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1201. In older patients with AF and frailty, switching from VKA to NOAC therapy increased a composite of major or CRNM bleeding at 12 mo.
Joosten LP, van Doorn S, van de Ven PM, et al. Safety of switching from a vitamin K antagonist to a non-vitamin K antagonist oral anticoagulant in frail older patients with atrial fibrillation: results of the FRAIL-AF randomized controlled trial. Circulation. 2024;149:279-289. 37634130.
1202. In AF, CHA2DS2-VASc 1 subgroups did not differ for predicting risk for arterial thromboembolism at 1 y.
Østergaard L, Olesen JB, Petersen JK, et al. Arterial thromboembolism in patients with atrial fibrillation and CHA2DS2-VASc 1: a nationwide study. Circulation. 2024;149:764-773. 38152890.
1203. Reversal of Intestinal Failure With Teduglutide in PERCC1-Associated Enteropathy: A Case Report.
作者: Emily Stenke.;Cara Dunne.;Anthea Bryce-Smyth.;Michelle Hurley.;Ben Pode-Shakked.;Yair Anikster.;Tricia Tan.;Anna Kowalka.;Paul Bech.;Billy Bourke.
来源: Ann Intern Med. 2024年177卷8期1141-1144页 1204. In community-acquired pneumonia, adding oral clarithromycin to standard care increased early clinical response.
Giamarellos-Bourboulis EJ, Siampanos A, Bolanou A, et al. Clarithromycin for early anti-inflammatory responses in community-acquired pneumonia in Greece (ACCESS): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2024;12:294-304. 38184008.
1205. New use of thiazide diuretics vs. nonthiazide antihypertensive drugs was linked to hyponatremia over 2 y.
Andersson NW, Wohlfahrt J, Feenstra B, et al. Cumulative incidence of thiazide-induced hyponatremia: a population-based cohort study. Ann Intern Med. 2024;177:1-11. 38109740.
1206. Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians (Version 1, Update Alert).
作者: Amir Qaseem.;Lauri A Hicks.;Itziar Etxeandia-Ikobaltzeta.;Tatyana A Shamliyan.;Thomas G Cooney.; .;Ethan Balk.;J. Thomas Cross.;Nick Fitterman.;Jennifer S. Lin.;Michael Maroto.;Matthew C. Miller.;Adam J. Obley.;Douglas K. Owens.;Paul G. Shekelle.;Jeffrey A. Tice.;Janice E. Tufte.;Jennifer Yost.
来源: Ann Intern Med. 2024年177卷6期eL230113页 1207. In mild ischemic stroke or high-risk TIA, DAPT started ≤72 h after onset reduced new stroke and increased bleeding at 90 d.
Gao Y, Chen W, Pan Y, et al; INSPIRES Investigators. Dual antiplatelet treatment up to 72 hours after ischemic stroke. N Engl J Med. 2023;389:2413-2424. 38157499.
1209. The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis.
作者: Renata Iskander.;Hannah Moyer.;Dean Fergusson.;Sean McGrath.;Andrea Benedetti.;Jonathan Kimmelman.
来源: Ann Intern Med. 2024年177卷6期759-767页
Many patients participate in cancer trials to access new therapies. The extent to which new treatments produce clinical benefit for trial participants is unclear.
1211. The Effect of Open-Label Semaglutide on Metabolic Dysfunction-Associated Steatotic Liver Disease in People With HIV.
作者: Jordan E Lake.;Douglas W Kitch.;Amy Kantor.;Raja Muthupillai.;Karin L Klingman.;Christina Vernon.;Pablo F Belaunzaran-Zamudio.;Carl J Fichtenbaum.;Sonya Heath.;Hugo Perazzo.;Kathleen Corey.;Todd T Brown.;Alan Landay.;Fred Sattler.;Kristine M Erlandson.
来源: Ann Intern Med. 2024年177卷6期835-838页 1212. Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease.
作者: Fu-Shun Yen.;Chii-Min Hwu.;Jia-Sin Liu.;Yi-Ling Wu.;Keong Chong.;Chih-Cheng Hsu.
来源: Ann Intern Med. 2024年177卷6期693-700页
No studies have reported the long-term outcomes of initiating sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with estimated glomerular filtration rates less than 20 mL/min/1.73 m2 to predialysis.
1214. Association Between the SaFETy Score and Self-reported Firearm Violence Among Young Adults Presenting to Emergency Departments in Three Cities: A Cross-Sectional Study.
作者: Jason E Goldstick.;Patrick M Carter.;Lauren Whiteside.;M Kit Delgado.;Rebecca M Cunningham.
来源: Ann Intern Med. 2024年177卷6期831-833页 1216. Excessive Alcohol Use and Alcohol Use Disorders: A Policy Brief of the American College of Physicians.
Alcohol is used by more people in the United States than tobacco, electronic nicotine delivery systems, or illicit drugs. Several health conditions, including cancer, cardiovascular disease, and liver disease, are associated with excessive alcohol use and alcohol use disorder. Nearly 30 million people aged 12 years or older in the United States reported past-year alcohol use disorder in 2022, but-despite its prevalence-alcohol use disorder is undertreated. In this policy brief, the American College of Physicians outlines the health effects of excessive alcohol use and alcohol use disorder, calls for policy changes to increase the availability of treatment of alcohol use disorder and excessive alcohol use, and recommends alcohol-related public health interventions.
1217. Historical Redlining and Present-Day Nonsuicide Firearm Fatalities.
作者: Ayesha Dholakia.;Kendall J Burdick.;Catherine Kreatsoulas.;Michael C Monuteaux.;Jennifer Tsai.;S V Subramanian.;Eric W Fleegler.
来源: Ann Intern Med. 2024年177卷5期592-597页
Redlining began in the 1930s with the Home Owners' Loan Corporation (HOLC); this discriminatory practice limited mortgage availability and reinforced concentrated poverty that still exists today. It is important to understand the potential health implications of this federally sanctioned segregation.
1219. Effect of Health Service Area on Primary Care Physician Provision of Low-Value Cancer Screening.
作者: Kassandra Dindinger-Hill.;Joshua Horns.;Jacob Ambrose.;Jeffrey Vehawn.;Mouneeb Choudry.;Trevor C Hunt.;Jonathan Chipman.;Benjamin Haaland.;Jiaming Li.;Heidi A Hanson.;Brock O'Neil.
来源: Ann Intern Med. 2024年177卷5期583-591页
Using a health systems approach to investigate low-value care (LVC) may provide insights into structural drivers of this pervasive problem.
1220. Comparison of Hospital Mortality and Readmission Rates by Physician and Patient Sex.
作者: Atsushi Miyawaki.;Anupam B Jena.;Lisa S Rotenstein.;Yusuke Tsugawa.
来源: Ann Intern Med. 2024年177卷5期598-608页
Little is known as to whether the effects of physician sex on patients' clinical outcomes vary by patient sex.
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