5056. Early vs Interval Postpartum Intrauterine Device Placement: A Randomized Clinical Trial.
作者: Sarah Averbach.;Gennifer Kully.;Erica Hinz.;Arnab Dey.;Holly Berkley.;Marisa Hildebrand.;Florin Vaida.;Sadia Haider.;Lisa G Hofler.
来源: JAMA. 2023年329卷11期910-917页
The early postpartum period, 2 to 4 weeks after birth, may be a convenient time for intrauterine device (IUD) placement; the placement could then coincide with early postpartum or well-baby visits.
5057. Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review.
Chronic lymphocytic leukemia (CLL), defined by a minimum of 5 × 109/L monoclonal B cells in the blood, affects more than 200 000 people and is associated with approximately 4410 deaths in the US annually. CLL is associated with an immunocompromised state and an increased rate of complications from infections.
5059. Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19.
作者: Ewan C Goligher.;Patrick R Lawler.;Thomas P Jensen.;Victor Talisa.;Lindsay R Berry.;Elizabeth Lorenzi.;Bryan J McVerry.;Chung-Chou Ho Chang.;Eric Leifer.;Charlotte Bradbury.;Jeffrey Berger.;Beverly J Hunt.;Lana A Castellucci.;Lucy Z Kornblith.;Anthony C Gordon.;Colin McArthur.;Steven Webb.;Judith Hochman.;Matthew D Neal.;Ryan Zarychanski.;Scott Berry.;Derek C Angus.; .
来源: JAMA. 2023年329卷13期1066-1077页
Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of treatment effect (HTE) across individuals. Better understanding of HTE could facilitate individualized clinical decision-making.
5060. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.
作者: Pierre Bouzat.;Jonathan Charbit.;Paer-Selim Abback.;Delphine Huet-Garrigue.;Nathalie Delhaye.;Marc Leone.;Guillaume Marcotte.;Jean-Stéphane David.;Albrice Levrat.;Karim Asehnoune.;Julien Pottecher.;Jacques Duranteau.;Elie Courvalin.;Anais Adolle.;Dimitri Sourd.;Jean-Luc Bosson.;Bruno Riou.;Tobias Gauss.;Jean-François Payen.; .
来源: JAMA. 2023年329卷16期1367-1375页
Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood product consumption.
|