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1. Rice-derived recombinant human serum albumin as an alternative to human plasma for patients with decompensated liver cirrhosis: a randomised, double-blind, positive-controlled and non-inferiority trial.
作者: Junqi Niu.;Yanhang Gao.;Guiqiang Wang.;Zhijie Qin.;Cuisong Wu.;Zujiang Yu.;Lichun Wang.;Zhongjie Hu.;Xing Li.;Zong Zhang.;Yue Chen.;Lvfeng Yao.;Jinhui Yang.;Guang-Ming Li.;Yida Yang.;Xiaobo Lu.;Ye Gu.;Xiaofeng Wu.;Xiaorong Mao.;Zhongyin Zhou.;Jia Shang.;Bingliang Lin.;Ji-Dong Jia.;Fengmei Wang.;Jiming Zhang.;Hongyan Ma.;Xinrui Wang.;Cliff Y Yang.;Daichang Yang.
来源: Gut. 2025年74卷9期1476-1485页
Despite inadequate supply and potential contamination risk, human plasma has remained the only source for human serum albumin (pHSA) intravenous administration since the 1940s.
2. Prophylactic clip closure after endoscopic submucosal dissection of large flat and sessile colorectal polyps: a multicentre randomised controlled trial (EPOC trial).
作者: Akihiro Miyakawa.;Yuzuru Tamaru.;Takeshi Mizumoto.;Noriyoshi Kanazawa.;Shiori Uchiyama.;Kosuke Maehara.;Yorinobu Sumida.;Akira Nakamura.;Ei Itobayashi.;Haruhisa Shimura.;Yoshio Suzuki.;Tomoyuki Akita.;Kenji Shimura.;Toshio Kuwai.
来源: Gut. 2025年74卷11期1814-1820页
Prophylactic clip closure after endoscopic mucosal resection reduces delayed bleeding in large and proximal colon lesions; however, evidence regarding its effectiveness in colorectal endoscopic submucosal dissection (ESD) is lacking.
3. Cold snare endoscopic resection for large colon polyps: a randomised trial.
作者: Heiko Pohl.;Douglas K Rex.;Jeremy Barber.;Matthew T Moyer.;B Joseph Elmunzer.;Amit Rastogi.;Stuart R Gordon.;Eugene Zolotarevsky.;John M Levenick.;Harry R Aslanian.;Mazen Elatrache.;Daniel von Renteln.;Michael B Wallace.;Bhaumik Brahmbhatt.;Rajesh N Keswani.;Nikhil A Kumta.;Douglas K Pleskow.;Zachary L Smith.;Mouhanna K Abu Ghanimeh.;Stephen Simmer.;Omid Sanaei.;Todd A Mackenzie.;Cyrus Piraka.
来源: Gut. 2025年74卷11期1804-1813页
Complications of endoscopic mucosal resection (EMR) of large colorectal polyps remain a concern.
4. Prevention of rebleeding after primary haemostasis using haemostatic powder in non-variceal upper gastrointestinal bleeding: a multicentre randomised controlled trial.
作者: Jongbeom Shin.;Boram Cha.;Jitaek Hong.;Kye Sook Kwon.;Eunhye Lee.;Jin Hee Maeng.;Jun-Won Chung.;Dong Kyun Park.;Yoon Jae Kim.;Kwang An Kwon.;Jung Ho Kim.;Kwang-Suk Seo.;Su Jin Hong.;Kyoung Oh Kim.
来源: Gut. 2025年74卷11期1821-1827页
Non-variceal upper gastrointestinal bleeding (NVUGIB) remains a major cause of morbidity and mortality. Rebleeding rates following endoscopic treatment can reach up to 25% within 72 hours in patients with high-risk lesions.
5. Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis.
作者: Virginia Mela.;Violeta Heras.;Monika Iesmantaite.;María Luisa García-Martín.;Manuel Bernal.;Joel D Posligua-García.;Alba Subiri-Verdugo.;José Ignacio Martínez-Montoro.;Ana María Gómez-Pérez.;Borja Bandera.;Isabel Moreno-Indias.;Francisco J Tinahones.
来源: Gut. 2025年74卷11期1828-1846页
Obesity-related cognitive decline is linked to gut microbiota dysbiosis, with emerging evidence suggesting that dietary interventions may ameliorate cognitive impairment via gut-brain axis modulation. The role of microglial cells in this process remains underexplored.
6. Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial.
作者: Luming Huang.;Zhe Feng.;Wenjuan Yang.;Yin Zhu.;Jing Li.;Libin Huang.;Rui Wang.;Lan Peng.;Mingshun He.;Yingmei Tang.;Ping Chen.;Cheng Lan.;Xiaoqing Zhou.;Lin Zhou.;Cheng Ye.;Linhao Zhang.;Jingsun Jiang.;Yanting Ye.;Rui Wang.;Yan He.;Yan Liu.;Hui Gong.;Huifang Xiong.;Liang Xia.;Haiyan Xu.;Bin Zhang.;Rongfang Tu.;Chun Du.;Lujia Cui.;Jinhang Gao.;Zhiyin Huang.;Chengwei Tang.
来源: Gut. 2025年74卷9期1467-1475页
There is no effective drug treatment for the organ failure (OF) caused by severe acute pancreatitis (SAP).
7. Choice of colon capsule or colonoscopy versus default colonoscopy in FIT positive patients in the Danish screening programme: a parallel group randomised controlled trial.
作者: Gunnar Baatrup.;Thomas Bjørsum-Meyer.;Lasse Kaalby.;Benedicte Schelde-Olesen.;Morten Kobaek-Larsen.;Anastasios Koulaouzidis.;Rasmus Kroijer.;Issam Al-Najami.;Niels Buch.;Anders Høgh.;Niels Qvist.;Marianne Kirstine Thygesen.;Ulrik Deding.; .
来源: Gut. 2025年74卷10期1616-1623页
Colonoscopy is among the standard tests for colorectal cancer (CRC) screening. However, uptake varies, and alternatives such as colon capsule endoscopy (CCE) are available. The uptake and detection rate of clinically significant neoplasia with CCE, compared with colonoscopy, remain unclear in this setting.
8. Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP): a multicentre, double-blind, randomised, controlled trial.
作者: Xiaoyu Kang.;Mingxing Xia.;Jun Wang.;Xiangping Wang.;Hui Luo.;Wenhao Qin.;Zirong Liang.;Gang Zhao.;Longbao Yang.;Hao Sun.;Jie Tao.;Bo Ning.;Li Zhong.;Rongchun Zhang.;Xuyuan Ma.;Jianghai Zhao.;Laifu Yue.;Haifeng Jin.;Chenxi Kang.;Gui Ren.;Shuhui Liang.;Haiying Wang.;Ling Wang.;Yongzhan Nie.;Kaichun Wu.;Dai-Ming Fan.;Yanglin Pan.
来源: Gut. 2025年74卷7期1094-1102页
Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study was to compare the efficacy of 100 mg rectal indomethacin versus diclofenac on PEP incidences.
9. Multicentre randomised controlled trial of a self-assembling haemostatic gel to prevent delayed bleeding following endoscopic mucosal resection (PURPLE Trial).
作者: Jan Drews.;Markus Zachäus.;Tobias Kleemann.;Jörg Schirra.;Oscar Cahyadi.;Oliver Möschler.;Christian Schulze.;Ingo Steinbrück.;Edris Wedi.;Oliver Pech.;Tobias J Weismüller.;Armin Küllmer.;Mohamed Abdelhafez.;Jochen Wedemeyer.;Torsten Beyna.;Julian Riedel.;Ulrich Paul Halm.;Carola Güther.;Riccardo Vasapolli.;Christian Torres Reyes.;Daniel R Quast.;Oliver Bachmann.;Erini Dedonaki.;Jörg Ulrich.;Inna Marchuk.;Christina Frahm.;Tanja Steffen.;Peter Wohlmuth.;Torsten Bunde.;Nele Geßler.;Thomas von Hahn.
来源: Gut. 2025年74卷7期1103-1111页
Prophylactic application of a haemostatic gel to the resection field may be an easy way to prevent delayed bleeding, a frequent complication after endoscopic mucosal resection (EMR).
10. Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy - a multi-arm randomised controlled trial (HELIOS).
作者: Maarten Te Groen.;Anouk M Wijnands.;Nathan den Broeder.;Dirk J de Jong.;Willemijn A van Dop.;Marjolijn Duijvestein.;Herma H Fidder.;Fiona van Schaik.;Meike M C Hirdes.;Andrea E van der Meulen-de Jong.;P W Jeroen Maljaars.;Philip W Voorneveld.;K H Nanne de Boer.;Charlotte P Peters.;Bas Oldenburg.;Frank Hoentjen.; .
来源: Gut. 2025年74卷4期547-556页
It remains unclear if the increased colorectal neoplasia detection rate in inflammatory bowel disease (IBD) by high-definition (HD) dye-based chromoendoscopy compared with HD white-light endoscopy is due to enhanced contrast or increased inspection times. Longer withdrawal times may yield similar neoplasia detection rates as found by HD chromoendoscopy.
11. Withdrawal of antitumour necrosis factor in inflammatory bowel disease patients in remission: a randomised placebo-controlled clinical trial of GETECCU.
作者: Javier P Gisbert.;María G Donday.;Sabino Riestra.;Alfredo J Lucendo.;José-Manuel Benítez.;Mercè Navarro-Llavat.;Jesús Barrio.;Víctor J Morales-Alvarado.;Montserrat Rivero.;David Busquets.;Eduardo Leo Carnerero.;Olga Merino.;Óscar Nantes Castillejo.;Pablo Navarro.;Manuel Van Domselaar.;Ana Gutiérrez.;Inmaculada Alonso-Abreu.;Rafael Mejuto.;Luis Fernández-Salazar.;Marisa Iborra.;María Dolores Martín-Arranz.;Juan Ramón Pineda.;Manuela Josefa Sampedro.;Katja Serra Nilsson.;Abdel Bouhmidi.;Lissette Batista.;Carmen Muñoz Villafranca.;Iago Rodríguez-Lago.;Daniel Ceballos.;Iván Guerra.;Miriam Mañosa.;Ignacio Marín Jiménez.;Emilio Torrella.;Maribel Vera Mendoza.;María José Casanova.;Ruth de Francisco.;Laura Arias-González.;Sandra Marín Pedrosa.;Orlando García-Bosch.;Francisco Javier García-Alonso.;Pedro Delgado-Guillena.;María José García.;Leyanira Torrealba.;Andrea Núñez-Ortiz.;Miren Vicuña Arregui.;Marta Maia Bosca-Watts.;Isabel Blázquez.;Diana Acosta.;Ana Garre.;Montse Baldán.;Concepción Martínez.;Manuel Barreiro-de Acosta.;Eugeni Domènech.;Maria Esteve.;Valle García-Sánchez.;Pilar Nos.;Julián Panés.;María Chaparro.; .
来源: Gut. 2025年74卷3期387-396页
Primary objectives: to compare the rates of sustained clinical remission at 12 months in patients treated with antitumour necrosis factor (anti-TNF) and immunomodulators who withdraw anti-TNF treatment versus those who maintain it.
12. Top-down infliximab plus azathioprine versus azathioprine alone in patients with acute severe ulcerative colitis responsive to intravenous steroids: a parallel, open-label randomised controlled trial, the ACTIVE trial.
作者: Aurelien Amiot.;Philippe Seksik.;Antoine Meyer.;Carmen Stefanescu.;Pauline Wils.;Romain Altwegg.;Lucine Vuitton.;Laurianne Plastaras.;Adrien Nicolau.;Bruno Pereira.;Nicoals Duveau.;David Laharie.;Bassirou Mboup.;Medina Boualit.;Matthieu Allez.;Sylvie Rajca.;Elise Chanteloup.;Guillaume Bouguen.;Thomas Bazin.;Felix Goutorbe.;Nicolas Richard.;Driffa Moussata.;Eric Vicaut.;Laurent Peyrin-Biroulet.
来源: Gut. 2025年74卷2期197-205页
It is unknown which maintenance therapy is the most effective option for patients admitted for an acute severe ulcerative colitis (ASUC) episode responding to intravenous steroids.
13. Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.
作者: Victoria Wilkinson-Smith.;Mark Scott.;Alex Menys.;Lukasz Wiklendt.;Luca Marciani.;David Atkinson.;Stefano Sansone.;Ausra Zdanaviciene.;Carol Coupland.;Charles H Knowles.;Philip Dinning.;Stuart A Taylor.;Penny Gowland.;Caroline Louise Hoad.;Maura Corsetti.;Robin C Spiller.
来源: Gut. 2024年74卷1期35-44页
Colonic motility in constipation can be assessed non-invasively using MRI.
14. Endoscopic sphincterotomy to prevent post-ERCP pancreatitis after self-expandable metal stent placement for distal malignant biliary obstruction (SPHINX): a multicentre, randomised controlled trial.
作者: Anke M Onnekink.;Myrte Gorris.;Noor Lh Bekkali.;Philip Bos.;Paul Didden.;J Enrique Dominguez-Muñoz.;Pieter Friederich.;Emo E van Halsema.;Wouter L Hazen.;Nadine C van Huijgevoort.;Akin Inderson.;Maarten Ajm Jacobs.;Jan J Koornstra.;Sjoerd Kuiken.;Bob Ch Scheffer.;Hilbert Sloterdijk.;Ellert J van Soest.;Niels G Venneman.;Rogier P Voermans.;Thomas R de Wijkerslooth.;Janneke Wonders.;Roeland Zoutendijk.;Serge Jlb Zweers.;Paul Fockens.;Robert C Verdonk.;Roy L J van Wanrooij.;Jeanin E Van Hooft.; .
来源: Gut. 2025年74卷2期246-254页
Endoscopic retrograde cholangiopancreatography (ERCP) with fully covered self-expandable metal stent (FCSEMS) placement is the preferred approach for biliary drainage in patients with suspected distal malignant biliary obstruction (MBO). However, FCSEMS placement is associated with a high risk of post-ERCP pancreatitis (PEP). Endoscopic sphincterotomy prior to FCSEMS placement may reduce PEP risk.
15. Effects of tenofovir disoproxil fumarate on intrahepatic viral burden and liver immune microenvironment in patients with chronic hepatitis B.
作者: David Z Pan.;Cameron M Soulette.;Abhishek Aggarwal.;Dong Han.;Nicholas van Buuren.;Peiwen Wu.;Becket Feierbach.;Jaw-Town Lin.;Cheng-Hao Tseng.;Chi-Yi Chen.;Bryan Downie.;Hongmei Mo.;Lauri Diehl.;Li Li.;Simon P Fletcher.;Scott Balsitis.;Ricardo Ramirez.;Vithika Suri.;Yao-Chun Hsu.
来源: Gut. 2025年74卷4期628-638页
The impact of nucleos(t)ide analogues on intrahepatic viral burden and immune microenvironment in patients with chronic hepatitis B (CHB) is not clear.
16. Long-term hepatitis B surface antigen response after finite treatment of ARC-520 or JNJ-3989.
作者: Lung Yi Mak.;Christine I Wooddell.;Oliver Lenz.;Thomas Schluep.;James Hamilton.;Heather L Davis.;Xianhua Mao.;Wai-Kay Seto.;Michael Biermer.;Man-Fung Yuen.
来源: Gut. 2025年74卷3期440-450页
RNA interference has been extensively explored in patients with chronic hepatitis B (CHB) infection. We aimed to characterise the long-term efficacy of small interfering RNA (siRNA) on hepatitis B surface antigen (HBsAg) suppression.
17. External validation of serum biomarkers predicting short-term and mid/long-term relapse in patients with Crohn's disease stopping infliximab.
作者: Nicolas Pierre.;Vân Anh Huynh-Thu.;Dominique Baiwir.;Gabriel Mazzucchelli.;Maximilien Fléron.;Lisette Trzpiot.;Gauthier Eppe.;Edwin De Pauw.;David Laharie.;Jack Satsangi.;Peter Bossuyt.;Lucine Vuitton.;Sophie Vieujean.;Jean-Frédéric Colombel.;Marie-Alice Meuwis.;Edouard Louis.; .
来源: Gut. 2024年73卷12期1965-1973页
In patients with Crohn's disease (CD) on combination therapy (infliximab and immunosuppressant) and stopping infliximab (cohort from the study of infliximab diSconTinuation in CrOhn's disease patients in stable Remission on combined therapy with Immunosuppressors (STORI)), the risk of short-term (≤6 months) and mid/long-term relapse (>6 months) was associated with distinct blood protein profiles. Our aim was to test the external validity of this finding in the SPARE cohort (A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy).
18. Combination of carvedilol with variceal band ligation in prevention of first variceal bleed in Child-Turcotte-Pugh B and C cirrhosis with high-risk oesophageal varices: the 'CAVARLY TRIAL'.
作者: Harsh Vardhan Tevethia.;Apurva Pande.;Rajan Vijayaraghavan.;Guresh Kumar.;Shiv Kumar Sarin.
来源: Gut. 2024年73卷11期1844-1853页
Beta-blockers and endoscopic variceal band ligation (VBL) have been preferred therapies for primary prophylaxis of variceal bleeding. However, the choice of therapy in patients with advanced liver disease with high-risk varices is not clear. A comparison of these therapies alone or in combination to prevent the first variceal bleed in advanced cirrhosis patients was carried out.
19. HBcrAg values may predict virological and immunological responses to pegIFN-α in NUC-suppressed HBeAg-negative chronic hepatitis B.
作者: Andrea Vecchi.;Marzia Rossi.;Camilla Tiezzi.;Paola Fisicaro.;Sara Doselli.;Elena Adelina Gabor.;Amalia Penna.;Ilaria Montali.;Camilla Ceccatelli Berti.;Valentina Reverberi.;Anna Montali.;Simon P Fletcher.;Elisabetta Degasperi.;Dana Sambarino.;Diletta Laccabue.;Floriana Facchetti.;Simona Schivazappa.;Elisabetta Loggi.;Barbara Coco.;Daniela Cavallone.;Elena Rosselli Del Turco.;Marco Massari.;Giuseppe Pedrazzi.;Gabriele Missale.;Gabriella Verucchi.;Pietro Andreone.;Maurizia Rossana Brunetto.;Pietro Lampertico.;Carlo Ferrari.;Carolina Boni.
来源: Gut. 2024年73卷10期1737-1748页
Selected populations of patients with chronic hepatitis B (CHB) may benefit from a combined use of pegylated interferon-alpha (pegIFN-α) and nucleos(t)ides (NUCs). The aim of our study was to assess the immunomodulatory effect of pegIFN-α on T and natural killer (NK) cell responses in NUC-suppressed patients to identify cellular and/or serological parameters to predict better T cell-restoring effect and better control of infection in response to pegIFN-α for a tailored application of IFN-α add-on.
20. Cold versus hot snare endoscopic mucosal resection for large (≥15 mm) flat non-pedunculated colorectal polyps: a randomised controlled trial.
作者: Timothy O'Sullivan.;Oliver Cronin.;W Arnout van Hattem.;Francesco Vito Mandarino.;Julia L Gauci.;Clarence Kerrison.;Anthony Whitfield.;Sunil Gupta.;Eric Lee.;Stephen J Williams.;Nicholas Burgess.;Michael J Bourke.
来源: Gut. 2024年73卷11期1823-1830页
Conventional hot snare endoscopic mucosal resection (H-EMR) is effective for the management of large (≥20 mm) non-pedunculated colon polyps (LNPCPs) however, electrocautery-related complications may incur significant morbidity. With a superior safety profile, cold snare EMR (C-EMR) of LNPCPs is an attractive alternative however evidence is lacking. We conducted a randomised trial to compare the efficacy and safety of C-EMR to H-EMR.
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