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共有 4962 条符合本次的查询结果, 用时 5.878884 秒

4721. Our commitment to help accelerate progress against cancer.

作者: The Lancet.
来源: Lancet. 2022年399卷10327期769页

4722. Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial.

作者: Timothy Craig.;Markus Magerl.;Donald S Levy.;Avner Reshef.;William R Lumry.;Inmaculada Martinez-Saguer.;Joshua S Jacobs.;William H Yang.;Bruce Ritchie.;Emel Aygören-Pürsün.;Paul K Keith.;Paula Busse.;Henrike Feuersenger.;Dipti Pawaskar.;Iris Jacobs.;Ingo Pragst.;Mittie K Doyle.
来源: Lancet. 2022年399卷10328期945-955页
Hereditary angioedema is associated with dysregulation of the kallikrein-kinin system. Factor XII (FXII) is a key initiator of the kallikrein-kinin system, which produces bradykinin, a central mediator of angioedema. Garadacimab (CSL Behring) is a first-in-class, fully human, immunoglobulin G4 monoclonal antibody targeting activated FXII, intended to prevent attacks in patients with C1-esterase inhibitor-deficient hereditary angioedema (HAE-C1-INH). We aimed to investigate garadacimab as a treatment every 4 weeks for patients with HAE-C1-INH.

4723. Variation in the COVID-19 infection-fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis.

作者: .
来源: Lancet. 2022年399卷10334期1469-1488页
The infection-fatality ratio (IFR) is a metric that quantifies the likelihood of an individual dying once infected with a pathogen. Understanding the determinants of IFR variation for COVID-19, the disease caused by the SARS-CoV-2 virus, has direct implications for mitigation efforts with respect to clinical practice, non-pharmaceutical interventions, and the prioritisation of risk groups for targeted vaccine delivery. The IFR is also a crucial parameter in COVID-19 dynamic transmission models, providing a way to convert a population's mortality rate into an estimate of infections.

4724. Understanding of COVID-19 from infection-fatality ratio.

作者: Xiaoying Gu.;Bin Cao.
来源: Lancet. 2022年399卷10334期1442-1443页

4725. Prophylaxis with anti-activated factor XII for hereditary angioedema.

作者: Lauré M Fijen.;Marcel Levi.
来源: Lancet. 2022年399卷10328期889-890页

4726. Vaccine apartheid: global cooperation and equity.

作者: Simar Singh Bajaj.;Lwando Maki.;Fatima Cody Stanford.
来源: Lancet. 2022年399卷10334期1452-1453页

4727. 2022 Tyler Prize: Andy Haines.

作者: Talha Burki.
来源: Lancet. 2022年399卷10328期e11页

4728. Waning of COVID-19 vaccine effectiveness: individual and public health risk.

作者: Vanessa Piechotta.;Thomas Harder.
来源: Lancet. 2022年399卷10328期887-889页

4729. Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression.

作者: Daniel R Feikin.;Melissa M Higdon.;Laith J Abu-Raddad.;Nick Andrews.;Rafael Araos.;Yair Goldberg.;Michelle J Groome.;Amit Huppert.;Katherine L O'Brien.;Peter G Smith.;Annelies Wilder-Smith.;Scott Zeger.;Maria Deloria Knoll.;Minal K Patel.
来源: Lancet. 2022年399卷10328期924-944页
Knowing whether COVID-19 vaccine effectiveness wanes is crucial for informing vaccine policy, such as the need for and timing of booster doses. We aimed to systematically review the evidence for the duration of protection of COVID-19 vaccines against various clinical outcomes, and to assess changes in the rates of breakthrough infection caused by the delta variant with increasing time since vaccination.

4730. Decoupling of omicron variant infections and severe COVID-19.

作者: Shabir A Madhi.;Chikwe Ihekweazu.;Helen Rees.;Andrew J Pollard.
来源: Lancet. 2022年399卷10329期1047-1048页

4731. Sexual misconduct in medicine must end.

作者: Jessamy Bagenal.;Nancy Baxter.
来源: Lancet. 2022年399卷10329期1030-1032页

4732. COVID-19 booster doses in pregnancy and global vaccine equity.

作者: Erkan Kalafat.;Laura A Magee.;Peter von Dadelszen.;Paul Heath.;Asma Khalil.
来源: Lancet. 2022年399卷10328期907-908页

4733. The Lancet Breast Cancer Commission: tackling a global health, gender, and equity challenge.

作者: Charlotte Elizabeth Coles.;Benjamin O Anderson.;David Cameron.;Fatima Cardoso.;Richard Horton.;Felicia Marie Knaul.;Miriam Mutebi.;Naomi Lee.; .
来源: Lancet. 2022年399卷10330期1101-1103页

4734. The children of Afghanistan need urgent mental health support.

作者: Sheikh Shoib.;Mohammad Yasir Essar.;Sheikh Mohd Saleem.;Zahra Legris.;Miyuru Chandradasa.
来源: Lancet. 2022年399卷10329期1045-1046页

4735. Military attacks on health workers in Sudan.

作者: Majdi Osman.;Mohamed Nagy Alassam.
来源: Lancet. 2022年399卷10329期1045页

4736. The bleak future of Afghan women's health under the Taliban.

作者: Lamba Saboor.;Lida Ahmad.;Ayesha Ahmad.
来源: Lancet. 2022年399卷10328期893-894页

4738. Hearing but not understanding: word deafness from a brainstem lesion.

作者: Jacob M Pogson.;G Michael Halmagyi.
来源: Lancet. 2022年399卷10326期756页

4739. Steroid use in non-pneumococcal and non-Haemophilus bacterial meningitis - Authors' reply.

作者: Diederik van de Beek.;Matthijs C Brouwer.;Uwe Koedel.;Emma C Wall.
来源: Lancet. 2022年399卷10326期718页

4740. Steroid use in non-pneumococcal and non-Haemophilus bacterial meningitis.

作者: Dominic Heining.;Aiden J Plant.
来源: Lancet. 2022年399卷10326期717-718页
共有 4962 条符合本次的查询结果, 用时 5.878884 秒