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1381. Real-World Effectiveness of BNT162b2 Against Infection and Severe Diseases in Children and Adolescents.
作者: Qiong Wu.;Jiayi Tong.;Bingyu Zhang.;Dazheng Zhang.;Jiajie Chen.;Yuqing Lei.;Yiwen Lu.;Yudong Wang.;Lu Li.;Yishan Shen.;Jie Xu.;L Charles Bailey.;Jiang Bian.;Dimitri A Christakis.;Megan L Fitzgerald.;Kathryn Hirabayashi.;Ravi Jhaveri.;Alka Khaitan.;Tianchen Lyu.;Suchitra Rao.;Hanieh Razzaghi.;Hayden T Schwenk.;Fei Wang.;Margot I Gage Witvliet.;Eric J Tchetgen Tchetgen.;Jeffrey S Morris.;Christopher B Forrest.;Yong Chen.
来源: Ann Intern Med. 2024年177卷2期165-176页
The efficacy of the BNT162b2 vaccine in pediatrics was assessed by randomized trials before the Omicron variant's emergence. The long-term durability of vaccine protection in this population during the Omicron period remains limited.
1382. In ICU patients not receiving early PN, tight and liberal glucose control did not differ for length of ICU stay or death.
Gunst J, Debaveye Y, Güiza F, et al; TGC-Fast Collaborators. Tight blood-glucose control without early parenteral nutrition in the ICU. N Engl J Med. 2023;389:1180-1190. 37754283.
1383. In symptomatic AF, catheter ablation vs. medical therapy reduced depression and anxiety symptoms at 12 mo.
Al-Kaisey AM, Parameswaran R, Bryant C, et al. Atrial fibrillation catheter ablation vs medical therapy and psychological distress: a randomized clinical trial. JAMA. 2023;330:925-933. 37698564.
1384. Respectful Maternity Care : A Systematic Review.
作者: Amy G Cantor.;Rebecca M Jungbauer.;Andrea C Skelly.;Erica L Hart.;Katherine Jorda.;Cynthia Davis-O'Reilly.;Aaron B Caughey.;Ellen L Tilden.
来源: Ann Intern Med. 2024年177卷1期50-64页
Severe maternal morbidity and mortality are worse in the United States than in all similar countries, with the greatest effect on Black women. Emerging research suggests that disrespectful care during childbirth contributes to this problem.
1385. After EVT for ischemic stroke, intensive vs. conventional BP management reduced functional independence at 3 mo.
Nam HS, Kim YD, Heo J, et al; OPTIMAL-BP Trial Investigators. Intensive vs conventional blood pressure lowering after endovascular thrombectomy in acute ischemic stroke: the OPTIMAL-BP randomized clinical trial. JAMA. 2023;330:832-842. 37668619.
1386. In latent autoimmune diabetes in adults, mortality was similar to T2DM but retinopathy was higher at 5.9 y.
Wei Y, Herzog K, Ahlqvist E, et al. All-cause mortality and cardiovascular and microvascular diseases in latent autoimmune diabetes in adults. Diabetes Care. 2023;46:1857-1865. 37635682.
1387. In outpatients with COVID-19 during Omicron variant circulation, molnupiravir and nirmatrelvir-ritonavir improved outcomes.
Sommer I, Ledinger D, Thaler K, et al. Outpatient treatment of confirmed COVID-19: a living, rapid evidence review for the American College of Physicians (version 2). Ann Intern Med. 2023;176:1377-1385. 37722115.
1388. CRC screening with sigmoidoscopy extends life by 110 d; other cancer screening tests do not extend life.
Bretthauer M, Wieszczy P, Løberg M, et al. Estimated lifetime gained with cancer screening tests: a meta-analysis of randomized clinical trials. JAMA Intern Med. 2023;183:1196-1203. 37639247.
1390. In noncardiac thoracic surgery, low-dose colchicine did not reduce AF or myocardial injury after noncardiac surgery at 14 d.
Conen D, Ke Wang M, Popova E, et al; COP-AF Investigators. Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial. Lancet. 2023;402:1627-1635. 37640035.
1391. Rates of Downstream Procedures and Complications Associated With Lung Cancer Screening in Routine Clinical Practice : A Retrospective Cohort Study.
作者: Katharine A Rendle.;Chelsea A Saia.;Anil Vachani.;Andrea N Burnett-Hartman.;V Paul Doria-Rose.;Sarah Beucker.;Christine Neslund-Dudas.;Caryn Oshiro.;Roger Y Kim.;Jennifer Elston-Lafata.;Stacey A Honda.;Debra Ritzwoller.;Jocelyn V Wainwright.;Nandita Mitra.;Robert T Greenlee.
来源: Ann Intern Med. 2024年177卷1期18-28页
Lung cancer screening (LCS) using low-dose computed tomography (LDCT) reduces lung cancer mortality but can lead to downstream procedures, complications, and other potential harms. Estimates of these events outside NLST (National Lung Screening Trial) have been variable and lacked evaluation by screening result, which allows more direct comparison with trials.
1392. In medical inpatients, the IMPROVE risk score had moderate predictive power for 14-d in-hospital bleeding.
Villiger R, Juillard P, Darbellay Farhoumand P, et al. Prediction of in-hospital bleeding in acutely ill medical patients: external validation of the IMPROVE bleeding risk score. Thromb Res. 2023;230:37-44. 37634309.
1393. In T2DM requiring insulin initiation, icodec titrated with an app safely reduced HbA1c vs. daily basal insulin analogues at 52 wk.
Bajaj HS, Aberle J, Davies M, et al. Once-weekly insulin icodec with dosing guide app versus once-daily basal insulin analogues in insulin-naive type 2 diabetes (ONWARDS 5): a randomized trial. Ann Intern Med. 2023;176:1476-1485. 37748181.
1394. Development and Validation of a Protein Risk Score for Mortality in Heart Failure : A Community Cohort Study.
作者: Kayode O Kuku.;Joseph J Shearer.;Maryam Hashemian.;Rebecca Oyetoro.;Hoyoung Park.;Brittany Dulek.;Suzette J Bielinski.;Nicholas B Larson.;Peter Ganz.;Daniel Levy.;Bruce M Psaty.;Jungnam Joo.;Véronique L Roger.
来源: Ann Intern Med. 2024年177卷1期39-49页
Heart failure (HF) is a complex clinical syndrome with high mortality. Current risk stratification approaches lack precision. High-throughput proteomics could improve risk prediction. Its use in clinical practice to guide the management of patients with HF depends on validation and evidence of clinical benefit.
1395. In acute decompensated HF, adding acetazolamide to IV loop diuretics reduced congestion at 3 d across eGFR levels.
Meekers E, Dauw J, Martens P, et al. Renal function and decongestion with acetazolamide in acute decompensated heart failure: the ADVOR trial. Eur Heart J. 2023;44:3672-3682. 37623428.
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