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1161. Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis.
作者: Giulia Angelini.;Simona Panunzi.;Lidia Castagneto-Gissey.;Francesca Pellicanò.;Andrea De Gaetano.;Maurizio Pompili.;Laura Riccardi.;Matteo Garcovich.;Marco Raffaelli.;Luigi Ciccoritti.;Ornella Verrastro.;Maria Francesca Russo.;Fabio Maria Vecchio.;Giovanni Casella.;James Casella-Mariolo.;Luigi Papa.;Pier Luigi Marini.;Francesco Rubino.;Carel W le Roux.;Stefan Bornstein.;Geltrude Mingrone.
来源: Gut. 2023年72卷2期392-403页
Clinical diagnosis and approval of new medications for non-alcoholic steatohepatitis (NASH) require invasive liver biopsies. The aim of our study was to identify non-invasive biomarkers of NASH and/or liver fibrosis.
1162. Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities.
作者: Shamaine Wei Ting Ho.;Taotao Sheng.;Manjie Xing.;Wen Fong Ooi.;Chang Xu.;Raghav Sundar.;Kie Kyon Huang.;Zhimei Li.;Vikrant Kumar.;Kalpana Ramnarayanan.;Feng Zhu.;Supriya Srivastava.;Zul Fazreen Bin Adam Isa.;Chukwuemeka George Anene-Nzelu.;Milad Razavi-Mohseni.;Dustin Shigaki.;Haoran Ma.;Angie Lay Keng Tan.;Xuewen Ong.;Ming Hui Lee.;Su Ting Tay.;Yu Amanda Guo.;Weitai Huang.;Shang Li.;Michael A Beer.;Roger Sik Yin Foo.;Ming Teh.;Anders Jacobsen Skanderup.;Bin Tean Teh.;Patrick Tan.
来源: Gut. 2023年72卷2期226-241页
Gastric cancer (GC) comprises multiple molecular subtypes. Recent studies have highlighted mesenchymal-subtype GC (Mes-GC) as a clinically aggressive subtype with few treatment options. Combining multiple studies, we derived and applied a consensus Mes-GC classifier to define the Mes-GC enhancer landscape revealing disease vulnerabilities.
1165. Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts.
作者: Ting Li.;Yue-Tao Tan.;Yan-Xing Chen.;Xiao-Jun Zheng.;Wen Wang.;Kun Liao.;Hai-Yu Mo.;Junzhong Lin.;Wei Yang.;Hai-Long Piao.;Rui-Hua Xu.;Huai-Qiang Ju.
来源: Gut. 2023年72卷3期501-511页
Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance. Nevertheless, it remains unclear whether methionine metabolism, RNA methylation and antitumour immunity are molecularly intertwined.
1166. A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota.
作者: Zhanzhan Li.;Bing Zhang.;Ning Wang.;Zhenqiang Zuo.;Hong Wei.;Fangqing Zhao.
来源: Gut. 2023年72卷4期686-698页
The obesity epidemic and its metabolic complications continue to be a major global public health threat with limited effective treatments, especially drugs that can be taken orally. Peptides are a promising class of molecules that have gained increased interest for their applications in medicine and biotechnology. In this study, we focused on looking for peptides that can be administrated orally to treat obesity and exploring its mechanisms.
1167. Autologous T cell responses to primary human colorectal cancer spheroids are enhanced by ectonucleotidase inhibition.
作者: Julie Bonnereau.;Tristan Courau.;Nicolas Asesio.;Delphine Salfati.;Fatiha Bouhidel.;Hélène Corte.;Sarah Hamoudi.;Nassim Hammoudi.;Julie Lavolé.;Justine Vivier-Chicoteau.;Victor Chardiny.;Leon Maggiori.;Mathieu Blery.;Romain Remark.;Cécile Bonnafous.;Pierre Cattan.;Antoine Toubert.;Purnima Bhat.;Matthieu Allez.;Thomas Aparicio.;Lionel Le Bourhis.
来源: Gut. 2023年72卷4期699-709页
T cells are major effectors of the antitumoural immune response. Their activation by tumour-associated antigens can unleash their proliferation and cytotoxic functions, leading to tumour cell elimination. However, tumour-related immunosuppressive mechanisms including the overexpression of immune checkpoints like programmed cell death protein-1 (PD-1), are also engaged, promoting immune escape. Current immunotherapies targeting these pathways have demonstrated weak efficacy in colorectal cancer (CRC). It is thus crucial to find new targets for immunotherapy in this cancer type.
1168. Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.
作者: Stephan Buch.;Hamish Innes.;Philipp Ludwig Lutz.;Hans Dieter Nischalke.;Jens U Marquardt.;Janett Fischer.;Karl Heinz Weiss.;Jonas Rosendahl.;Astrid Marot.;Marcin Krawczyk.;Markus Casper.;Frank Lammert.;Florian Eyer.;Arndt Vogel.;Silke Marhenke.;Johann von Felden.;Rohini Sharma.;Stephen Rahul Atkinson.;Andrew McQuillin.;Jacob Nattermann.;Clemens Schafmayer.;Andre Franke.;Christian Strassburg.;Marcella Rietschel.;Heidi Altmann.;Stefan Sulk.;Veera Raghavan Thangapandi.;Mario Brosch.;Carolin Lackner.;Rudolf E Stauber.;Ali Canbay.;Alexander Link.;Thomas Reiberger.;Mattias Mandorfer.;Georg Semmler.;Bernhard Scheiner.;Christian Datz.;Stefano Romeo.;Stefano Ginanni Corradini.;William Lucien Irving.;Joanne R Morling.;Indra Neil Guha.;Eleanor Barnes.;M Azim Ansari.;Jocelyn Quistrebert.;Luca Valenti.;Sascha A Müller.;Marsha Yvonne Morgan.;Jean-François Dufour.;Jonel Trebicka.;Thomas Berg.;Pierre Deltenre.;Sebastian Mueller.;Jochen Hampe.;Felix Stickel.
来源: Gut. 2023年72卷2期381-391页
Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence. This study aimed to identify novel susceptibility loci for the development of HCC in people with alcohol related cirrhosis.
1170. Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients.
作者: Massimo Rugge.;Ludovica Bricca.;Stefano Guzzinati.;Diana Sacchi.;Marco Pizzi.;Edoardo Savarino.;Fabio Farinati.;Manuel Zorzi.;Matteo Fassan.;Angelo Paolo Dei Tos.;Peter Malfertheiner.;Robert M Genta.;David Y Graham.
来源: Gut. 2023年72卷1期30-38页
Autoimmune gastritis (AIG) is an immunomediated disease targeting parietal cells, eventually resulting in oxyntic-restricted atrophy. This long-term follow-up study aimed at elucidating the natural history, histological phenotype(s), and associated cancer risk of patients with AIG consistently tested H. pylori-negative (naïve H. pylori-negative subjects).
1173. Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case-control study.
作者: Pui San Tan.;Cesar Garriga.;Ashley Clift.;Weiqi Liao.;Martina Patone.;Carol Coupland.;Rachael Bashford-Rogers.;Shivan Sivakumar.;Julia Hippisley-Cox.
来源: Gut. 2023年72卷3期512-521页
Prior studies identified clinical factors associated with increased risk of pancreatic ductal adenocarcinoma (PDAC). However, little is known regarding their time-varying nature, which could inform earlier diagnosis. This study assessed temporality of body mass index (BMI), blood-based markers, comorbidities and medication use with PDAC risk .
1175. Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma.
作者: Lei Chen.;Heng Lu.;Dunfa Peng.;Long Long Cao.;Farah Ballout.;Kannappan Srirmajayam.;Zheng Chen.;Ajaz Bhat.;Timothy C Wang.;Anthony Capobianco.;Jianwen Que.;Oliver Gene McDonald.;Alexander Zaika.;Shutian Zhang.;Wael El-Rifai.
来源: Gut. 2023年72卷3期421-432页
Oesophageal adenocarcinoma (EAC) arises in the setting of Barrett's oesophagus, an intestinal metaplastic precursor lesion that can develop in patients with chronic GERD. Here, we investigated the role of acidic bile salts, the mimicry of reflux, in activation of NOTCH signaling in EAC.
1177. Hepatic events associated with sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes: a nationwide cohort study.
作者: Sungho Bea.;Han Eol Jeong.;Sohee Park.;Oriana H Y Yu.;Yoosoo Chang.;Juhee Cho.;Dong Hyun Sinn.;Young Min Cho.;Ju-Young Shin.
来源: Gut. 2023年72卷5期1020-1022页 1178. Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases.
作者: Kevin M Sullivan.;Xiuyun Jiang.;Prajna Guha.;Christopher Lausted.;Jason A Carter.;Cynthia Hsu.;Kevin P Labadie.;Karan Kohli.;Heidi L Kenerson.;Sara K Daniel.;Xiaowei Yan.;Changting Meng.;Arezou Abbasi.;Marina Chan.;Y David Seo.;James O Park.;Ian Nicholas Crispe.;Raymond S Yeung.;Teresa S Kim.;Taranjit S Gujral.;Qiang Tian.;Steven C Katz.;Venu G Pillarisetty.
来源: Gut. 2023年72卷2期325-337页
Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive cellular therapy have had limited success in patients with microsatellite stable colorectal cancer liver metastases (CRLM). We sought to evaluate the effect of interleukin 10 (IL-10) blockade on endogenous T cell and chimeric antigen receptor T (CAR-T) cell antitumour function in CRLM slice cultures.
1179. Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC.
作者: Muyiwa Awoniyi.;Jeremy Wang.;Billy Ngo.;Vik Meadows.;Jason Tam.;Amba Viswanathan.;Yunjia Lai.;Stephanie Montgomery.;Morgan Farmer.;Martin Kummen.;Louise Thingholm.;Christoph Schramm.;Corinna Bang.;Andre Franke.;Kun Lu.;Huiping Zhou.;Jasmohan S Bajaj.;Phillip B Hylemon.;Jenny Ting.;Yury V Popov.;Johannes Roksund Hov.;Heather L Francis.;Ryan Balfour Sartor.
来源: Gut. 2023年72卷4期671-685页
Conflicting microbiota data exist for primary sclerosing cholangitis (PSC) and experimental models.
1180. Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models.
作者: Yin Tong.;Priscilla S W Cheng.;Chung Sze Or.;Sarah S K Yue.;Hoi Cheong Siu.;Siu Lun Ho.;Simon Y K Law.;Wai Yin Tsui.;Dessy Chan.;Stephanie Ma.;Siu Po Lee.;Annie S Y Chan.;April S Chan.;Shui Wa Yun.;Ho Sang Hui.;Siu Tsan Yuen.;Suet Yi Leung.;Helen H N Yan.
来源: Gut. 2023年72卷2期242-255页
Cell-cell (CC) and cell-matrix (CM) adhesions are essential for epithelial cell survival, yet dissociation-induced apoptosis is frequently circumvented in malignant cells.
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