当前位置: 首页 >> 检索结果
1. Selenoprotein P deficiency drives hepatocellular carcinoma progression via induction of neutrophil senescence and immunosuppressive microenvironment.
作者: Jiazheng Jiao.;Lele Song.;Shengjun Xu.;Yuan Xue.;Yanyan Liao.;Keying Xu.;Qian Wen.;Kai Xiang.;Rongrong Chen.;Xiaoxia Dong.;Weiwei Ji.;Yinlong Guo.;Gang Li.;Haibiao Bao.;Xiao Xu.;Lixing Zhan.
来源: Gut. 2026年
The hepatocellular carcinoma (HCC) immune microenvironment is heavily influenced by immunosuppressive neutrophils, yet the mechanisms driving their senescence-associated reprogramming remain elusive.
2. Commonly prescribed drugs as risk factors for Clostridioides difficile infections: a Swedish population-based case-control study.
作者: Annelies Boven.;Harry Vranken.;Erika Vlieghe.;Annemarie Boleij.;Katja Fall.;Lars Engstrand.;Nele Brusselaers.
来源: Gut. 2026年
Clostridioides difficile infections (CDIs) are associated with antibiotic use, although the link with other drugs remains underexplored.
3. Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes.
作者: Yuping Chen.;Bingtian Dong.;Xinrui Jin.;Chuan Liu.;Ming-Hua Zheng.;Xiao Liang.;Yameng Sun.;Hye Won Lee.;Huapeng Lin.;Emmanuel Tsochatzis.;Salvatore Petta.;Elisabetta Bugianesi.;Masato Yoneda.;Hannes Hagström.;Jérôme Boursier.;José Luis Calleja.;George Boon-Bee Goh.;Wah-Kheong Chan.;Rocio Gallego-Durán.;Arun J Sanyal.;Victor de Lédinghen.;Philip N Newsome.;Jian-Gao Fan.;Laurent Castéra.;Michelle Lai.;Céline Fournier-Poizat.;Grace Lai-Hung Wong.;Grazia Pennisi.;Angelo Armandi.;Atsushi Nakajima.;Wen-Yue Liu.;Ying Shang.;Marc de Saint-Loup.;Elba Llop.;Kevin Kim Jun Teh.;Carmen Lara-Romero.;Amon Asgharpour.;Sara Mahgoub.;Mandy Sau-Wai Chan.;Adrien Lannes.;Manuel Romero-Gomez.;Airong Hu.;Yiling Li.;Qing-Lei Zeng.;Wei Gou.;Hua Bian.;Xiao Han.;Chenlin Sun.;Seung Up Kim.;Terry Cheuk-Fung Yip.;Gao-Jun Teng.;Vincent Wai-Sun Wong.;Xiaolong Qi.; .
来源: Gut. 2026年75卷3期576-587页
Current guidelines recommend a two-step approach for risk stratification of metabolic dysfunction-associated steatotic liver disease (MASLD), starting with Fibrosis-4 index (FIB-4) followed by liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE).
5. Diagnostic endoscopic resection for assessing potential residual disease after neoadjuvant therapy for oesophageal adenocarcinoma.
作者: Aleksandra Sztogrin-Pluta.;Katarzyna Polomska.;Joanna Podgorska.;Andrzej Mroz.;Tomasz Olesinski.;Nastazja Dagny Pilonis.;Michal F Kaminski.
来源: Gut. 2026年 6. Stage-dependent gut microbiome and functional signatures across the liver disease spectrum: an integrative multicohort study.
作者: Jorge F Vázquez-Castellanos.;Sang Jun Yoon.;Sung-Min Won.;Jeroen Raes.;Hak Cheol Kwon.;Jiyeon Si.;Ki Tae Suk.
来源: Gut. 2026年
The gut-liver axis plays a critical role in liver disease progression; however, how gut microbial ecology and function vary across disease stages remains unclear.
8. Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model.
作者: Muyiwa Awoniyi.;Mohamed El Hag.;Josue Hernandez.;Qijun Yang.;Nicholas Evans.;Ina Nemet.;Billy Ngo.;Deniz Coskuner.;Julie Zhou.;Morgan Farmer.;Lianyong Su.;Huiping Zhou.;Jeffery Roach.;Thaddeus Stappenbeck.;R Balfour Sartor.
来源: Gut. 2026年
Primary sclerosing cholangitis-associated UC (PSC-UC) carries excess colorectal neoplasia despite often mild-appearing endoscopy, implicating persistent microscopic inflammation and microbiota-bile acid (BA) dysfunction.
11. Extrinsic lipids are absorbed and accumulate in colorectal cancer.
作者: Klaus Peter Janssen.;Marijana Basic.;Silvia Bolsega.;Amira Metwaly.;Florian Jokisch.;Sophia von Gamm.;Josef Scheiber.;Ralph Burkhardt.;Gerhard Liebisch.;Klaus Neuhaus.;Sarah Brunner.;Thomas Clavel.;Esther Wortmann.;Olivia I Coleman.;Dirk Haller.;Andre Bleich.;Sabrina Krautbauer.;Josef Ecker.
来源: Gut. 2026年
Colorectal cancer (CRC) exhibits increased levels of arachidonic acid-derived pro-inflammatory derivatives indicating an uptake of dietary polyunsaturated fatty acids (PUFAs).
12. Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma.
作者: Virag Gehl.;Colm J O'Rourke.;Martin Cornillet.;Orestis Nousias.;Achilleas Fardellas.;Supaporn Yangngam.;Magdalena Rogalska-Taranta.;Blanca I Aldana.;Dan Hogdall.;Jens U Marquardt.;Niklas K Björkström.;Jesper B Andersen.
来源: Gut. 2026年
High serum levels of interleukin 6 (IL-6) predict poor prognosis in intrahepatic cholangiocarcinoma (iCCA), a malignancy that often develops in a chronically inflamed milieu. Here, tumour cells are capable of autonomously producing and engaging autocrine IL-6 signalling, yet the consequences of this remain unknown.
13. Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study.
作者: Yusheng Guo.;Guilin Zhang.;Xiaona Fu.;Shanshan Jiang.;Yi Li.;Shanmei Li.;Xiaofang Guo.;Xiaolin Zhang.;Chang Zhao.;Rong Ding.;Lei Yu.;Xuegang Yang.;Kai Zhao.;Yuxin Sun.;QiuPing Liu.;YuDong Zhang.;Xuhua Duan.;Hui Zhao.;Jiahua Zou.;Bin Liang.;Lian Yang.;Chuansheng Zheng.;Xuefeng Kan.
来源: Gut. 2026年
Survival outcomes after transarterial chemoembolisation (TACE) vary in hepatocellular carcinoma (HCC) patients, and existing prognostic scores and imaging models often lack generalisability and biological interpretability.
14. CAV1-DOT1L axis in TAM-derived EVs orchestrates VM and sensitises PDAC to combined VM and VEGF targeting.
作者: Ziyu Liu.;Ying Zhang.;Haonan Wu.;Han Liu.;Tongjia Chu.;Huan Liu.;Jian Zhang.;Feng Wei.
来源: Gut. 2026年
Vasculogenic mimicry (VM) is a non-endothelial vascularisation programme sustaining pancreatic ductal adenocarcinoma (PDAC) perfusion and metastasis, yet its regulators and therapeutic vulnerabilities remain unclear.
18. Token-guided multimodal prognosis in hepatocellular carcinoma: a framework steered by tumour-stroma ratio.
作者: He-Yu Huang.;Kun Wu.;Li-Mei Qu.;Xiao-Dong Sun.;Ming-Yue Li.;Feng Wei.;Ping Zhang.;Alfred Wei Chieh Kow.;Yu-Guo Chen.;Mei-Shan Jin.;Liang Guo.;Wei Qiu.;Meng Wang.;Xiao-Ju Shi.;Jun-Feng Ye.;Chuan-Hao Hu.;Yue-Xuan Zhao.;Yu Huang.;Zhong-Qi Fan.;Yu-Shan Zheng.;Feng-Ying Xie.;Guo-Yue Lv.
来源: Gut. 2026年
The tumour-stroma ratio (TSR) is a potential prognostic indicator, yet hindered by quantification challenges and conflicting reports.
|