David D Rahn.;Cindy L Amundsen.;Lily A Arya.;Evan Rhodes.;Donna Mazloomdoost.;Sonia Thomas.; .
来源: JAMA. 2025年
Mixed urinary incontinence, which includes both stress and urgency urinary incontinence, adversely affects quality of life and can be difficult to manage. Studies comparing procedural-based treatments for mixed urinary incontinence are lacking.
17. Endometriosis: A Review.
作者: Sawsan As-Sanie.;Scott C Mackenzie.;Leigh Morrison.;Andrew Schrepf.;Krina T Zondervan.;Andrew W Horne.;Stacey A Missmer.
来源: JAMA. 2025年
Endometriosis is a chronic, estrogen-dependent, inflammatory disease defined by endometrial-like tissue (lesions) outside the uterine lining. It affects up to 10% of women worldwide, and 9 million women in the US, during reproductive years.
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