541. Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial.
作者: Michael C Reade.;Denese C Marks.;Belinda D Howe.;Michael J Bailey.;Paul G Bannon.;Glenn M Eastwood.;Craig J French.;David J Gattas.;Alisa M Higgins.;Anthony D Holley.;Raymond T Hu.;David O Irving.;Lacey Johnson.;Shay P McGuinness.;Zoe K McQuilten.;Alistair G Royse.;Julian A Smith.;Laurence Weinberg.;Erica M Wood.; .; .
来源: JAMA. 2026年335卷7期600-608页
Liquid-stored platelets have a shelf-life of 5 to 7 days, limiting availability and resulting in wastage.
544. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial.
作者: Evangelos J Giamarellos-Bourboulis.;Antigone Kotsaki.;Ioanna Kotsamidi.;Aikaterini Efthymiou.;Vasiliki Koutsoukou.;Johannes Ehler.;Alexandra Paridou.;Frantzeska Frantzeskaki.;Marcella C A Müller.;Peter Pickkers.;Sylvain Meylan.;Ioannis Nikolopoulos.;Mihaela Lupse.;Alexandra Gavala.;Glykeria Vlachogianni.;Nicky Solomonidi.;Antonia Alevizou.;Eumorfia Kondili.;Eleni Antoniadou.;Maria Nakou.;Nikolaos Markou.;Erifili Hatziagelaki.;Athanassios Prekates.;Apostolos Komnos.;Lieke Bakkerus.;Marleen A Slim.;George N Dalekos.;Areti Karapanagiotou.;Sofia Ktena.;Gennaro De Pascale.;Vassileios Koulouras.;Christos Psarrakis.;Eleni Massa.;Konstantina Dakou.;Chrisoula Pazvanti.;Aikaterini Ioakeimidou.;Iraklis Tsangaris.;Nikolaos Antonakos.;Alexander P J Vlaar.;Souzana Anisoglou.;Thierry Calandra.;Vasilios Papaioannou.;Pavlos Myrianthefs.;Maria Patrani.;Ioannis Alamanos.;Massimo Antonelli.;Jos W M van der Meer.;Tom van der Poll.;W Joost Wiersinga.;Maria Ntaganou.;Eleni Gkeka.;Michael Bauer.;Eleni Mouloudi.;Mihai G Netea.; .
来源: JAMA. 2026年335卷9期775-786页
Sepsis is heterogeneous, and the optimal strategy for tailoring immunotherapy is uncertain.
550. Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger.
作者: Brett Burstein.;Thomas Waterfield.;Etimbuk Umana.;Jianling Xie.;Nathan Kuppermann.
来源: JAMA. 2026年335卷5期425-433页
Fever in the first month of life is often the only sign of life-threatening invasive bacterial infection, specifically bacteremia or bacterial meningitis. Most international guidelines recommend routine lumbar punctures for all febrile infants 28 days or younger to rule out bacterial meningitis. Clinical prediction rules may allow for select testing, but limited information exists on their performance to identify infants at low risk for invasive bacterial infections.
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