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4564. Vedolizumab for the Treatment of Chronic Pouchitis.
作者: Simon Travis.;Mark S Silverberg.;Silvio Danese.;Paolo Gionchetti.;Mark Löwenberg.;Vipul Jairath.;Brian G Feagan.;Brian Bressler.;Marc Ferrante.;Ailsa Hart.;Dirk Lindner.;Armella Escher.;Stephen Jones.;Bo Shen.; .
来源: N Engl J Med. 2023年388卷13期1191-1200页
Approximately half the patients with ulcerative colitis who undergo restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) will subsequently have pouchitis, and among those patients, one fifth will have chronic pouchitis.
4565. Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer.
作者: Yoshiaki Usui.;Yukari Taniyama.;Mikiko Endo.;Yuriko N Koyanagi.;Yumiko Kasugai.;Isao Oze.;Hidemi Ito.;Issei Imoto.;Tsutomu Tanaka.;Masahiro Tajika.;Yasumasa Niwa.;Yusuke Iwasaki.;Tomomi Aoi.;Nozomi Hakozaki.;Sadaaki Takata.;Kunihiko Suzuki.;Chikashi Terao.;Masanori Hatakeyama.;Makoto Hirata.;Kokichi Sugano.;Teruhiko Yoshida.;Yoichiro Kamatani.;Hidewaki Nakagawa.;Koichi Matsuda.;Yoshinori Murakami.;Amanda B Spurdle.;Keitaro Matsuo.;Yukihide Momozawa.
来源: N Engl J Med. 2023年388卷13期1181-1190页
Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. pylori infection, on the risk of gastric cancer has not been widely evaluated.
4566. Transcatheter Arterialization of Deep Veins in Chronic Limb-Threatening Ischemia.
作者: Mehdi H Shishehbor.;Richard J Powell.;Miguel F Montero-Baker.;Anahita Dua.;Jorge L Martínez-Trabal.;Matthew C Bunte.;Arthur C Lee.;Andrew S Mugglin.;Joseph L Mills.;Alik Farber.;Daniel G Clair.; .
来源: N Engl J Med. 2023年388卷13期1171-1180页
Approximately 20% of patients with chronic limb-threatening ischemia have no revascularization options, leading to above-ankle amputation. Transcatheter arterialization of the deep veins is a percutaneous approach that creates an artery-to-vein connection for delivery of oxygenated blood by means of the venous system to the ischemic foot to prevent amputation.
4570. Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer.
作者: Mansoor R Mirza.;Dana M Chase.;Brian M Slomovitz.;René dePont Christensen.;Zoltán Novák.;Destin Black.;Lucy Gilbert.;Sudarshan Sharma.;Giorgio Valabrega.;Lisa M Landrum.;Lars C Hanker.;Ashley Stuckey.;Ingrid Boere.;Michael A Gold.;Annika Auranen.;Bhavana Pothuri.;David Cibula.;Carolyn McCourt.;Francesco Raspagliesi.;Mark S Shahin.;Sarah E Gill.;Bradley J Monk.;Joseph Buscema.;Thomas J Herzog.;Larry J Copeland.;Min Tian.;Zangdong He.;Shadi Stevens.;Eleftherios Zografos.;Robert L Coleman.;Matthew A Powell.; .
来源: N Engl J Med. 2023年388卷23期2145-2158页
Dostarlimab is an immune-checkpoint inhibitor that targets the programmed cell death 1 receptor. The combination of chemotherapy and immunotherapy may have synergistic effects in the treatment of endometrial cancer.
4571. Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer.
作者: Ramez N Eskander.;Michael W Sill.;Lindsey Beffa.;Richard G Moore.;Joanie M Hope.;Fernanda B Musa.;Robert Mannel.;Mark S Shahin.;Guilherme H Cantuaria.;Eugenia Girda.;Cara Mathews.;Juraj Kavecansky.;Charles A Leath.;Lilian T Gien.;Emily M Hinchcliff.;Shashikant B Lele.;Lisa M Landrum.;Floor Backes.;Roisin E O'Cearbhaill.;Tareq Al Baghdadi.;Emily K Hill.;Premal H Thaker.;Veena S John.;Stephen Welch.;Amanda N Fader.;Matthew A Powell.;Carol Aghajanian.
来源: N Engl J Med. 2023年388卷23期2159-2170页
Standard first-line chemotherapy for endometrial cancer is paclitaxel plus carboplatin. The benefit of adding pembrolizumab to chemotherapy remains unclear.
4575. Air Pollution and Mortality at the Intersection of Race and Social Class.
作者: Kevin P Josey.;Scott W Delaney.;Xiao Wu.;Rachel C Nethery.;Priyanka DeSouza.;Danielle Braun.;Francesca Dominici.
来源: N Engl J Med. 2023年388卷15期1396-1404页
Black Americans are exposed to higher annual levels of air pollution containing fine particulate matter (particles with an aerodynamic diameter of ≤2.5 μm [PM2.5]) than White Americans and may be more susceptible to its health effects. Low-income Americans may also be more susceptible to PM2.5 pollution than high-income Americans. Because information is lacking on exposure-response curves for PM2.5 exposure and mortality among marginalized subpopulations categorized according to both race and socioeconomic position, the Environmental Protection Agency lacks important evidence to inform its regulatory rulemaking for PM2.5 standards.
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