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1. Pharmacologic Treatment of Acute Attacks of Episodic Migraine: A Systematic Review and Network Meta-analysis for the American College of Physicians.
作者: Gerald Gartlehner.;Andreea Dobrescu.;Gernot Wagner.;Andrea Chapman.;Emma Persad.;Claus Nowak.;Irma Klerings.;Camilla Neubauer.;Johanna Feyertag.;Arianna Gadinger.;Kylie Thaler.
来源: Ann Intern Med. 2025年178卷4期507-524页
Migraine is common, affecting 15% of Americans.
2. De-escalating Dual Antiplatelet Therapy to Ticagrelor Monotherapy in Acute Coronary Syndrome : A Systematic Review and Individual Patient Data Meta-analysis of Randomized Clinical Trials.
作者: Yong-Joon Lee.;Xiaofei Gao.;Sang-Hyup Lee.;Jing Kan.;Jun-Jie Zhang.;Seung-Jun Lee.;Sung-Jin Hong.;Chul-Min Ahn.;Jung-Sun Kim.;Byeong-Keuk Kim.;Young-Guk Ko.;Donghoon Choi.;Yangsoo Jang.;Gregg W Stone.;Shao-Liang Chen.;Myeong-Ki Hong.
来源: Ann Intern Med. 2025年178卷4期533-542页
The role of transitioning from short dual antiplatelet therapy (DAPT) to potent P2Y12 inhibitor monotherapy in patients with acute coronary syndrome (ACS) undergoing drug-eluting stent (DES) implantation remains inconclusive.
3. Bleeding Risks With Non-Vitamin K Oral Anticoagulants Versus Single Antiplatelet Therapy : A Systematic Review and Meta-analysis of Randomized Trials.
作者: Michael Ke Wang.;Geethan Baskaran.;Ghazal Razeghi.;Richard Ma.;Louis S Park.;Manasi Tannu.;P J Devereaux.;William F McIntyre.;Jeff S Healey.;Ashkan Shoamanesh.;David Conen.
来源: Ann Intern Med. 2025年178卷3期360-368页
In several settings, therapeutic-dose non-vitamin K oral anticoagulants (NOACs) are superior to aspirin for the prevention of arterial and venous thromboembolism.
4. Comparative Effectiveness of Pharmacologic Treatments for the Prevention of Episodic Migraine Headache: A Systematic Review and Network Meta-analysis for the American College of Physicians.
作者: Johanna A A Damen.;Bada Yang.;Demy L Idema.;Robin W M Vernooij.;Linde Huis In 't Veld.;Mike Kusters.;Rene Spijker.;Kim van der Braak.;Pauline Heus.;Kevin Jenniskens.;Lotty Hooft.
来源: Ann Intern Med. 2025年178卷3期369-380页
Various treatments for preventing episodic migraine are available.
5. Effectiveness of Synchronous Postdischarge Contacts on Health Care Use and Patient Satisfaction : A Systematic Review and Meta-analysis.
作者: Joel C Boggan.;Spoorthi Sankineni.;Paul A Dennis.;Dazhe Chen.;Tina Wong Sledge.;David Halpern.;Sharron Rushton.;John W Williams.;Tatyana Der.;Amir Alishahi Tabriz.;Adelaide M Gordon.;Morgan Jacobs.;Nathan A Boucher.;Maria Colandrea.;Anastasia-Stefania Alexopoulos.;Joanne Roman Jones.;Nina Leflore-Lloyd.;Sarah Cantrell.;Karen M Goldstein.;Jennifer M Gierisch.
来源: Ann Intern Med. 2025年178卷2期229-240页
Postdischarge contacts (PDCs) after hospitalization are common practice, but their effectiveness in reducing use of acute care after discharge remains unclear.
6. Anticoagulation Among Patients Hospitalized for COVID-19 : A Systematic Review and Prospective Meta-analysis.
作者: .;Claire L Vale.;Peter J Godolphin.;David J Fisher.;Julian P T Higgins.;Alexandra McAleenan.;Francesca Spiga.;Tobias Tritschler.;Pedro Gabriel Melo de Barros E Silva.;David D Berg.;Jeffrey S Berger.;Lindsay R Berry.;Behnood Bikdeli.;Marc Blondon.;Erin A Bohula.;Marco Cattaneo.;Riccardo Colombo.;Valeria Coluccio.;Maria T DeSancho.;Michael E Farkouh.;Valentin Fuster.;Massimo Girardis.;Judith S Hochman.;Thomas P Jensen.;Vivekanand Jha.;Peter Jüni.;Ajay J Kirtane.;Patrick Lawler.;Grégoire Le Gal.;Ramon Lecumberri.;Steven R Lentz.;Renato D Lopes.;Elizabeth Lorenzi.;Marco Marietta.;Carlos Henrique Miranda.;Nuccia Morici.;Susan C Morpeth.;David A Morrow.;Zoe K McQuilten.;Nuria Muñoz-Rivas.;Matthew D Neal.;Suman Pant.;Sahil A Parikh.;Usha Perepu.;Parham Sadeghipour.;Sanjum Sethi.;Michelle Sholzberg.;Alex C Spyropoulos.;Gregg W Stone.;Azita Hajhossein Talasaz.;Steven Tong.;James Totterdell.;Balasubramanian Venkatesh.;Maddalena Alessandra Wu.;Ryan Zarychanski.;Stephane Zuily.;Julie Viry.;Jamie Rylance.;Neill K J Adhikari.;Janet V Diaz.;John C Marshall.;Jonathan A C Sterne.;Srinivas Murthy.
来源: Ann Intern Med. 2025年178卷1期59-69页
Reported results of clinical trials assessing higher-dose anticoagulation in patients hospitalized for COVID-19 have been inconsistent.
7. Artificial Intelligence-Assisted Colonoscopy for Polyp Detection : A Systematic Review and Meta-analysis.
作者: Saeed Soleymanjahi.;Jack Huebner.;Lina Elmansy.;Niroop Rajashekar.;Nando Lüdtke.;Rumzah Paracha.;Rachel Thompson.;Alyssa A Grimshaw.;Farid Foroutan.;Shahnaz Sultan.;Dennis L Shung.
来源: Ann Intern Med. 2024年177卷12期1652-1663页
Randomized clinical trials (RCTs) of computer-aided detection (CADe) system-enhanced colonoscopy compared with conventional colonoscopy suggest increased adenoma detection rate (ADR) and decreased adenoma miss rate (AMR), but the effect on detection of advanced colorectal neoplasia (ACN) is unclear.
8. Effect of Weight Loss Interventions on the Symptomatic Burden and Biomarkers of Polycystic Ovary Syndrome : A Systematic Review of Randomized Controlled Trials.
作者: Jadine Scragg.;Alice Hobson.;Lia Willis.;Kathryn S Taylor.;Sharon Dixon.;Susan A Jebb.
来源: Ann Intern Med. 2024年177卷12期1664-1674页
Polycystic ovary syndrome (PCOS) is common in women of reproductive age and is associated with obesity. Clinical guidelines recommend weight loss, but the impact on the clinical manifestations of PCOS is unclear.
9. Update Alert 2: Nonpharmacologic and Pharmacologic Treatments of Adult Patients With Major Depressive Disorder: A Systematic Review and Network Meta-Analysis for a Clinical Guideline by the American College of Physicians.
作者: Andreea Iulia Dobrescu.;Emma Persad.;Irma Klerings.;Gerald Gartlehner.
来源: Ann Intern Med. 2024年177卷8期e2400428页 10. Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers for Advanced Chronic Kidney Disease : A Systematic Review and Retrospective Individual Participant-Level Meta-analysis of Clinical Trials.
作者: Elaine Ku.;Lesley A Inker.;Hocine Tighiouart.;Charles E McCulloch.;Ogechi M Adingwupu.;Tom Greene.;Raymond O Estacio.;Mark Woodward.;Dick de Zeeuw.;Julia B Lewis.;Thierry Hannedouche.;Tazeen H Jafar.;Enyu Imai.;Giuseppe Remuzzi.;Hiddo J L Heerspink.;Fan Fan Hou.;Robert D Toto.;Philip K Li.;Mark J Sarnak.
来源: Ann Intern Med. 2024年177卷7期953-963页
In patients with advanced chronic kidney disease (CKD), the effects of initiating treatment with an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin-receptor blocker (ARB) on the risk for kidney failure with replacement therapy (KFRT) and death remain unclear.
11. Computer-Aided Diagnosis for Leaving Colorectal Polyps In Situ : A Systematic Review and Meta-analysis.
作者: Cesare Hassan.;Masashi Misawa.;Tommy Rizkala.;Yuichi Mori.;Shahnaz Sultan.;Antonio Facciorusso.;Giulio Antonelli.;Marco Spadaccini.;Britt B S L Houwen.;Emanuele Rondonotti.;Harsh Patel.;Kareem Khalaf.;James Weiquan Li.;Gloria M Fernandez.;Pradeep Bhandari.;Evelien Dekker.;Seth Gross.;Tyler Berzin.;Per Olav Vandvik.;Loredana Correale.;Shin-Ei Kudo.;Prateek Sharma.;Douglas K Rex.;Alessandro Repici.;Farid Foroutan.; .
来源: Ann Intern Med. 2024年177卷7期919-928页
Computer-aided diagnosis (CADx) allows prediction of polyp histology during colonoscopy, which may reduce unnecessary removal of nonneoplastic polyps. However, the potential benefits and harms of CADx are still unclear.
12. Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-analyses.
作者: Bu B Yeap.;Ross J Marriott.;Girish Dwivedi.;Robert J Adams.;Leen Antonio.;Christie M Ballantyne.;Douglas C Bauer.;Shalender Bhasin.;Mary L Biggs.;Peggy M Cawthon.;David J Couper.;Adrian S Dobs.;Leon Flicker.;David J Handelsman.;Graeme J Hankey.;Anke Hannemann.;Robin Haring.;Benjumin Hsu.;Sean A Martin.;Alvin M Matsumoto.;Dan Mellström.;Claes Ohlsson.;Terence W O'Neill.;Eric S Orwoll.;Matteo Quartagno.;Molly M Shores.;Antje Steveling.;Åsa Tivesten.;Thomas G Travison.;Dirk Vanderschueren.;Gary A Wittert.;Frederick C W Wu.;Kevin Murray.
来源: Ann Intern Med. 2024年177卷6期768-781页
Whether circulating sex hormones modulate mortality and cardiovascular disease (CVD) risk in aging men is controversial.
13. Update Alert: Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.14. The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis.
作者: Renata Iskander.;Hannah Moyer.;Dean Fergusson.;Sean McGrath.;Andrea Benedetti.;Jonathan Kimmelman.
来源: Ann Intern Med. 2024年177卷6期759-767页
Many patients participate in cancer trials to access new therapies. The extent to which new treatments produce clinical benefit for trial participants is unclear.
15. Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Systematic Review and Network Meta-analysis for the American College of Physicians.
作者: Tyler Drake.;Adrienne Landsteiner.;Lisa Langsetmo.;Roderick MacDonald.;Maylen Anthony.;Caleb Kalinowski.;Kristen Ullman.;Charles J Billington.;Anjum Kaka.;Shahnaz Sultan.;Timothy J Wilt.
来源: Ann Intern Med. 2024年177卷5期618-632页
Newer diabetes medications may have beneficial effects on mortality, cardiovascular outcomes, and renal outcomes.
16. Long-Term Effect of Salt Substitution for Cardiovascular Outcomes : A Systematic Review and Meta-analysis.
作者: Hannah Greenwood.;Katelyn Barnes.;Justin Clark.;Lauren Ball.;Loai Albarqouni.
来源: Ann Intern Med. 2024年177卷5期643-655页
Salt substitution is a simple yet increasingly promising strategy to improve cardiovascular outcomes.
17. Development and Validation of a Protein Risk Score for Mortality in Heart Failure : A Community Cohort Study.
作者: Kayode O Kuku.;Joseph J Shearer.;Maryam Hashemian.;Rebecca Oyetoro.;Hoyoung Park.;Brittany Dulek.;Suzette J Bielinski.;Nicholas B Larson.;Peter Ganz.;Daniel Levy.;Bruce M Psaty.;Jungnam Joo.;Véronique L Roger.
来源: Ann Intern Med. 2024年177卷1期39-49页
Heart failure (HF) is a complex clinical syndrome with high mortality. Current risk stratification approaches lack precision. High-throughput proteomics could improve risk prediction. Its use in clinical practice to guide the management of patients with HF depends on validation and evidence of clinical benefit.
18. Real-Time Computer-Aided Detection of Colorectal Neoplasia During Colonoscopy : A Systematic Review and Meta-analysis.
作者: Cesare Hassan.;Marco Spadaccini.;Yuichi Mori.;Farid Foroutan.;Antonio Facciorusso.;Paraskevas Gkolfakis.;Georgios Tziatzios.;Konstantinos Triantafyllou.;Giulio Antonelli.;Kareem Khalaf.;Tommy Rizkala.;Per Olav Vandvik.;Alessandro Fugazza.;Emanuele Rondonotti.;Jeremy R Glissen-Brown.;Shunsuke Kamba.;Marcello Maida.;Loredana Correale.;Pradeep Bhandari.;Rodrigo Jover.;Prateek Sharma.;Douglas K Rex.;Alessandro Repici.
来源: Ann Intern Med. 2023年176卷9期1209-1220页
Artificial intelligence computer-aided detection (CADe) of colorectal neoplasia during colonoscopy may increase adenoma detection rates (ADRs) and reduce adenoma miss rates, but it may increase overdiagnosis and overtreatment of nonneoplastic polyps.
19. Diagnostic Strategies for the Assessment of Suspected Stable Coronary Artery Disease : A Systematic Review and Meta-analysis.
作者: Andrea Zito.;Mattia Galli.;Giuseppe Biondi-Zoccai.;Antonio Abbate.;Pamela S Douglas.;Giuseppe Princi.;Domenico D'Amario.;Cristina Aurigemma.;Enrico Romagnoli.;Carlo Trani.;Francesco Burzotta.
来源: Ann Intern Med. 2023年176卷6期817-826页
There is uncertainty about which diagnostic strategy for detecting coronary artery disease (CAD) provides better outcomes.
20. Major Update: Masks for Prevention of SARS-CoV-2 in Health Care and Community Settings-Final Update of a Living, Rapid Review.
Optimal use of masks for preventing COVID-19 is unclear.
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