5162. Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes: A Randomized Clinical Trial.
作者: Gregory P Forlenza.;Jennifer McVean.;Roy W Beck.;Colleen Bauza.;Ryan Bailey.;Bruce Buckingham.;Linda A DiMeglio.;Jennifer L Sherr.;Mark Clements.;Anna Neyman.;Carmella Evans-Molina.;Emily K Sims.;Laurel H Messer.;Laya Ekhlaspour.;Ryan McDonough.;Michelle Van Name.;Diana Rojas.;Shannon Beasley.;Stephanie DuBose.;Craig Kollman.;Antoinette Moran.; .
来源: JAMA. 2023年329卷12期990-999页
In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death. Calcium channel blockers reduce these effects and may be beneficial to beta cell preservation in type 1 diabetes.
5164. Effect of Tight Glycemic Control on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes: A Randomized Clinical Trial.
作者: Jennifer McVean.;Gregory P Forlenza.;Roy W Beck.;Colleen Bauza.;Ryan Bailey.;Bruce Buckingham.;Linda A DiMeglio.;Jennifer L Sherr.;Mark Clements.;Anna Neyman.;Carmella Evans-Molina.;Emily K Sims.;Laurel H Messer.;Laya Ekhlaspour.;Ryan McDonough.;Michelle Van Name.;Diana Rojas.;Shannon Beasley.;Stephanie DuBose.;Craig Kollman.;Antoinette Moran.; .
来源: JAMA. 2023年329卷12期980-989页
Near normalization of glucose levels instituted immediately after diagnosis of type 1 diabetes has been postulated to preserve pancreatic beta cell function by reducing glucotoxicity. Previous studies have been hampered by an inability to achieve tight glycemic goals.
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