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1221. Letter to the editor: vaccination against upper respiratory infections is a matter of survival in alcoholic liver disease.
作者: Timo Itzel.;Thomas Falconer.;Jimmy Daza.;Ana Roig.;Jimyung Park.;Jae Youn Cheong.;Rae Woong Park.;Isabella Wiest.;Matthias Ebert.;George Hripcsak.;Andreas Teufel.
来源: Gut. 2023年72卷1期208-209页 1225. Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation.
作者: Luz Del Carmen Martínez-Sánchez.;Phuong Anh Ngo.;Rashmita Pradhan.;Lukas-Sebastian Becker.;David Boehringer.;Despina Soteriou.;Marketa Kubankova.;Christine Schweitzer.;Tatyana Koch.;Veronika Thonn.;Lena Erkert.;Iris Stolzer.;Claudia Günther.;Christoph Becker.;Benno Weigmann.;Monika Klewer.;Christoph Daniel.;Kerstin Amann.;Stefan Tenzer.;Raja Atreya.;Martin Bergo.;Cord Brakebusch.;Alastair J M Watson.;Jochen Guck.;Ben Fabry.;Imke Atreya.;Markus F Neurath.;Rocío López-Posadas.
来源: Gut. 2023年72卷2期275-294页
Increased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising the barrier function. Here, we investigated the role of live cell extrusion in epithelial barrier alterations in IBD.
1226. Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification.
作者: Carla Montironi.;Florian Castet.;Philipp K Haber.;Roser Pinyol.;Miguel Torres-Martin.;Laura Torrens.;Agavni Mesropian.;Huan Wang.;Marc Puigvehi.;Miho Maeda.;Wei Qiang Leow.;Elizabeth Harrod.;Patricia Taik.;Jigjidsuren Chinburen.;Erdenebileg Taivanbaatar.;Enkhbold Chinbold.;Manel Solé Arqués.;Michael Donovan.;Swan Thung.;Jaclyn Neely.;Vincenzo Mazzaferro.;Jeffrey Anderson.;Sasan Roayaie.;Myron Schwartz.;Augusto Villanueva.;Scott L Friedman.;Andrew Uzilov.;Daniela Sia.;Josep M Llovet.
来源: Gut. 2023年72卷1期129-140页
We previously reported a characterisation of the hepatocellular carcinoma (HCC) immune contexture and described an immune-specific class. We now aim to further delineate the immunogenomic classification of HCC to incorporate features that explain responses/resistance to immunotherapy.
1231. Epidemiological trends and trajectories of MAFLD-associated hepatocellular carcinoma 2002-2033: the ITA.LI.CA database.
作者: Alessandro Vitale.;Gianluca Svegliati-Baroni.;Alessio Ortolani.;Monica Cucco.;Giulio V Dalla Riva.;Edoardo G Giannini.;Fabio Piscaglia.;Gianludovico Rapaccini.;Mariella Di Marco.;Eugenio Caturelli.;Marco Zoli.;Rodolfo Sacco.;Giuseppe Cabibbo.;Fabio Marra.;Andrea Mega.;Filomena Morisco.;Antonio Gasbarrini.;Francesco Giuseppe Foschi.;Gabriele Missale.;Alberto Masotto.;Gerardo Nardone.;Giovanni Raimondo.;Francesco Azzaroli.;Gianpaolo Vidili.;Filippo Oliveri.;Filippo Pelizzaro.;Rafael Ramirez Morales.;Umberto Cillo.;Franco Trevisani.;Luca Miele.;Giulio Marchesini.;Fabio Farinati.; .
来源: Gut. 2023年72卷1期141-152页
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a new inclusive definition of the whole spectrum of liver diseases associated to metabolic disorders. The main objective of this study was to compare patients with MAFLD and non-MAFLD with hepatocellular carcinoma (HCC) included in a nationally representative cohort.
1233. Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria.
作者: A Raquel Esteves.;Mário F Munoz-Pinto.;Daniela Nunes-Costa.;Emanuel Candeias.;Diana F Silva.;João D Magalhães.;A Raquel Pereira-Santos.;I Luisa Ferreira.;Susana Alarico.;Igor Tiago.;Nuno Empadinhas.;Sandra Morais Cardoso.
来源: Gut. 2023年72卷1期73-89页
Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N-methylamino-L-alanine (BMAA) in the gut may trigger some PD cases, which is especially worrying as this toxin is present in certain foods but not routinely monitored by public health authorities.
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