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961. In advanced CKD, ACEis or ARBs reduce kidney failure vs. placebo or non-RAAS inhibitors at 34 mo.
Ku E, Inker LA, Tighiouart H, et al. Angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers for advanced chronic kidney disease: a systematic review and retrospective individual participant-level meta-analysis of clinical trials. Ann Intern Med. 2024;177:953-963. 38950402.
962. Shortfalls in Follow-up Albuminuria Quantification After an Abnormal Result on a Urine Protein Dipstick Test.
作者: Yunwen Xu.;Jung-Im Shin.;Amelia Wallace.;Juan J Carrero.;Lesley A Inker.;Amrita Mukhopadhyay.;Saul B Blecker.;Leora I Horwitz.;Morgan E Grams.;Alexander R Chang.
来源: Ann Intern Med. 2024年177卷11期1593-1595页 963. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
作者: Gerard T Portela.;Jeffrey L Carson.;Sonja A Swanson.;John H Alexander.;Paul C Hébert.;Shaun G Goodman.;Philippe Gabriel Steg.;Marnie Bertolet.;Jordan B Strom.;Dean A Fergusson.;Tabassome Simon.;Harvey D White.;Howard A Cooper.;J Dawn Abbott.;Sunil V Rao.;Bernard R Chaitman.;Christopher B Fordyce.;Renato D Lopes.;Benoit Daneault.;Maria M Brooks.; .
来源: Ann Intern Med. 2024年177卷11期1489-1498页
The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain.
964. In persistent uncontrolled asthma, adding azithromycin to standard therapy increased clinical remission rates at 1 y.
Thomas D, McDonald VM, Stevens S, et al. Effect of azithromycin on asthma remission in adults with persistent uncontrolled asthma: a secondary analysis of a randomized, double-anonymized, placebo-controlled trial. Chest. 2024;166:262-270. 38431051.
965. USPSTF recommends biennial mammography for breast cancer screening in women aged 40 to 74 y.
US Preventive Services Task Force; Nicholson WK, Silverstein M, Wong JB, et al. Screening for breast cancer: US Preventive Services Task Force recommendation statement. JAMA. 2024;331:1918-1930. 38687503.
966. In ischemic stroke treated within 4.5 h, reteplase vs. alteplase increased excellent functional outcome at 90 d.
Li S, Gu HQ, Li H, et al; RAISE Investigators. Reteplase versus alteplase for acute ischemic stroke. N Engl J Med. 2024;390:2264-2273. 38884332.
967. In adults with postacute sequelae of COVID-19, nirmatrelvir-ritonavir did not improve symptoms at 10 wk.
Geng LN, Bonilla H, Hedlin H, et al. Nirmatrelvir-ritonavir and symptoms in adults with postacute sequelae of SARS-CoV-2 infection: the STOP-PASC randomized clinical trial. JAMA Intern Med. 2024;184:1024-1034. 38848477.
968. In patients receiving invasive ventilation, PPIs reduce upper GI bleeding but did not affect mortality at 90 d.
Cook D, Deane A, Lauzier F, et al; REVISE Investigators. Stress ulcer prophylaxis during invasive mechanical ventilation. N Engl J Med. 2024;391:9-20. 38875111.
969. In adults with metabolic dysfunction, the MAF-5 score predicted risk for liver fibrosis (AUC range, 0.73 to 0.81).
van Kleef LA, Francque SM, Prieto-Ortiz JE, et al. Metabolic Dysfunction-Associated Fibrosis 5 (MAF-5) score predicts liver fibrosis risk and outcome in the general population with metabolic dysfunction. Gastroenterology. 2024;167:357-367.e9. 38513745.
971. In adults with moderate-to-severe OSA and obesity, tirzepatide reduced apnea-hypopnea events vs. placebo.
Malhotra A, Grunstein RR, Fietze I, et al; SURMOUNT-OSA Investigators. Tirzepatide for the treatment of obstructive sleep apnea and obesity. N Engl J Med. 21 Jun 2024. [Epub ahead of print.] 38912654.
972. RAS blocker effects on first HF hospitalization or CV death does not differ in Black and non-Black patients with HFrEF.
Shen L, Lee MMY, Jhund PS, et al. Revisiting race and the benefit of RAS blockade in heart failure: a meta-analysis of randomized clinical trials. JAMA. 2024;331:2094-2104. 38809561.
973. Effectiveness of Integrating Suicide Care in Primary Care : Secondary Analysis of a Stepped-Wedge, Cluster Randomized Implementation Trial.
作者: Julie Angerhofer Richards.;Maricela Cruz.;Christine Stewart.;Amy K Lee.;Taylor C Ryan.;Brian K Ahmedani.;Gregory E Simon.
来源: Ann Intern Med. 2024年177卷11期1471-1481页
Primary care encounters are common among patients at risk for suicide.
976. In adults with hypertension and high CV risk, intensive vs. standard BP-lowering therapy reduced major vascular events.
Liu J, Li Y, Ge J, et al; ESPRIT Collaborative Group. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial. Lancet. 2024;404:245-255. 38945140.
977. National Institutes of Health COVID-19 Treatment Guidelines Panel: Perspectives and Lessons Learned.
作者: Roy M Gulick.;Alice K Pau.;Eric Daar.;Laura Evans.;Rajesh T Gandhi.;Pablo Tebas.;Renée Ridzon.;Henry Masur.;H Clifford Lane.; .;Adaora A Adimora.;Jason Baker.;Lisa Baumann Kreuziger.;Roger Bedimo.;Pamela Belperio.;Anoopindar Bhalla.;Timothy Burgess.;Danielle Campbell.;Stephen Cantrill.;Kara Chew.;Kathleen Chiotos.;Craig Coopersmith.;Richard Davey.;Amy Dzierba.;Derek Eisnor.;Gregory Eschenauer.;Joseph Francis.;John Gallagher.;David Glidden.;Neil Goldenberg.;Birgit Grund.;Alison Han.;Erica Hardy.;Carly Harrison.;Lauren Henderson.;Elizabeth Higgs.;Carl Hinkson.;Brenna Hughes.;Steven Johnson.;Marla Keller.;Arthur Kim.;Richard Knight.;Safia Kuriakose.;Jeffrey Lennox.;Andrea Lerner.;Mitchell Levy.;Jonathan Li.;Christine MacBrayne.;Greg Martin.;Nandita Nadig.;Martha Nason.;Pragna Patel.;Andrew Pavia.;Michael Proschan.;Grant Schulert.;Nitin Seam.;Virginia Sheikh.;Steven Simpson.;Kanal Singh.;Susan Swindells.;Phyllis Tien.;Timothy Uyeki.;Alpana Waghmare.;Cameron Wolfe.;Jinoos Yazdany.;Judith Aberg.
来源: Ann Intern Med. 2024年177卷11期1547-1557页
In March 2020, the White House Coronavirus Task Force determined that clinicians in the United States needed expert treatment guidelines to optimally manage patients with COVID-19, a potentially life-threatening disease caused by a new pathogen for which no specific treatments were known to be effective.
978. Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.
作者: Emily N C Manoogian.;Michael J Wilkinson.;Monica O'Neal.;Kyla Laing.;Justina Nguyen.;David Van.;Ashley Rosander.;Aryana Pazargadi.;Nikko R Gutierrez.;Jason G Fleischer.;Shahrokh Golshan.;Satchidananda Panda.;Pam R Taub.
来源: Ann Intern Med. 2024年177卷11期1462-1470页
Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.
980. Artificial Intelligence-Supported Development of Health Guideline Questions.
作者: Bernardo Sousa-Pinto.;Rafael José Vieira.;Manuel Marques-Cruz.;Antonio Bognanni.;Sara Gil-Mata.;Slava Jankin.;Joana Amaro.;Liliane Pinheiro.;Marta Mota.;Mattia Giovannini.;Leticia de Las Vecillas.;Ana Margarida Pereira.;Justyna Lityńska.;Boleslaw Samolinski.;Jonathan Bernstein.;Mark Dykewicz.;Martin Hofmann-Apitius.;Marc Jacobs.;Nikolaos Papadopoulos.;Sian Williams.;Torsten Zuberbier.;João A Fonseca.;Ricardo Cruz-Correia.;Jean Bousquet.;Holger J Schünemann.
来源: Ann Intern Med. 2024年177卷11期1518-1529页
Guideline questions are typically proposed by experts.
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