当前位置: 首页 >> 检索结果
4601. Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial.
作者: Kohei Nakachi.;Masafumi Ikeda.;Masaru Konishi.;Shogo Nomura.;Hiroshi Katayama.;Tomoko Kataoka.;Akiko Todaka.;Hiroaki Yanagimoto.;Soichiro Morinaga.;Shogo Kobayashi.;Kazuaki Shimada.;Yu Takahashi.;Toshio Nakagohri.;Kunihito Gotoh.;Ken Kamata.;Yasuhiro Shimizu.;Makoto Ueno.;Hiroshi Ishii.;Takuji Okusaka.;Junji Furuse.; .
来源: Lancet. 2023年401卷10372期195-203页
S-1 has shown promising efficacy with a mild toxicity profile in patients with advanced biliary tract cancer. The aim of this study was to evaluate whether adjuvant S-1 improved overall survival compared with observation for resected biliary tract cancer.
4615. Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study.
作者: Jose Villar.;Constanza P Soto Conti.;Robert B Gunier.;Shabina Ariff.;Rachel Craik.;Paolo I Cavoretto.;Stephen Rauch.;Serena Gandino.;Ricardo Nieto.;Adele Winsey.;Camilla Menis.;Gabriel B Rodriguez.;Valeria Savasi.;Niyazi Tug.;Sonia Deantoni.;Marta Fabre.;Begoña Martinez de Tejada.;Maria Jose Rodriguez-Sibaja.;Stefania Livio.;Raffaele Napolitano.;Nerea Maiz.;Helena Sobrero.;Ashley Peterson.;Philippe Deruelle.;Carolina Giudice.;Jagjit S Teji.;Roberto A Casale.;Laurent J Salomon.;Federico Prefumo.;Leila Cheikh Ismail.;Michael G Gravett.;Marynéa Vale.;Valeria Hernández.;Loïc Sentilhes.;Sarah R Easter.;Carola Capelli.;Emily Marler.;Daniela M Cáceres.;Guadalupe Albornoz Crespo.;Ernawati Ernawati.;Michal Lipschuetz.;Ken Takahashi.;Carmen Vecchiarelli.;Teresa Hubka.;Satoru Ikenoue.;Gabriela Tavchioska.;Babagana Bako.;Adejumoke I Ayede.;Brenda Eskenazi.;Jim G Thornton.;Zulfiqar A Bhutta.;Stephen H Kennedy.;Aris T Papageorghiou.; .
来源: Lancet. 2023年401卷10375期447-457页
In 2021, we showed an increased risk associated with COVID-19 in pregnancy. Since then, the SARS-CoV-2 virus has undergone genetic mutations. We aimed to examine the effects on maternal and perinatal outcomes of COVID-19 during pregnancy, and evaluate vaccine effectiveness, when omicron (B.1.1.529) was the variant of concern.
4616. 2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial.
作者: Elisabeth M L de Wijkerslooth.;Evert-Jan G Boerma.;Charles C van Rossem.;Joost van Rosmalen.;Coen I M Baeten.;Frédérique H Beverdam.;Johanna W A M Bosmans.;Esther C J Consten.;Jan Willem T Dekker.;Marloes Emous.;Anna A W van Geloven.;Anton F Gijsen.;Luc A Heijnen.;An P Jairam.;Damian C Melles.;Augustinus P T van der Ploeg.;Pascal Steenvoorde.;Boudewijn R Toorenvliet.;Maarten Vermaas.;Bas Wiering.;Bas P L Wijnhoven.;Anne Loes van den Boom.; .
来源: Lancet. 2023年401卷10374期366-376页
The appropriate duration of postoperative antibiotics for complex appendicitis is unclear. The increasing global threat of antimicrobial resistance warrants restrictive antibiotic use, which could also reduce side-effects, length of hospital stay, and costs.
4620. Stopping epidemics when and where they occur.
作者: Els Torreele.;Michel Kazatchkine.;Joanne Liu.;Mark Dybul.;Mauricio Cárdenas.;Sudhvir Singh.;Helena Legido Quigley.;Christine McNab.;Ellen Johnson Sirleaf.;Mariana Mazzucato.;Helen Clark.
来源: Lancet. 2023年401卷10374期324-328页 |