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4602. MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial.
作者: Karl Georg Haeusler.;Felizitas A Eichner.;Peter U Heuschmann.;Jochen B Fiebach.;Tobias Engelhorn.;Benjamin Blank.;David Callans.;Arif Elvan.;Massimo Grimaldi.;Jim Hansen.;Gerhard Hindricks.;Hussein R Al-Khalidi.;Lluis Mont.;Jens Cosedis Nielsen.;Jonathan P Piccini.;Ulrich Schotten.;Sakis Themistoclakis.;Johan Vijgen.;Luigi Di Biase.;Paulus Kirchhof.
来源: Circulation. 2022年145卷12期906-915页
We aimed to assess the prevalence of ischemic brain lesions detected by magnetic resonance imaging and their association with cognitive function 3 months after first-time ablation using continuous oral anticoagulation in patients with paroxysmal atrial fibrillation (AF).
4603. Association of Pulmonary Artery Pulsatility Index With Adverse Cardiovascular Events Across a Hospital-Based Sample.
作者: Emily K Zern.;Dongyu Wang.;Paula Rambarat.;Samuel Bernard.;Samantha M Paniagua.;Elizabeth E Liu.;Jenna McNeill.;Jessica K Wang.;Carl T Andrews.;Eugene V Pomerantsev.;Michael H Picard.;Jennifer E Ho.
来源: Circ Heart Fail. 2022年15卷2期e009085页
The pulmonary artery pulsatility index (PAPi), calculated from the ratio of the pulmonary artery pulse pressure to right atrial pressure, is a predictor of right ventricular failure after inferior myocardial infarction and left ventricular assist device implantation. Whether PAPi is associated with adverse outcomes across a heterogeneous population is unknown.
4604. Concurrently Low Coronary Flow Reserve and Low Index of Microvascular Resistance Are Associated With Elevated Resting Coronary Flow in Patients With Chest Pain and Nonobstructive Coronary Arteries.
作者: Massimo Nardone.;Mary McCarthy.;Chris I Ardern.;Lynne E Nield.;Olga Toleva.;Warren J Cantor.;Steven E S Miner.
来源: Circ Cardiovasc Interv. 2022年15卷3期e011323页
Coronary microvascular function can be distinctly quantified using the coronary flow reserve (CFR) and index of microvascular resistance (IMR). Patients with low CFR can present with low or high IMR, although the prevalence and clinical characteristics of these patient groups remain unclear.
4605. CELSR1 Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome.
作者: Jeanne L Theis.;Talha Niaz.;Rhianna S Sundsbak.;Zachary C Fogarty.;William R Bamlet.;Donald J Hagler.;Timothy M Olson.
来源: Circ Genom Precis Med. 2022年15卷2期e003523页
Whole-genome sequencing in families enables deciphering of congenital heart disease causes. A shared genetic basis for familial bicuspid aortic valve (BAV) and hypoplastic left heart syndrome (HLHS) was postulated.
4606. Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk.
作者: Stefan Coassin.;Kevin Chemello.;Ilya Khantalin.;Lukas Forer.;Patricia Döttelmayer.;Sebastian Schönherr.;Rebecca Grüneis.;Clément Chong-Hong-Fong.;Brice Nativel.;Stéphane Ramin-Mangata.;Antonio Gallo.;Mathias Roche.;Beatrix Muelegger.;Christian Gieger.;Annette Peters.;Johannes Zschocke.;Catherine Marimoutou.;Olivier Meilhac.;Claudia Lamina.;Florian Kronenberg.;Valentin Blanchard.;Gilles Lambert.
来源: Circ Genom Precis Med. 2022年15卷2期e003489页
Lp(a) (lipoprotein [a]) is a highly atherogenic lipoprotein strongly associated with coronary artery disease (CAD). Lp(a) concentrations are chiefly determined genetically. Investigation of large pedigrees with extreme Lp(a) using modern whole-genome approaches may unravel the genetic determinants underpinning this pathological phenotype.
4607. Ultra-Rapid Nanopore Whole Genome Genetic Diagnosis of Dilated Cardiomyopathy in an Adolescent With Cardiogenic Shock.
作者: John E Gorzynski.;Sneha D Goenka.;Kishwar Shafin.;Tanner D Jensen.;Dianna G Fisk.;Megan E Grove.;Elizabeth Spiteri.;Trevor Pesout.;Jean Monlong.;Jonathan A Bernstein.;Scott Ceresnak.;Pi-Chuan Chang.;Jeffrey W Christle.;Henry Chubb.;Kyla Dunn.;Daniel R Garalde.;Joseph Guillory.;Maura R Z Ruzhnikov.;Chris Wright.;Courtney J Wusthoff.;Katherine Xiong.;Seth A Hollander.;Gerald J Berry.;Miten Jain.;Fritz J Sedlazeck.;Andrew Carroll.;Benedict Paten.;Euan A Ashley.
来源: Circ Genom Precis Med. 2022年15卷2期e003591页 4608. Five-Year Outcomes After Fractional Flow Reserve-Based Deferral of Revascularization in Chronic Coronary Syndrome: Final Results From the J-CONFIRM Registry.
作者: Shoichi Kuramitsu.;Hitoshi Matsuo.;Tomohiro Shinozaki.;Kazunori Horie.;Hiroaki Takashima.;Hidenobu Terai.;Yuetsu Kikuta.;Takayuki Ishihara.;Tatsuya Saigusa.;Tomohiro Sakamoto.;Nobuhiro Suematsu.;Yasutsugu Shiono.;Taku Asano.;Kenichi Tsujita.;Katsuhiko Masamura.;Tatsuki Doijiri.;Fumitoshi Toyota.;Manabu Ogita.;Tairo Kurita.;Akiko Matsuo.;Ken Harada.;Kenji Yaginuma.;Shinjo Sonoda.;Hiroyoshi Yokoi.;Nobuhiro Tanaka.; .
来源: Circ Cardiovasc Interv. 2022年15卷2期e011387页
Little large-scale data is available about the long-term (beyond 3 years) clinical outcomes after fractional flow reserve (FFR)-based deferral of revascularization in clinical practice. We sought to assess the 5-year outcomes after deferral of revascularization based on FFR.
4611. Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial.
作者: Iain M MacIntyre.;Emma J Turtle.;Tariq E Farrah.;Catriona Graham.;James W Dear.;David J Webb.; .
来源: Circulation. 2022年145卷6期416-423页
Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or no effect on blood pressure (BP). Although observational studies suggest that acetaminophen may increase BP, clinical trials are lacking. We, therefore, studied the effects of regular acetaminophen dosing on BP in individuals with hypertension.
4613. One-Year Major Cardiovascular Events After Restrictive Versus Liberal Blood Transfusion Strategy in Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Trial.
作者: Jose R Gonzalez-Juanatey.;Gilles Lemesle.;Etienne Puymirat.;Gregory Ducrocq.;Marine Cachanado.;Joan Albert Arnaiz.;Manuel Martínez-Sellés.;Johanne Silvain.;Albert Ariza-Solé.;Emile Ferrari.;Gonzalo Calvo.;Nicolas Danchin.;Cristina Avendano-Solá.;Alexandra Rousseau.;Eric Vicaut.;Teba Gonzalez-Ferrero.;Philippe Gabriel Steg.;Tabassome Simon.; .
来源: Circulation. 2022年145卷6期486-488页 4615. Causative Variants for Inherited Cardiac Conditions in a Southeast Asian Population Cohort.
作者: Swati Tomar.;David C Klinzing.;Ching Kit Chen.;Louis Hanqiang Gan.;Tia Moscarello.;Chloe Reuter.;Euan A Ashley.;Roger Foo.
来源: Circ Genom Precis Med. 2022年15卷2期e003536页
Variable penetrance and late-onset phenotypes are key challenges for classifying causal as well as incidental findings in inherited cardiac conditions. Allele frequencies of variants in ancestry-specific populations, along with clinical variant analysis and interpretation, are critical to determine their true significance.
4616. Common Polymorphism That Protects From Cardiovascular Disease Increases Fibronectin Processing and Secretion.
作者: Sébastien Soubeyrand.;Paulina Lau.;Majid Nikpay.;Anh-Thu Dang.;Ruth McPherson.
来源: Circ Genom Precis Med. 2022年15卷2期e003428页
Fibronectin (FN1) is an essential regulator of homodynamic processes and tissue remodeling that have been proposed to contribute to atherosclerosis. Moreover, recent large-scale genome-wide association studies (GWAS) have linked common genetic variants within the FN1 gene to coronary artery disease risk.
4617. How Communicating Polygenic and Clinical Risk for Atherosclerotic Cardiovascular Disease Impacts Health Behavior: an Observational Follow-up Study.
作者: Elisabeth Widén.;Nella Junna.;Sanni Ruotsalainen.;Ida Surakka.;Nina Mars.;Pietari Ripatti.;Juulia J Partanen.;Johanna Aro.;Pekka Mustonen.;Tiinamaija Tuomi.;Aarno Palotie.;Veikko Salomaa.;Jaakko Kaprio.;Jukka Partanen.;Kristina Hotakainen.;Pasi Pöllänen.;Samuli Ripatti.
来源: Circ Genom Precis Med. 2022年15卷2期e003459页
Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear.
4618. Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity.
作者: Sarah U Morton.;Alexandre C Pereira.;Daniel Quiat.;Felix Richter.;Alexander Kitaygorodsky.;Jacob Hagen.;Daniel Bernstein.;Martina Brueckner.;Elizabeth Goldmuntz.;Richard W Kim.;Richard P Lifton.;George A Porter.;Martin Tristani-Firouzi.;Wendy K Chung.;Amy Roberts.;Bruce D Gelb.;Yufeng Shen.;Jane W Newburger.;J G Seidman.;Christine E Seidman.
来源: Circ Genom Precis Med. 2022年15卷2期e003500页
Congenital heart disease (CHD) is the most common anomaly at birth, with a prevalence of ≈1%. While infants born to mothers with diabetes or obesity have a 2- to 3-fold increased incidence of CHD, the cause of the increase is unknown. Damaging de novo variants (DNV) in coding regions are more common among patients with CHD, but genome-wide rates of coding and noncoding DNVs associated with these prenatal exposures have not been studied in patients with CHD.
4619. Monomorphic and Polymorphic Ventricular Arrhythmias in Heterozygous Calsequestrin-2 Mutation Carriers.
作者: Juan Jiménez-Jáimez.;Mercedes Cabrera Ramos.;Francisco Bermúdez-Jiménez.;José Manuel García Pinilla.;Ainhoa Robles Mezcua.;Rosa Macías Ruiz.;Miguel Álvarez.;Luis Tercedor.
来源: Circ Genom Precis Med. 2022年15卷2期e003518页 4620. End Stage Mitochondrial Cardiomyopathy and Heart Transplantation Due to Biallelic Pathogenic C1QBP Variants.
作者: Nicholas S Wilcox.;Stuart B Prenner.;Marisa Cevasco.;Courtney Condit.;Amy Goldstein.;James T Peterson.;Isabella Tondi Resta.;Matthew Palmer.;Priti Lal.;Anjali Tiku Owens.;Janice Pieretti.;Theodore G Drivas.;Nosheen Reza.
来源: Circ Genom Precis Med. 2022年15卷2期e003559页 |