1121. Stapokibart for Severe Uncontrolled Chronic Rhinosinusitis With Nasal Polyps: The CROWNS-2 Randomized Clinical Trial.
作者: Shen Shen.;Bing Yan.;Ming Wang.;Di Wu.;Yingshi Piao.;Jun Tang.;Xiangli Yang.;Zhiwei Cao.;Jinmei Xue.;Wen Liu.;Shixi Liu.;Li Shi.;Guangke Wang.;Xicheng Song.;Yongtian Lu.;Jianjun Chen.;Luyun Jiang.;Jing Ye.;Shaoqing Yu.;Yucheng Yang.;Hongyan Fang.;Jiping Li.;Haibo Shi.;Jiangang Fan.;Hongyue Yan.;Haifei Wang.;Bo Chen.;Chengshuo Wang.;Luo Zhang.; .
来源: JAMA. 2025年334卷11期962-72页
Chronic rhinosinusitis with nasal polyps causes severe symptoms and impaired quality of life. Stapokibart is a novel monoclonal antibody that targets interleukin 4Rα.
1135. Reducing Barriers to Mental Health Care for Physicians: An Overview and Strategic Recommendations.
Mental health challenges among physicians represent a critical public health issue with profound implications for health care delivery and workforce sustainability. Despite the proven effectiveness of mental health treatment in improving outcomes, most physicians with mental health conditions do not seek help. This treatment gap is particularly concerning given that physicians experience elevated rates of burnout, depression, anxiety, and suicide risk compared with the general population, with resulting effects on physician well-being, patient care quality, and health care system stability.
1140. Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial.
作者: Nicholas A Turner.;Toshimitsu Hamasaki.;Sarah B Doernberg.;Thomas P Lodise.;Heather A King.;Varduhi Ghazaryan.;Sara E Cosgrove.;Timothy C Jenkins.;Catherine Liu.;Shrabani Sharma.;Smitha Zaharoff.;Lana Wahid.;Valerie J Renard.;Paul Cook.;Issam Raad.;Ray Hachem.;Anne-Marie Chaftari.;Matthew Sims.;Carmen DeMarco.;Loren G Miller.;Matthew W McCarthy.;Caryn G Morse.;Chris Lucasti.;Graeme N Forrest.;Kartikeya Cherabuddi.;Christopher Polk.;Tasaduq Fazili.;Mark E Rupp.;George R Thompson.;Kami Kim.;Luke Strnad.;Amanda E Schnee.;James A McKinnell.;Mayur Ramesh.;Fernanda P Silveira.;Todd P McCarty.;Todd C Lee.;Emily G McDonald.;Kristopher Paolino.;Katie Wiegand.;Alison Wall.;Todd Riccobene.;Rinal Patel.;Urania Rappo.;Scott Evans.;Henry F Chambers.;Vance G Fowler.;Thomas L Holland.; .
来源: JAMA. 2025年
Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access.
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