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5765. Phenome-Wide Association Studies.
Genome-wide association studies (GWAS) have made clear that single-nucleotide variants (SNVs) that occur at multiple locations across the genome can be associated with a specific condition or trait, also known as a phenotype. Phenome-wide association studies (PheWAS) invert the idea of a GWAS by searching for phenotypes associated with specific SNVs across the range of thousands of human phenotypes, or the “phenome” (Figure). Analogous to GWAS, PheWAS have shown that specific genetic variations may be associated with multiple conditions and traits.
5777. Association Between Maternal Hormonal Contraception Use and Central Nervous System Tumors in Children.
作者: Marie Hargreave.;Lina S Mørch.;Jeanette F Winther.;Kjeld Schmiegelow.;Susanne K Kjaer.
来源: JAMA. 2022年327卷1期59-66页
The incidence of central nervous system (CNS) tumors in children appears to be increasing, yet few risk factors are established. There is limited information regarding whether maternal hormonal contraception use increases this risk.
5778. Effect of a Community-Based Medical Oncology Depression Screening Program on Behavioral Health Referrals Among Patients With Breast Cancer: A Randomized Clinical Trial.
作者: Erin E Hahn.;Corrine E Munoz-Plaza.;Dana Pounds.;Lindsay Joe Lyons.;Janet S Lee.;Ernest Shen.;Benjamin D Hong.;Shannon La Cava.;Farah M Brasfield.;Lara N Durna.;Karen W Kwan.;David B Beard.;Alexander Ferreira.;Aswini Padmanabhan.;Michael K Gould.
来源: JAMA. 2022年327卷1期41-49页
Implementation of guideline-recommended depression screening in medical oncology remains challenging. Evidence suggests that multicomponent care pathways with algorithm-based referral and management are effective, yet implementation of sustainable programs remains limited and implementation-science guided approaches are understudied.
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