当前位置: 首页 >> 检索结果
1241. Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria.
作者: A Raquel Esteves.;Mário F Munoz-Pinto.;Daniela Nunes-Costa.;Emanuel Candeias.;Diana F Silva.;João D Magalhães.;A Raquel Pereira-Santos.;I Luisa Ferreira.;Susana Alarico.;Igor Tiago.;Nuno Empadinhas.;Sandra Morais Cardoso.
来源: Gut. 2023年72卷1期73-89页
Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N-methylamino-L-alanine (BMAA) in the gut may trigger some PD cases, which is especially worrying as this toxin is present in certain foods but not routinely monitored by public health authorities.
|