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1. The value of platelet-associated parameters as biomarkers in evaluating the disease activity of inflammatory bowel disease: a systematic review and meta-analysis.
作者: Haojie Wang.;Rongrong Shao.;Sa Wu.;Yichen Zhu.;Zijun Zhang.;Mengting Cui.;Manman Xiang.;Shanshan Li.;Fangtian Fan.;Xian Li.;Yu Tao.
来源: BMC Gastroenterol. 2026年26卷1期104页
Developing inflammatory bowel disease (IBD) affects platelet counts (PLT), which are involved in blood coagulation. However, the predictive or diagnostic utility of platelet characteristics in assessing IBD disease activity of inflammatory bowel disease. We conducted thisremains unknown. This meta-analysis was conducted to quantitatively evaluate changes in platelet parameters during the active phase of IBD using a large sample size.
2. Efficacy of laparoscopic barbed sutures in the repair of gastroduodenal perforations: a meta-analysis.
作者: Qin Sun.;Junyi Lou.;Jiaxin Wan.;Yifan Yan.;Junjie Cao.;Junxian Gu.;Dan Yang.;Yueshan Pang.;Zining Luo.;Yixing Ren.;Jiebin Xie.
来源: BMC Gastroenterol. 2026年26卷1期98页
Laparoscopic repair of gastroduodenal perforation has been widely used in clinical practice. With the advent of barbed sutures, the position of traditional absorbable sutures has been challenged, but the superiority of one over the other in terms of clinical outcomes remains unclear.
3. mRNA expression of NLRP3 and IL1B in inflammatory bowel diseases: a systematic review and meta-analysis.
作者: Paula I Metselaar.;Roos C H Schilder.;Aletta D Kraneveld.;Anje A Te Velde.;Andrew Y F Li Yim.
来源: BMC Gastroenterol. 2025年26卷1期86页
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract. Clinical studies of IBD robustly show elevated interleukin 1β (IL-1β) levels in intestinal tissue, implicating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, which controls IL-1β secretion in myeloid cells. In this study, we aimed to ground potential NLRP3 involvement in IBD in molecular evidence from human studies.
4. Relationship of D-dimer with survival and metastasis in gastric cancer patients: a meta-analysis and systematic review.
作者: Xiaofei Cheng.;Yang Zhang.;Xingyuan Li.;Zhenning Xu.;Yaolin Chen.
来源: BMC Gastroenterol. 2025年26卷1期30页
D-dimer predicts survival in patients with digestive cancers. However, comprehensive analysis focused on gastric cancer patients is lacking. This meta-analysis aimed to investigate the association of D-dimer with survival in gastric cancer patients.
5. Comparative efficacy of different diet modalities on metabolic profiles and liver functions in metabolic dysfunction-associated fatty liver disease: a network meta-analysis.
作者: Jiahui Zou.;Fei Tian.;Shuqing Cui.;Jing Hou.;Zhenhua Li.;Yaochen Wei.;Haozhe Cui.;Yunpeng Li.;Shuanghao Zhou.;Zechao He.;Xiangming Ma.
来源: BMC Gastroenterol. 2025年26卷1期25页
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a global public health challenge that is primarily managed through lifestyle interventions, particularly diet. This network meta-analysis aimed to thoroughly evaluate the effectiveness of four different dietary patterns: Mediterranean diet (MD), intermittent fasting (IF), Dietary Approaches to Stop Hypertension (DASH), and low-fat diet (LF) in improving liver function and metabolic profiles in adults diagnosed with MAFLD.
6. Efficacy of pharmacotherapies on pediatric patients with metabolic dysfunction-associated steatotic liver disease: a systematic review and network meta-analysis.
作者: Shehab Yaser.;Hatem Yaser.;Hazem E Mohammed.;Mohamed Nasser.;Mohamed Khalafalla Darwish.;Mohamed E Haseeb.;Anas Hussein Heiba.;Mohamed Mabrouk Ghonaim.;Heba Aboeldahab.;Zeyad Bady.
来源: BMC Gastroenterol. 2025年25卷1期853页
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects children and is increasingly prevalent alongside rising childhood obesity. The MASLD spectrum spans from simple hepatic steatosis to metabolic-associated steatohepatitis (MASH), fibrosis, and cirrhosis. Despite this rising prevalence, the optimal pharmacotherapy for pediatric MASLD remains uncertain.
7. Effects of exercise interventions on metabolic and hepatic function markers in overweight or obese patients with MASLD: a systematic review and meta-analysis.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition strongly associated with overweight or obesity, often accompanied by dyslipidemia, insulin resistance, and elevated liver enzymes. Exercise is recommended as a first-line lifestyle intervention, but evidence on the effects of different modalities, frequencies, and durations on metabolic and hepatic markers remains inconsistent. This study conducted a systematic review and meta-analysis to quantify overall effects and compare intervention strategies.
8. Optimal dosing of ciprofol for gastrointestinal endoscopy: a systematic review and network meta-analysis.
The use of ciprofol for endoscopic sedation is relatively recent; however, no definitive conclusions have been drawn regarding its optimal dose. This study evaluated the optimal ciprofol dose for sedated endoscopy using a network meta-analysis.
9. Diagnostic value of Gd-EOB-DTPA-enhanced MRI versus contrast-enhanced CT for detecting liver metastasis in colorectal cancer: a systematic review and meta-analysis.
作者: Shuting Chen.;Min Wen.;Fangbiao Lv.;Lifen Yan.;Xiangtian Zhao.;Changhong Liang.
来源: BMC Gastroenterol. 2025年25卷1期888页
To compare the diagnostic accuracy of gadoxetate disodium enhanced MRI (EOB-MRI) and contrast-enhanced CT (CE-CT) in the detection of colorectal cancer liver metastases (CRLM).
10. Long-term prognostic value of postoperative C-reactive protein in gastric cancer patients: a systematic review and meta-analysis.
作者: Dong Yang Shen.;Zhi Yong Li.;Wen Bo Xia.;Dan Li.;Shuai Zhao.;Xu Yang.;Yun Ning Huang.
来源: BMC Gastroenterol. 2025年25卷1期887页
C-reactive protein (CRP) has begun to be used in clinical practice to predict the prognosis of cancer patients, but evidence on its prognostic role remains inconsistent. We performed a systematic review and meta-analysis to investigate the prognostic value of postoperative CRP among patients with gastric cancer.
11. Prognostic value of the platelet-to-lymphocyte ratio in colorectal cancer patients undergoing chemotherapy: a systematic review and meta-analysis.
作者: Hongmei Yu.;Youfu He.;Tingting Lv.;Xiaofeng Lu.;Yan Shu.;Hongying Pan.
来源: BMC Gastroenterol. 2025年25卷1期834页
This research aimed to estimate the prognostic value of the platelet-to-lymphocyte ratio (PLR) in colorectal cancer (CRC) patients receiving chemotherapy.
12. Efficacy of GLP-1 receptor agonists on obesity and metabolic profile in patients with inflammatory bowel disease: a systematic review and meta-analysis.
作者: Fatemeh Ojaghi Shirmard.;Seyed Morteza Pourfaraji.;Mahyaar Omouri-Kharashtomi.;Arash Amani.
来源: BMC Gastroenterol. 2025年25卷1期878页
Previous studies have shown an increase in obesity prevalence in the inflammatory bowel disease (IBD) population. The popularity of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) has increased in recent years due to their effectiveness in weight management. In this comprehensive review, we evaluate the efficacy of GLP-1 RAs in the management of obesity in patients with IBD.
13. Comprehensive assessment beyond eosinophils in eosinophilic esophagitis: an updated network meta-analysis.
作者: Yangbao Lyu.;Zhi Wu.;Yuming Zhou.;Yue Zhang.;Shuliang Zhao.
来源: BMC Gastroenterol. 2025年25卷1期877页
The rapid development of therapies for eosinophilic esophagitis (EoE), particularly involving biologics and small molecules, has prompted questions about their roles within current treatment algorithms. We aimed to examine the relative efficacy of novel biologics, small molecules and topical steroids by evaluating clinical, endoscopic, and histological improvements.
14. Gamma-glutamyltransferase and the survival of hepatocellular carcinoma patients after transarterial chemoembolization: a meta‑analysis and systematic review.
作者: Zixin Huang.;Manli Zhou.;Sisi Feng.;Xiaomin Xiao.;Baiyun Zhong.
来源: BMC Gastroenterol. 2025年25卷1期802页
Plentiful studies have reported that preoperative gamma-glutamyltransferase (GGT) had a strong relationship with the prognosis of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). Nevertheless, due to the small sample size and contradictory conclusions, the predictive function remains indefinite. To investigate the relationship between pretreatment GGT value and clinical outcomes in HCC patients undergoing TACE, a meta-analysis including 10 articles was constructed.
15. The effect of intravenous anesthesia on postoperative cognitive function in patients undergoing painless gastroscopy: a meta-analysis.
作者: Zhen Jia.;Yubai Leng.;Yetie Fan.;Wanwan Ji.;Bin Zhou.;Zhiming Tan.
来源: BMC Gastroenterol. 2025年25卷1期803页
With the development of comfortable medical care, the application of intravenous anesthesia in painless gastroscopy is becoming increasingly widespread. However, anesthetic drugs may have adverse effects on postoperative cognitive function, and the risk of postoperative cognitive dysfunction (POCD) is particularly worthy of attention in the elderly population. Our aim is to evaluate the effect of intravenous anesthesia on postoperative cognitive function (POCF) in patients undergoing painless gastroscopy, with a focus on identifying potential risks of POCD and guiding clinical anesthesia practices.
16. Risk factors for incomplete excision of colorectal polyps: a systematic review and meta-analysis.
作者: Zhongxin Sun.;Tengfei Cao.;Wen Wei.;Jiao Li.;Jing Shan.;Weidong Xi.;Xiaobin Sun.
来源: BMC Gastroenterol. 2025年25卷1期796页
The object of this study was to explore the risk factors for incomplete excision of colorectal polyps (CP) through a systematic review and meta-analysis.
17. Effects of enhanced recovery after surgery nursing on patients undergoing laparoscopic colectomy: a systematic review and meta-analysis.
This study aimed to systematically evaluate the effects of Enhanced Recovery After Surgery (ERAS) nursing protocols on patients undergoing laparoscopic colectomy.
18. Efficacy of N-Acetylcysteine in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and meta-analysis.
作者: Ahmad Hormati.;Asma Mousavi.;Shayan Shojaei.;Atie Moghtadaei.;Sanaz Bordbar.;Hediyeh Alemi.;Amir Kasaeian.;Sadaf Sepanlou.
来源: BMC Gastroenterol. 2025年25卷1期783页
Endoscopic retrograde cholangiopancreatography (ERCP) is a widely utilized procedure for diagnosing and treating biliary and pancreatic disorders. However, it carries a risk of post-ERCP pancreatitis (PEP). N-Acetylcysteine (NAC) has been proposed as a potential prophylactic agent due to its antioxidant properties, yet its efficacy remains debated. This systematic review and meta-analysis aimed to evaluate the effectiveness of NAC in preventing PEP in patients undergoing ERCP.
19. Risk prediction models for lymph node metastasis in early gastric cancer patients: a systematic review and meta-analysis.
作者: Meng Duan.;Min Li.;Lei He.;Shiming Dai.;Lang Zhou.;Zhiqun Liu.;Jie Yang.;Lingyuan Chen.;Xiang Liu.;Zhaoshu Wu.
来源: BMC Gastroenterol. 2025年25卷1期776页
The number of risk prediction models for lymph node metastasis in early gastric cancer is increasing, but the quality and applicability of these models in clinical practice and future research remain unknown.
20. Efficacy of TDF, TAF, TMF, and TDF-to-TAF switch in chronic hepatitis B: a network meta-analysis.
作者: Shuqi Yang.;Yijie Lin.;Huatang Zhang.;Yanlan Liang.;Wenjin Yuan.;Xing Wang.;Wenwu Lin.;Wencong Hong.;Zhijun Su.;Dawu Zeng.;Xueping Yu.
来源: BMC Gastroenterol. 2025年25卷1期760页
We compared the efficacy of four treatment strategies for chronic hepatitis B (CHB): tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), tenofovir amibufenamide (TMF), and TDF-to-TAF switch strategies strategy. We conducted a network meta-analysis to provide evidence-based clinical guidance.
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