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4681. Impact of Patient-Reported Outcome Measurement in Heart Failure Clinic on Clinician Health Status Assessment and Patient Experience: A Substudy of the PRO-HF Trial.
作者: Alexander T Sandhu.;Jimmy Zheng.;Neil M Kalwani.;Anshal Gupta.;Jamie Calma.;Megan Skye.;Roy Lan.;Brian Yu.;John A Spertus.;Paul A Heidenreich.
来源: Circ Heart Fail. 2023年16卷2期e010280页
Clinicians typically estimate heart failure health status using the New York Heart Association Class, which is often discordant with patient-reported health status. It is unknown whether collecting patient-reported health status improves the accuracy of clinician assessments.
4682. Social and Psychosocial Determinants of Racial and Ethnic Differences in Cardiovascular Health in the United States Population.
作者: Nilay S Shah.;Xiaoning Huang.;Lucia C Petito.;Michael P Bancks.;Hongyan Ning.;Natalie A Cameron.;Kiarri N Kershaw.;Namratha R Kandula.;Mercedes R Carnethon.;Donald M Lloyd-Jones.;Sadiya S Khan.
来源: Circulation. 2023年147卷3期190-200页
Social and psychosocial factors are associated with cardiovascular health (CVH). Our objective was to examine the contributions of individual-level social and psychosocial factors to racial and ethnic differences in population CVH in the NHANES (National Health and Nutrition Examination Surveys) 2011 to 2018, to inform strategies to mitigate CVH inequities.
4683. Transcatheter Mitral Paravalvular Leak Closure Using Arteriovenous Rail Across Aortic Bileaflet Mechanical Prosthesis: Multimodality Imaging Approach.
作者: Alessandro Beneduce.;Marco Bruno Ancona.;Filippo Russo.;Luca Angelo Ferri.;Barbara Bellini.;Ciro Vella.;Vittorio Romano.;Francesco Ancona.;Eustachio Agricola.;Matteo Montorfano.
来源: Circ Cardiovasc Imaging. 2023年16卷3期e014267页 4685. A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve.
作者: Marcos Siguero-Álvarez.;Alejandro Salguero-Jiménez.;Joaquim Grego-Bessa.;Jorge de la Barrera.;Donal MacGrogan.;Belén Prados.;Fernando Sánchez-Sáez.;Rebeca Piñeiro-Sabarís.;Natalia Felipe-Medina.;Carlos Torroja.;Manuel José Gómez.;María Sabater-Molina.;Rubén Escribá.;Ivonne Richaud-Patin.;Olalla Iglesias-García.;Mauro Sbroggio.;Sergio Callejas.;Declan P O'Regan.;Kathryn A McGurk.;Ana Dopazo.;Giovanna Giovinazzo.;Borja Ibañez.;Lorenzo Monserrat.;José María Pérez-Pomares.;Fátima Sánchez-Cabo.;Alberto M Pendas.;Angel Raya.;Juan R Gimeno-Blanes.;José Luis de la Pompa.
来源: Circulation. 2023年147卷1期47-65页
The complex genetics underlying human cardiac disease is evidenced by its heterogenous manifestation, multigenic basis, and sporadic occurrence. These features have hampered disease modeling and mechanistic understanding. Here, we show that 2 structural cardiac diseases, left ventricular noncompaction (LVNC) and bicuspid aortic valve, can be caused by a set of inherited heterozygous gene mutations affecting the NOTCH ligand regulator MIB1 (MINDBOMB1) and cosegregating genes.
4686. Intravascular Ultrasound and Multidetector Computed Tomography Imaging of Polymethylmethacrylate Cement Leakage Inducing Inferior Vena Cava Thrombosis.
作者: Rei-Yeuh Chang.;Tsung-Hsien Chen.;Chu-Jen Kuo.;Han-Lin Tsai.
来源: Circ Cardiovasc Imaging. 2023年16卷2期e014527页 4687. Enhancing Sweat Rate Using a Novel Device for the Treatment of Congestion in Heart Failure.
作者: Doron Aronson.;Yaacov Nitzan.;Sirouch Petcherski.;Evgeny Bravo.;Manhal Habib.;Daniel Burkhoff.;William T Abraham.
来源: Circ Heart Fail. 2023年16卷1期e009787页
Current treatment of fluid retention in heart failure relies primarily on diuretics. However, adequate decongestion is not achieved in many patients. We aimed to study the feasibility and short-term performance of a novel approach to remove fluids and sodium directly from the interstitial compartment by enhancing sweat rate.
4688. Noncanonical Form of ERAD Regulates Cardiac Hypertrophy.
作者: Erik A Blackwood.;Lauren F MacDonnell.;Donna J Thuerauf.;Alina S Bilal.;Victoria B Murray.;Kenneth C Bedi.;Kenneth B Margulies.;Christopher C Glembotski.
来源: Circulation. 2023年147卷1期66-82页
Cardiac hypertrophy increases demands on protein folding, which causes an accumulation of misfolded proteins in the endoplasmic reticulum (ER). These misfolded proteins can be removed by the adaptive retrotranslocation, polyubiquitylation, and a proteasome-mediated degradation process, ER-associated degradation (ERAD), which, as a biological process and rate, has not been studied in vivo. To investigate a role for ERAD in a pathophysiological model, we examined the function of the functional initiator of ERAD, valosin-containing protein-interacting membrane protein (VIMP), positing that VIMP would be adaptive in pathological cardiac hypertrophy in mice.
4689. Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models.
作者: Richard G Lee.;Anne Marie Mazzola.;Maurine C Braun.;Colin Platt.;Scott B Vafai.;Sekar Kathiresan.;Ellen Rohde.;Andrew M Bellinger.;Amit V Khera.
来源: Circulation. 2023年147卷3期242-253页
VERVE-101 is an investigational in vivo CRISPR base-editing medicine designed to alter a single DNA base in the PCSK9 gene, permanently turn off hepatic protein production, and thereby durably lower low-density lipoprotein cholesterol. We test the efficacy, durability, tolerability, and potential for germline editing of VERVE-101 in studies of nonhuman primates and a murine F1 progeny study.
4690. Adoption of Sacubitril/Valsartan Among Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The Get With The Guidelines-Heart Failure Registry.
作者: Jacob B Pierce.;Zhen Li.;Melissa A Greiner.;Steven J Lippmann.;N Chantelle Hardy.;Xian Shen.;Mark Stampehl.;Robert J Mentz.;Larry A Allen.;Pamela N Peterson.;Gregg C Fonarow.;Emily C O'Brien.;Stephen J Greene.
来源: Circ Heart Fail. 2023年16卷1期e010176页 4691. RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart Through Long Noncoding RNA-H19.
作者: Vagner Oliveira Carvalho Rigaud.;Robert C Hoy.;Justin Kurian.;Clare Zarka.;Michael Behanan.;Isabella Brosious.;Jennifer Pennise.;Tej Patel.;Tao Wang.;Jaslyn Johnson.;Lindsay M Kraus.;Sadia Mohsin.;Steven R Houser.;Mohsin Khan.
来源: Circulation. 2023年147卷4期324-337页
Developmental cardiac tissue holds remarkable capacity to regenerate after injury and consists of regenerative mononuclear diploid cardiomyocytes. On maturation, mononuclear diploid cardiomyocytes become binucleated or polyploid and exit the cell cycle. Cardiomyocyte metabolism undergoes a profound shift that coincides with cessation of regeneration in the postnatal heart. However, whether reprogramming metabolism promotes persistence of regenerative mononuclear diploid cardiomyocytes enhancing cardiac function and repair after injury is unknown. Here, we identify a novel role for RNA-binding protein LIN28a, a master regulator of cellular metabolism in cardiac repair after injury.
4692. In-Hospital Virtual Peer-to-Peer Consultation to Increase Guideline-Directed Medical Therapy for Heart Failure: A Pilot Randomized Trial.
作者: Vishal N Rao.;Anand Shah.;Jaime McDermott.;Stephanie G Barnes.;Evan M Murray.;Michelle D Kelsey.;Stephen J Greene.;Marat Fudim.;Adam D DeVore.;Chetan B Patel.;Michael A Blazing.;Cara O'Brien.;Robert J Mentz.
来源: Circ Heart Fail. 2023年16卷2期e010158页
Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) improves clinical outcomes and quality of life. Optimizing GDMT in the hospital is associated with greater long-term use in HFrEF. This study aimed to describe the efficacy of a multidisciplinary virtual HF intervention on GDMT optimization among patients with HFrEF admitted for any cause.
4693. Comparing New York Heart Association Class and Patient-Reported Outcomes Among Patients Hospitalized for Heart Failure.
作者: Michael F Cosiano.;Andrew Vista.;Jie-Lena Sun.;Brooke Alhanti.;Josephine Harrington.;Javed Butler.;Randall C Starling.;Robert J Mentz.;Stephen J Greene.
来源: Circ Heart Fail. 2023年16卷1期e010107页
Alignment between clinician-reported New York Heart Association (NYHA) class compared and patient-reported outcomes among patients hospitalized for heart failure is unclear.
4694. A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction.
作者: Peter H Brubaker.;Barbara J Nicklas.;Denise K Houston.;W Gregory Hundley.;Haiying Chen.;Anthony J A Molina.;W Mary Lyles.;Benjamin Nelson.;Bharathi Upadhya.;Russell Newland.;Dalane W Kitzman.
来源: Circ Heart Fail. 2023年16卷2期e010161页
We have shown that combined caloric restriction (CR) and aerobic exercise training (AT) improve peak exercise O2 consumption (VO2peak), and quality-of-life in older patients with obese heart failure with preserved ejection fraction. However, ≈35% of weight lost during CR+AT was skeletal muscle mass. We examined whether addition of resistance training (RT) to CR+AT would reduce skeletal muscle loss and further improve outcomes.
4695. Heterogeneity in the Association Between the Presence of Coronary Artery Calcium and Cardiovascular Events: A Machine-Learning Approach in the MESA Study.
作者: Kosuke Inoue.;Teresa E Seeman.;Tamara Horwich.;Matthew J Budoff.;Karol E Watson.
来源: Circulation. 2023年147卷2期132-141页
Coronary artery calcium (CAC) has been widely recognized as an important predictor of cardiovascular disease (CVD). Given the finite resources, it is important to identify individuals who would receive the most benefit from detecting positive CAC by screening. However, the evidence is limited as to whether the burden of positive CAC on CVD differs by multidimensional individual characteristics. We sought to investigate the heterogeneity in the association between positive CAC and incident CVD.
4696. Venovenous Bridge Connecting Systemic and Pulmonary Venous Circulation: An Antecedent of the Sinus Venosus Defect.
作者: Niraj Nirmal Pandey.;Aprateem Mukherjee.;Vineeta Ojha.;Sravan Nagulakonda.;Priya Jagia.;Sivasubramanian Ramakrishnan.
来源: Circ Cardiovasc Imaging. 2023年16卷2期e014614页 4697. Racial Inequities in Access to Ventricular Assist Device and Transplant Persist After Consideration for Preferences for Care: A Report From the REVIVAL Study.
作者: Thomas M Cascino.;Monica M Colvin.;David E Lanfear.;Blair Richards.;Shokoufeh Khalatbari.;Douglas L Mann.;Wendy C Taddei-Peters.;Neal Jeffries.;Daphne C Watkins.;Garrick C Stewart.;Keith D Aaronson.; .
来源: Circ Heart Fail. 2023年16卷1期e009745页
Racial disparities in access to advanced therapies for heart failure (HF) patients are well documented, although the reasons remain uncertain. We sought to determine the association of race on utilization of ventricular assist device (VAD) and transplant among patients with access to care at VAD centers and if patient preferences impact the effect.
4698. Unusual Case of High-Flow Left Heart Failure: Physiopathology, Multimodality Imaging, and Endovascular Management.
作者: Ralph Khoury.;Clairelyne Dupin.;Caroline Nguyen.;Marin Halut.;Pierre Mordant.;Antoine Khalil.
来源: Circ Cardiovasc Imaging. 2023年16卷2期e014219页 4699. Close Relationship Between Severe Pectus Excavatum and Low Voltage Area/Delayed Potentials at Right Ventricular Outflow Tract: Observations in Patient With Brugada Syndrome.
作者: Masaki Takahashi.;Ichitaro Abe.;Yumi Ishii.;Nozomi Kodama.;Kei Hirota.;Hidekazu Kondo.;Akira Fukui.;Tetsuji Shinohara.;Mikiko Nakagawa.;Naohiko Takahashi.
来源: Circ Cardiovasc Imaging. 2023年16卷2期e014536页 |